Home>>2023 07 issue list
[601£­606] Application of BRAF mutations and targeted therapy in pediatric brain gliomas: successes and challenges
[Chen Zhihua1, Ji Xinting2, Gu Shuo1]
DOI:10.3760/cma.j.cn101785-202201049-001
[Absract] Objective Glioma is the most common brain tumor in children and adolescents.Conventional treatments have failed to prolong its progression-free survival.For some refractory, recurrent and unresectable gliomas, 5-year survival rate was merely 10%.Studies have demonstrated that some gliomas harbor mutations in B-type rapidly accelerated fibrosarcoma (BRAF) gene, providing an opportunity for BRAF-targeted therapy and creating a research hotspot in pediatric gliomas.Several international m... [MORE...]
[PDF:4913KB](125)
[607£­610] Arrival of the era of pan-tumor targeted drugs for children represented by TRK inhibitors
[Wu Yeming]
DOI:10.3760/cma.j.cn101785-202303020-002
[Absract] Objective With a rapid development of precision medicine, immunotherapy and molecular targeted drug dosing for advanced malignant solid tumors have been applied in children.Among them, the effectiveness and safety of TRK inhibitors larotrectinib and entrectinib in children with advanced malignant solid tumors with positive expressions of various NTRK fusion genes marks the arrival of the era of pan-tumor targeted drugs for children.This review focused upon the mechanisms and clinical r... [MORE...]
[PDF:2734KB](142)
[611£­618] Recent advances of targeted therapy for pediatric solid tumors
[Wang Shunying, Dong Kuiran]
DOI:10.3760/cma.j.cn101785-202304074-003
[Absract] Objective In recent years, targeted therapy has been applied extensively for pediatric solid tumors and some revolutionary advances have brought great hopes to children with unresectable, relapsed and refractory tumors. This review summarized the performance of targeted therapy for pediatric solid tumors.based on clinical trials in the past 5 years. [MORE...]
[PDF:5861KB](148)
[619£­624] Research advances of targeted therapy for neuroblastoma in children
[Long Junshan, Zhang Jing, Su Xiaoxia, Dong Qi]
DOI:10.3760/cma.j.cn101785-202303039-004
[Absract] Objective Neuroblastoma (NB) is a malignant solid tumor typically originating from sympathetic nervous system cells in children.Although traditional interventions of chemotherapy, surgery and radiotherapy may arrest the progression of NB, they often fail to obtain a complete cure.Recently targeted therapy has emerged as a novel therapeutic option for NB.Drugs or other means are employed for selectively acting upon certain molecules in tumor cells, thus inhibiting their growth and metas... [MORE...]
[PDF:4273KB](170)
[625£­629] Challenges and strategies in the diagnosis and treatment of neuroblastoma in adolescents and adults: one case report with a literature review
[Zhang Xin1, Jin Qianya2, Yuan Xiaojun1]
DOI:10.3760/cma.j.cn101785-202306028-005
[Absract] Objective Objective To explore the clinical characteristics, diagnosis, treatment and prognosis of neuroblastoma (NB) in adolescents and adults.Methods Retrospective review was conducted for a 24-year-old NB patient initially misdiagnosed as chromaffin cell tumor treated and followed-up at Xinhua Hospital.Diagnostic process, anti-disialoganglioside (GD2) monoclonal antibody immunotherapy and targeted treatment of anaplastic lymphoma kinase (ALK) inhibitor lorlatinib w... [MORE...]
[PDF:3312KB](134)
[630£­634] Preliminary study of analgesic during infusion of GD2 monoclonal antibody naxitamab in children
[Li Yan1, Zhang Congzhi1, Yin Shunhua1, Feng Yumeng1, Dong Qi2, Gu Shuo3, Zhuang Peijun4]
DOI:10.3760/cma.j.cn101785-202303043-006
[Absract] Objective Objective To explore the analgesic regimen of children during an infusion of GD2 monoclonal antibody naxitamab.Methods For this retrospective study, 167 naxitamab infusions were administered in 32 children with refractory neuroblastoma from August 2021 to February 2023 at Bo¡¯ao Branch of Hainan Women & Children¡¯s Medical Center.summarized the characteristics, location, duration and adverse reactions of pain caused by infusion.For relieving pain during in... [MORE...]
