Home>>2019 03 issue list
[161£­166] The occurrence of initial process of 46,XY sex abnormal development and the corresponding management suggestions
[Tang Daxing]
DOI:10.3969/j.issn.1671-6353.2019.03.001
[Absract] Objective Based on the relevant literature reports in recent years,this paper reviews the basic process of 46,XY sex development in embryonic period,and analyzes and expounds the abnormal clinical symptoms of several important key points,and puts forward some corresponding treatment opinions.In addition,several unexpected issues involving sex abnormal development were described in the course of common surgical procedures in pediatric surgery and the corresponding suggestions for manage... [MORE...]
[PDF:870KB](895)
[167£­171] Gonadal management in 46,XY disorders of sexual development
[Yang Yi, Yin Xiaoming]
DOI:10.3969/j.issn.1671-6353.2019.03.002
[Absract] Objective Disorders of sex development (DSD) are a generic definition including any problem noted at birth where the genitalia are atypical in relation to chromosomes or gonads.According to the DSD classification of Chicago Conference,46,XY DSD is the most complex disorder of sexual development.Until now,optimal protocol has remained controversial in the gonad management of 46,XY DSD.Based upon a literature review and personal clinical experiences,gonadal management in 46,XY DSD was ad... [MORE...]
[PDF:763KB](558)
[172£­177] Evaluation and Treatment of 46,XY Disorders of Sex Development
[Gong Chunxiu, Li Lele]
DOI:10.3969/j.issn.1671-6353.2019.03.003
[Absract] Objective 46,XY disorders of sex development (DSD) refer to a wide range of conditions with diverse features and pathophysiology. Affected patients present with 46,XY karyotype,but their gonad and phenotypic gender are not inconsistent with the genetic gender. Its pathogenesis is complex,and the management is difficult. Any factor that affects the differentiation of testis,the synthesis of testosterone or the function of testosterone may lead to the occurrence of 46,XY DSD. A comprehen... [MORE...]
[PDF:1640KB](691)
[178£­183] Progression in evaluation methods and value of psychosexual development of disorder of sex development
[Tian Hongjuan1, Tang Daxing1, Yang Rongwang2]
DOI:10.3969/j.issn.1671-6353.2019.03.004
[Absract] Objective Gender assignment in children with disorder of sex development is complex,and the decision should be made by the multidisciplinary team including the endocrinology,urology,and psychology,and the parents of the children.Among them,the evaluation of psychology has attracted more and more attention.A comprehensive assessment of children¡¯s gender identity and gender role can avoid the occurrence of adult gender anxiety.Nowadays there are a variety of sex role inventories for chil... [MORE...]
[PDF:768KB](586)
[184£­190] Clinical analysis and genetic screening of 41 children with 46,XY DSD
[Li Xueyan, Yin Xiaoming, Liu Xin, Yang Yi]
DOI:10.3969/j.issn.1671-6353.2019.03.005
[Absract] Objective Objective To explore the clinical presentations,diagnosis and therapy for 46,XY disorders of development (DSD).Methods A retrospective study was performed for 41 hospitalized 46,XY DSD patients from September 2011 to November 2018.Their clinical data were analyzed.And the relevant genes were sequenced for detecting gene mutations.Results Among them,the dominant social gender was male (n=28,68.3%) and female (n=13,31.7%).The initial diagn... [MORE...]
[PDF:1336KB](604)
[191£­195] Correlations between phenotype and monogenic mutation of 46,XY sexual development disorder
[Wu Dingwen1, Wu Dehua2, Zheng Jing1, Tian Hongjuan2, Zhang Ting1, Tao Chang2, Shen Yaping1, Chen Guangjie2, Tang Daxing2]
DOI:10.3969/j.issn.1671-6353.2019.03.006
[Absract] Objective Objective To explore the correlations between various phenotypes and monogenic mutations of 46,XY sexual development disorder (DSD) and provide valuable rationales for clinical application.Methods Genomic DNA was isolated from peripheral blood of 137 patients of 46,XY DSD.The exons of 2742 pathogenic genes were acquired by liquid phase capture technology.Variants on coding region and 10 bp around exon region of these genes were obtained by high throughput se... [MORE...]
