Wen Haitao,Chen Xiaoyan,An Zheni,et al.Xingnaojing injection suppressed neuronal pyrosis after oxygen-glucose deprivation/reperfusion injury through activating Nrf2/NLRP3/GSDMD signaling pathway[J].Journal of Clinical Pediatric Surgery,,22():680-685.[doi:10.3760/cma.j.cn101785-202107045-014]
Click Copy

Xingnaojing injection suppressed neuronal pyrosis after oxygen-glucose deprivation/reperfusion injury through activating Nrf2/NLRP3/GSDMD signaling pathway

References:

[1] Zhao J, Piao XY, Wu Y, et al.Cepharanthine attenuates cerebral ischemia/reperfusion injury by reducing NLRP3 inflammasome-induced inflammation and oxidative stress via inhibiting 12/15-LOX signaling[J].Biomed Pharmacother, 2020, 127:110151.DOI:10.1016/j.biopha.2020.110151.
[2] Wei YY, Lan BD, Zheng T, et al.GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis[J].Nat Commun, 2023, 14(1):929.DOI:10.1038/s41467-023-36614-w.
[3] 吴京霓, 刘瑞敏, 许丹妮, 等.基于GC-MS技术及网络药理学探讨醒脑静注射液入脑成分抗脑缺血损伤的作用机制[J].中草药, 2021, 52(3):808-820.DOI:10.7501/j.issn.0253-2670.2021.03.024. Wu JN, Liu RM, Xu DN, et al.Anti-cerebral ischemia mechanisms of brain absorption components of Xingnaojing Injection based upon GC-MS and network pharmacology[J].Chin Tradit Herb Drugs, 2021, 52(3):808-820.DOI:10.7501/j.issn.0253-2670.2021.03.024.
[4] Zhou ZR, Zhao YH, Sun R, et al.Effects of Xingnaojing on serum high-sensitivity c-reactive protein and neuron-specific enolase in patients with acute cerebral hemorrhage:a protocol of systematic review and meta-analysis[J].Medicine (Baltimore), 2020, 99(45):e21379.DOI:10.1097/MD.0000000000021379.
[5] 王振凤, 田克姚, 刘南海.醒脑静注射液对MCAO大鼠神经功能、神经细胞炎症及氧化应激损伤的影响[J].中国现代医生, 2020, 58(36):36-39. Wang ZF, Tian KY, Liu NH.Effects of Xingnaojing Injection on nerve function, nerve cell inflammation and oxidative stress injury in MCAO rats[J].China Mod Dr, 2020, 58(36):36-39.
[6] 卢志刚, 黄家彬, 刘芸, 等.醒脑静注射液对急性脑梗死Keap1-Nrf2/ARE氧化应激通路的影响[J].广东医学, 2016, 37(20):3127-3129.DOI:10.3969/j.issn.1001-9448.2016.20.043. Lu ZG, Huang JB, Liu Y, et al.Effect of Xingnaojing Injection on the Keap1-Nrf2/ARE oxidative stress pathway in acute cerebral infarction[J].Guangdong Med J, 2016, 37(20):3127-3129.DOI:10.3969/j.issn.1001-9448.2016.20.043.
[7] 王文杰, 路娇娇, 马凯丰, 等.刺五加提取物对人神经细胞SH-SY5Y氧糖剥夺再灌注损伤的保护作用研究[J].世界科学技术-中医药现代化, 2022, 24(5):1772-1780.DOI:10.11842/wst.20211115008. Wang WJ, Lu JJ, Ma KF, et al.Protective effect of Acanthopanax senticosus extract on SH-SY5Y cells after oxygen and glucose deprivation reperfusion injury[J].Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology, 2022, 24(5):1772-1780.DOI:10.11842/wst.20211115008.
[8] Shi M, Chen J, Liu TX, et al.Protective effects of remimazolam on cerebral ischemia/reperfusion injury in rats by inhibiting of NLRP3 inflammasome-dependent pyroptosis[J].Drug Des Devel Ther, 2022, 16:413-423.DOI:10.2147/DDDT.S344240.
[9] Yang KL, Bao TT, Zeng JS, et al.Research progress on pyroptosis-mediated immune-inflammatory response in ischemic stroke and the role of natural plant components as regulator of pyroptosis:a review[J].Biomed Pharmacother, 2023, 157:113999.DOI:10.1016/j.biopha.2022.113999.
[10] de Sá KSG, Amaral LA, Rodrigues TS, et al.Gasdermin-D activation promotes NLRP3 activation and host resistance to Leishmania infection[J].Nat Commun, 2023, 14(1):1049.DOI:10.1038/s41467-023-36626-6.
[11] Yanpiset P, Maneechote C, Sriwichaiin S, et al.Gasdermin D-mediated pyroptosis in myocardial ischemia and reperfusion injury:cumulative evidence for future cardioprotective strategies[J].Acta Pharm Sin B, 2023, 13(1):29-53.DOI:10.1016/j.apsb.2022.08.007.
[12] Sun Y, Yang X, Xu LJ, et al.The role of Nrf2 in relieving cerebral ischemia-reperfusion injury[J].Curr Neuropharmacol, 2023, 21(6):1405-1420.DOI:10.2174/1570159X21666221129100308.
[13] Liao S, Wu JN, Liu RM, et al.A novel compound DBZ ameliorates neuroinflammation in LPS-stimulated microglia and ischemic stroke rats:role of Akt(Ser473)/GSK3β(Ser9)-mediated Nrf2 activation[J].Redox Biol, 2020, 36:101644.DOI:10.1016/j.redox.2020.101644.
[14] Xiao L, Dai ZW, Tang WJ, et al.Astragaloside IV alleviates cerebral ischemia-reperfusion injury through NLRP3 inflammasome-mediated pyroptosis inhibition via activating Nrf2[J].Oxid Med Cell Longev, 2021, 2021:9925561.DOI:10.1155/2021/9925561.

Memo

收稿日期:2021-07-23。
基金项目:湖南省中医药科研计划项目(2020108);湖南省卫生健康委课题(202104040560)
通讯作者:吴水华,Email:292454021@qq.com

Last Update: 1900-01-01