[PDF:3442KB](119)
[635£­641] Analysis of risk factors and causes of early recurrence of children with upper urinary tract calculi
[Zhong Qingtao, Zhang Deying, Wang Xuan, Zhang Li, He Xin, Liu Xing, He Dawei, Lin Tao, Li Xuliang, Wei Guanghui]
DOI:10.3760/cma.j.cn101785-202211008-007
[Absract] Objective Objective To explore the risk factors of upper urinary tract calculi (UUTC) and identify the causes of early recurrence in children.Methods For this case-control study, clinical data were retrospectively reviewed for 129 UUTC children at Children¡¯s Hospital of Chongqing Medical University from January 2017 to April 2021.They were assigned into two groups of UUTC (case, n=129) and non-UUTC (control, n=130).Social demographics, family history of ... [MORE...]
[PDF:3866KB](154)
[642£­648] Deep learning based intelligent auscultation of heart sounds in neonates with congenital heart disease
[Zhang Huiqiong1, Jia Weijie2, Yu Kai3, Xu Weize3]
DOI:10.3760/cma.j.cn101785-202207056-008
[Absract] Objective Objective To examine the heart sound signals of four common congenital heart diseases of ventricular septal defect, atrial septal defect, patent ductus arteriosus and patent foramen with associated pulmonary hypertension and propose a deep learning-based intelligent auscultation algorithm for automatic classification of heart sound signals.Methods The algorithm in this study was based upon digital signal processing technology of converting one-dimensional te... [MORE...]
[PDF:5203KB](116)
[649£­654] Clinical study on interhospital transport of pediatric patients with critical surgical injuries
[Yuan Yuanhong1, Zhang Hui2, Xiao Zhenghui1, Lu Xiulan1, Xu Zhiyue1, Zhang Xinping1, Kang Xiayan1, Zhao Xiaoping1, Zhu Lifeng1]
DOI:10.3760/cma.j.cn101785-202303068-009
[Absract] Objective Objective To review the clinical data of critical pediatric surgical trauma patients transported from hospital to hospital and provide suggestions for safe and effective transport.Methods Clinical data were retrospectively reviewed for 232 critically injured children actively transported between hospitals from January 2015 to January 2022 analyzed.According to whether or not pediatric trauma score (PTS) was ¡Ý 8, they were assigned into two groups of non-seri... [MORE...]
[PDF:3964KB](141)
[655£­659] Application of three-dimensional visualization technology for pediatric solid tumors
[Liao Wenge, Zhu Junjie, Zhang Haodong, Huang Hong, Wang Zhigang, Peng Qiang]
DOI:10.3760/cma.j.cn101785-202112034-010
[Absract] Objective Objective To explore the application value of preoperative three-dimensional visualization technology for pediatric solid tumors.Methods Retrospective analysis was performed for 23 children with solid tumors from January 2019 to December 2021.According to whether or not three-dimensional visualization was applied preoperatively, they were divided into two groups of study (n=11) and control (n=12).The research team performed three-dimensional vi... [MORE...]
[PDF:3521KB](117)
[660£­665] A comparative efficacy study of robot-assisted laparoscopy versus conventional laparoscopy for pelvic ureteral junction obstruction in children
[Liu Qi1, Xing Xinrang2, Zeng Xiaoxu1, Liu Xiaodong1, Luo Jiaqi2, Feng Qili2, Gao Yan2, Su Zeli2]
DOI:10.3760/cma.j.cn101785-202211037-011
[Absract] Objective Objective To explore the efficacy of robot-assisted laparoscopy versus conventional laparoscopy for ureteropelvic junction obsruction (UPJO) in children.Methods Retrospective review was conducted for clinical data of 63 UPJO children from January 2021 to May 2022.Robot-assisted laparoscopic pyeloplasty (RALP, n=31) and conventional laparoscopic pyeloplasty (RALP, n=32) were performed.General profiles such as age, gender, weight and affected sid... [MORE...]
[PDF:4174KB](154)
[666£­670] Clinical analysis of da Vinci robotic surgical system repair of paraesophageal hiatus hernia in children
[Gao Yue, Tan Zheng, Yu Jiangen, Liang Liang, Huang Ting, Zhang Jian]
DOI:10.3760/cma.j.cn101785-202106074-012
[Absract] Objective Objective To explore the efficacy and safety of da Vinci robotic surgical system (DVSS) for paraesophageal hiatus hernia in children.Methods From June 2020 to December 2020, 5 children of paraesophageal hiatus hernia was definitely diagnosed by upper gastrointestinal contrast radiography.They underwent DVSS.There were 3 boys and 2 girls with a mean age of (15.4¡À9.6) (5-28) months.Clinical types were ¢ñ (n=1), ¢ó (n=3) and ¢ô (n=1).Result... [MORE...]