[PDF:998KB](615)
[196£­201] Masculinizing plasty in 46,XY severely undervirilized genital
[Mao Yu, Xia Meng, Cai Yongchuan, Qin Daorui, Wang Xuejun, Chen Shaoji, Tang Yunman]
DOI:10.3969/j.issn.1671-6353.2019.03.007
[Absract] Objective Objective To summarize the procedure of masculinizing plasty in 46,XY severely undervirilized genital and explore the efficacy of plastic surgery.Methods A retrospective analysis was conducted for 64 children with severely undervirilized genital undergoing external genital masculinizing plastic surgery from January 2014 to November 2018.The karyotype was 46,XY in all cases.All external genitalia were perineal hypospadias with complete bifid scrotum and penos... [MORE...]
[PDF:1331KB](669)
[202£­205] Role of masculinization score in the assessment of 46,XY disorders of sex development
[Chen Guangjie, Tian Hongjuan, Wu Dehua, Tao Chang, Ru Wei, Wang Xiaohao, Wang Hengyou, Gao Lei, Xu Zeming, Tang Daxing]
DOI:10.3969/j.issn.1671-6353.2019.03.008
[Absract] Objective Objective To evaluate the role of masculinization score in the assessment of 46,XY disorders of sex development (DSD).Methods With a specially devised scoring system,external masculinization score (EMS) and internal masculinization score (IMS) were used for assessing 416 physical examination boys and 106 cases of 46,XY DSD.Results In physical examination boys,415(99.8%) had EMS ¡Ý 11.Among affected children,sex of rearing was boy (n=81) and girl... [MORE...]
[PDF:749KB](533)
[206£­210] Preliminary study on pathological features of gonadal gland in children with disorders of sex development and its clinical significance: a report of 106 cases
[Tao Chang, Tian Hongjuan, Gu Weizhong, Tang Hongfeng, Wu Dehua, Chen Guangjie, Xu Zheming, Ru Wei, Gao Lei, Shen Yiding, Tang Daxing]
DOI:10.3969/j.issn.1671-6353.2019.03.009
[Absract] Objective Objective To summarize the pathological features and clinical significance of gonads in children with disorders of sex development (DSD).Methods Clinical data of hospitalized DSD children receiving pathological examination of gonads were collected.According to the results of chromosomes,they were divided into three groups of sex chromosome DSD,46,XX DSD and 46,XY DSD.Results A total of 106 DSD children had gonadal pathologic biopsy/resection results.N... [MORE...]
[PDF:1208KB](599)
[211£­215] Preliminary study on the expression level and clinical significance of GPC1 in liver tissues of children with biliary atresia
[Sun Rong1, Wu Zhouguang2, Ye Yongqin2, Zhang Dahao2, Wang Bin2]
DOI:10.3969/j.issn.1671-6353.2019.03.010
[Absract] Objective Objective To explore the clinical significance of GPC1 in the pathogenesis of children with biliary atresia (BA).Methods A total of 35 hospitalized BA children at Children¡¯s Hospital of Shenzhen from July 2016 to February 2018 were recruited into observation group.And another 42 hospitalized children with congenital choledochal dilatation were selected as control group.The distribution of GPC1 protein in observation group was detected by immunohistochemistry... [MORE...]
[PDF:1009KB](431)
[216£­220] Application of transumbilical single-operator-hole laparoscopic pylorotomy for congenital hypertrophic pyloric stenosis
[Lu Chaoxiang1, Li Peng1, Li Mingming2, Miao Feng2, Li Zhongwen2]
DOI:10.3969/j.issn.1671-6353.2019.03.011
[Absract] Objective Objective To explore the advantages and disadvantages of three surgical procedures in the treatment of congenital hypertrophic pyloric stenosis.Methods Retrospective analysis was performed for 160 children with congenital hypertrophic pyloric stenosis from September 2012 to June 2017.Based upon specific surgical procedures,they were divided into three groups of bellybutton arcuate incision (n=52),traditional hole laparoscopy (n=56) and umbilica... [MORE...]
[PDF:1287KB](619)
[221£­224] Efficacy of mini-invasive negative pressure aspiration guided by B-ultrasound on limb lymphatic malformation in children
[Wang Yanni1, Qi Hongyan1, Zhang Xuejun2]
DOI:10.3969/j.issn.1671-6353.2019.03.012
[Absract] Objective Objective To research the efficacy of mini-invasive negative pressure aspiration under the guidance of B-ultrasound in the treatment of limb lymphatic malformations in children.Methods Twelve cases of limb lymphatic malformations between January 2015 and September 2017 were reviewed.There were 7 boys and 5 girls with an average age of (6.38¡À2.85)(3-11) years.The longest circumferences of affected limb as compared to healthy side were measured before operatio... [MORE...]
