Zhu Tong,Li Lianyong,Liu Tianjing,et al.Correlations between prematurity and vitamin D and bone metabolic markers in neonates[J].Journal of Clinical Pediatric Surgery,,19():420-425.[doi:10.3969/j.issn.1671-6353.2020.05.009]
Correlations between prematurity and vitamin D and bone metabolic markers in neonates
- Keywords:
- Premature Birth; Bone Diseases; Metabolic; Vitamin D; Evaluation Studies
- CLC:
- R722.6;R681;R591.44
- Abstract:
- Objective To measure the levels of vitamin D and bone metabolic markers and explore the correlation between prematurity,vitamin D and bone metabolic markers in neonates.Methods A total of 1,304 women delivered at Shengjing Hospital,China Medical University from November,2012 to October,2013.Finally 814 neonates including 24 very preterm,134 mildly preterm and 656 term were recruited for analysis.Enzyme-linked immunosorbent assay (ELISA) kit was utilized for measuring the serum levels of 25-hydroxyitamin D(25-(OH)-D) and 25-(OH)-D,osteoprotegerin (OPG),parathyroid hormone (PTH) and C-telopeptides typeⅠcollagen (CTX).Results Significant differences existed in body weight,body length,head circumference and chest circumference between term and very/mildly preterm groups (P<0.01).Significant differences existed in the levels of vitamin D and PTH level between very preterm and mildly preterm,mildly preterm and term and very preterm and term groups (P<0.01).Significant difference existed in the level of OPG between very preterm and term and very preterm and mildly preterm groups (P<0.01).In two preterm groups,25-(OH)-D concentration showed a significant positive correlation with OPG and CTX concentrations (r=0.563,0.581,P<0.001) and a negative correlation with PTH (r=-0.621,P<0.001).There was a negative correlation between concentrations of OPG and PTH (r=0.563,0.581,P<0.001) and a positive correlation between OPG and CTX (r=0.653,P<0.001).PTH concentration had a negative correlation of CTX concentration (r=-0.520,P<0.001).Conclusion Disorder of osteogenesis and hyperactivity of osteoclast in premature may play a key role in their susceptibilities to metabolic bone disease.Vitamin D deficiency may be one of the causes of metabolic bone disease.Measuring the serum levels of 25-(OH)-D and bone metabolic markers can reflect the condition of bone metabolism in premature neonates.
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Memo
收稿日期:2019-04-14。
基金项目:国家自然科学基金（编号：81572095）；国家重点研发计划项目（编号：2016YFC1000505）
通讯作者:赵群,Email:zhaoqunorthopedics@163.com