[PDF:3726KB](122)
[671£­679] Meta-analysis of risk factors associated with recurrence of thyroid carcinoma in children and adolescents
[Ma Xin1, Zhou Kai1, Liang Yinbo1, Zhao Ge2]
DOI:10.3760/cma.j.cn101785-202211043-013
[Absract] Objective Objective To explore the risk factors of postoperative recurrence of thyroid carcinoma in children and adolescents (caTC) to identify the high-risk population of postoperative recurrence of caTC early.Methods According to the evidence-based medicine methodology, PubMed, Web of Science, China Wanfang and Chinese Biomedical Literature Database were searched for the risk factors of postoperative recurrence of caTC published since May 2022.According to the inclu... [MORE...]
[PDF:7501KB](105)
[680£­685] Xingnaojing injection suppressed neuronal pyrosis after oxygen-glucose deprivation/reperfusion injury through activating Nrf2/NLRP3/GSDMD signaling pathway
[Wen Haitao1, Chen Xiaoyan1, An Zheni2, Wu Shuihua1]
DOI:10.3760/cma.j.cn101785-202107045-014
[Absract] Objective Objective To explore the protective mechanism of refreshing static injection for injury of oxygen and glucose deprivation/reoxygenation (OGD/R) induced by SH SY5Y cells.Methods SH-SY5Y cells were pretreated with Xingnaojing Injection at different concentrations to determine its dosing concentration.SH-SY5Y cells were randomized into four groups of control, OGD/R, Xingnaojing Injection + OGD/R (10 ¦ÌL/mL Xingnaojing Injection) and Xingnaojing Injection+OGD/R +... [MORE...]
[PDF:5643KB](113)
[686£­688] Diagnosis and treatment of ectopic ureter of complete duplex kidneys without ureteral dilation in children: one case report
[Zhou Lijun, Xie Hua, Chen Fang]
DOI:10.3760/cma.j.cn101785-202204065-015
[PDF:2638KB](111)
[689£­693] Research advances on etiology and treatment of pediatric osteoporosis
[Wang Daoxi, Li Lang, Jiang Jun, Tang Xueyang, Liu Lijun]
DOI:10.3760/cma.j.cn101785-202303050-016
[Absract] Objective Affecting the skeletal development of children and adolescents, pediatric osteoporosis is one of the common causes leading to severe morbidity and reduced quality-of-life in children.Osteoporosis has a complex etiology and it may be divided into secondary and primary types.Secondary osteoporosis is more common with causes including long-term use of glucocorticoids, malignancies, cerebral palsy, muscular dystrophy and systemic lupus erythematosus.Primary osteoporosis is mostly... [MORE...]
[PDF:4227KB](138)
[694£­697] Research advances of tarsal coalition in adolescents
[Wu Ji, Li Xiongtao, Xia Jingdong, Zhang Ping, Shen Xiantao]
DOI:10.3760/cma.j.cn101785-202203058-017
[Absract] Objective Tarsal coalition (TC) is a developmental malformation occurring frequently in adolescents. There are few domestic reports on TC. However, the actual incidence rate is greatly underestimated. This review provided a comprehensive overview of the current literature pertaining to the etiology, epidemiology, pathology, clinical manifestations, radiological features, classifications and therapeutic advancements of TC. It was intended to enhance the understanding of pediatric orthop... [MORE...]
[PDF:3211KB](116)
[698£­700] Research advances in spinal fusion for adolescent idiopathic scoliosis
[Zhao Jun, Wang Peixin, Wang Xingsheng, Xu Shihong, Jiang Zhaoyang, Wang Xiaoqiang, Yang Hongjuan]
DOI:10.3760/cma.j.cn101785-202209052-018
[Absract] Objective As a common spinal deformity, adolescent idiopathic scoliosis (AIS) is frequently characterized by scoliosis plus spinal migration and vertebral rotation.Spinal fusion is a primary treatment for AIS patients with scoliosis angle greater than 45 degrees.It helps to correct the deformity, prevent scoliosis progression and maintain spinal balance.This review summarized the latest researches on the treatment of AIS with spinal fusion. [MORE...]
[PDF:2432KB](101)