[PDF:956KB](476)
[225£­228] Outcome of vesicoureteral reflux in patients with posterior urethral valves after primary valve ablation
[Wang Chaoxu, Zhang Weiping, Song Hongcheng, Han Wenwen]
DOI:10.3969/j.issn.1671-6353.2019.03.013
[Absract] Objective Objective To summarize our institutional experience in the management of posterior urethral valves and analyze the effect of primary valve ablation on vesicoureteral reflux and hydronephrosis.Methods We retrospectively analyzed the records of 19 selected boys diagnosed with vesicoureteral reflux with posterior urethral valve from January 2010 to January 2016.The 19 patients were aged 6 months to 182 months[(27.4¡À7.2) months].The patitents who had reflux at p... [MORE...]
[PDF:839KB](530)
[229£­232] Bowel preparation of pediatric single balloon enteroscopy: a randomized,single-blind,controlled study
[Luo Yanhong, Yi Lichun, You Jieyu]
DOI:10.3969/j.issn.1671-6353.2019.03.014
[Absract] Objective Objective To explore a kind of safe,effective bowel preparation for children undergoing single balloon enteroscopy (SBE).Methods Retrograde route SBE was performed in 97 cases randomly assigned into A,B,C groups[group A:oral polyethylene glycol (PEG) plus simethicone;group B:oral PEG;group C:oral lactulose plus simethicone].For evaluating bowel cleansing effect,disease diagnostic rate,adverse reactions and complications were compared among groups A,B,C.Re... [MORE...]
[PDF:745KB](482)
[233£­236] The best treatment plan for neonatal necrotizing enterocolitis and related time
[Wang Wei1,2, Liu Gang1, Huang Liuming1, Yu Mengnan1, Qin Shengling1, Zhang Jing1, Xing Guodong1]
DOI:10.3969/j.issn.1671-6353.2019.03.015
[Absract] Objective Objective To discuss the postoperative treatment and the optimal timing of ostomy closure for neonatal necrotizing enterocolitis (NEC) patients with enterostoma.Methods Records of patients with NEC who received a enterostomy between 2011 to 2014 in our hospital were reviewed.Patients were divided in three groups:early ostomy closure(EC,within 90 d),medium ostomy closure (MC,90-180 d)and late ostomy closure(LC,after more than 180 d).Data were colleted include... [MORE...]
[PDF:744KB](755)
[237£­241] Analysis of related factors affecting neonatal sputum survival rate-Comparison between open surgery and endoscopic surgery
[Cheng Qianqian, Wu Yeming, Wang Jun, Pan Weihua, Chen Jie, Zhou Ying]
DOI:10.3969/j.issn.1671-6353.2019.03.016
[Absract] Objective Objective To explore the risk factors associated with the survival rate of congenital diaphragmatic hernia (CDH) children and the application of mini-invasive surgery.Methods The clinical data of 76 hospitalized CDH neonates undergoing surgery from January 2006 to March 2016 were retrospectively analyzed.And the relevant prognostic factors were analyzed.And open surgery and endoscopy were performed to evaluate the outcomes of endoscopic repair of neonatal CD... [MORE...]
[PDF:860KB](579)
[242£­246,249] Advances in autophagy regulation and neuroblastoma
[Qu Zhibo, Zhang Haoran]
DOI:10.3969/j.issn.1671-6353.2019.03.017
[Absract] Objective Neuroblastoma is one of the most common solid tumors in children and infants.The treatment of this disease is mainly surgery combined with chemotherapy,but the prognosis is not ideal.Therefore, the search for new therapeutic targets is one of the hot spots in current research.Recent studies have shown that abnormal regulation of autophagy is closely related to inflammatory response,energy metabolism,programmed cell death and resistance to tumor therapy.This paper summarizes t... [MORE...]
[PDF:793KB](442)
[247£­249]
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DOI:10.3969/j.issn.1671-6353.2019.03.018
[PDF:1207KB](472)
[250£­252]
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DOI:10.3969/j.issn.1671-6353.2019.03.019
[PDF:1023KB](512)