Li Kai.Current status and recent advances in drug therapies of Kaposiform hemangioendothelioma[J].Journal of Clinical Pediatric Surgery,,18():626-628.[doi:10.3969/j.issn.1671-6353.2019.08.002]
Click Copy

Current status and recent advances in drug therapies of Kaposiform hemangioendothelioma

Journal of Clinical Pediatric Surgery[ISSN:1671-6353/CN:43-1380/R] volume: 第18卷 Number: 2019 08 Page: 626-628 Column: 专家笔谈 Date of publication: 2019-08-25
Author(s):
Li Kai
Department of Surgery, Children’s Hospital of Fudan University, Shanghai, 201102, China
Keywords:
Hemangioendothelioma/TH; Drug Therapy
CLC:
R543;R732.2;R91
DOI:
10.3969/j.issn.1671-6353.2019.08.002
Abstract:
As a rare true angioma occurring predominantly in infants and toddlers,Kaposiform hemangioendothelioma (KH) is often manifested as local progression without a distant metastasis.One or multiple sites,including head,neck,torso and extremities,may be involved.Different from angioma,currently there is no domestic standard protocol for its treatments.And a definite international guideline is also lacking.Thus this paper was intended for reviewing and summarizing the diagnostic and therapeutic consensus of KH.Hopefully multi-center large-sample prospective trials are conducted for formulating the indications,guidelines and consensus of drug treatments for KH.

References:

1 孙玉环,车宗刚,郑家伟.ISSVA2018脉管异常新分类[J].中国口腔颌面外科杂志,2019,17(1):7-13.DOI:10.19438/j.cjoms.2019.01.003.Sun YH,Che ZG,Zheng JW.2018 newly revised ISSVA classification for vascular anomalies[J].China Journal of Oral & Maxillofacial Surgery,2019,17(1):7-13.DOI:10.19438/j.cjoms.2019.01.003.
2 Sarkar M,Mulliken JB,Kozakewich HP,et al.Thrombocytopenic coagulopathy (Kasabach-Merritt phenomenon) is associated with Kaposiform hemangioendothelioma and not with common infantile hemangioma[J].Plast Reconstr Surg,1997,100(6):1377-1386.
3 Chinello M,Di Carlo D,Olivieri F,et al.Successful management of Kaposiform hemangioendothelioma with long-term sirolimustreatment:a case report and review of the literature[J].Mediterr J Hematol Infect Dis,2018,10(1):e2018043.
4 Mazoyer E,Enjolras O,Laurian C,et al.Coagulation abnormalities associated with extensive venous malformations of the limbs:differentiation from Kasabach-Merritt syndrome[J].Clin Lab Haematol,2002,24(4):243-251.DOI:10.1046/j.1365-2257.2002.00447.x.
5 Kim T,Roh MR,Cho S,et al.Kasabach-merritt syndrome arising from tufted angioma successfully treated with systemic corticosteroid[J].Ann Dermatol,2010,22(4):426-430.DOI:10.5021/ad.2010.22.4.426.
6 Haisley-Royster C,Enjolras O,Frieden IJ,et al.Kasabach-merritt phenomenon:a retrospective study of treatment with vincristine[J].J PediatrHematol Oncol,2002,24(6):459-462.
7 Wang Z,Li K,Yao W,et al.Steroid-resistant kaposiform hemangioendothelioma:a retrospective study of 37 patients treated with vincristine and long-term follow-up[J].Pediatr Blood Cancer,2015,62(4):577-580.DOI:10.1002/pbc.25296.
8 Acharya S,Pillai K,Francis A,et al.Kasabachmerritt syndrome:management with interferon[J].Indian J Dermatol,2010,55(3):281-283.DOI:10.4103/0019-5154.70705.
9 Drolet B,Trenor CC,Brandão LR,et al.Consensus-derived practice standards plan for complicated Kaposiform hemangioendothelioma[J].J Pediatr,2013,163(1):285-291.DOI:10.1016/j.jpeds.2013.03.080.
10 Hammill AM,Wentzel M,Gupta A,et al.Sirolimus for the treatment of complicated vascular anomalies in children[J].Pediatr Blood Cancer,2011,57(6):1018-1024.DOI:10.1002/pbc.23124.
11 Kai L,Wang Z,Yao W,et al.Sirolimus,a promising treatment for refractory Kaposiform hemangioendothelioma[J].J Cancer Res Clin Oncol,2014,140(3):471-476.DOI:10.1007/s00432-013-1549-3.
12 O’rafferty C,O’regan GM,Irvine AD,et al.Recent advances in the pathobiology and management of Kasabach-Merritt phenomenon[J].Br J Haematol,2015,171(1):38-51.DOI:10.1111/bjh.13557.
13 Yao W,Li K,Wang Z,et al.Comparison of corticosteroid and vincristine in treating kaposiform hemangioendothelioma and tufted angioma:a systematic review and meta-analysis[J].Eur J Pediatr Surg,2018.DOI:10.1055/s-0038-1673708.
14 Schmid I,Klenk AK,Sparber-Sauer M,et al.Kaposiformhemangioendothelioma in children:a benign vascular tumor with multiple treatment options[J].World J Pediatr,2018,14(4):322-329.DOI:10.1007/s12519-018-0171-5.
15 Ji Y,Yang K,Chen S,et al.Musculoskeletal complication in kaposiform hemangioendothelioma without Kasabach-Merritt phenomenon:clinical characteristics and management[J].Cancer Manag Res,2018,10:3325-3331.DOI:10.2147/CMAR.S171223.

Memo

收稿日期:2019-04-15。
基金项目:上海市卫生系统优秀人才培养计划（编号：2017BR052）

Last Update: 1900-01-01