Yu Xingyu,Gu Song,Li Yunjie,et al.Recent advance of Wnt/β-catenin signaling pathway in hepatoblastoma[J].Journal of Clinical Pediatric Surgery,2022,21(07):688-691.[doi:10.3760/cma.j.cn101785-202107049-018]
肝母细胞瘤Wnt/β-catenin信号通路研究进展
- Title:
- Recent advance of Wnt/β-catenin signaling pathway in hepatoblastoma
- 关键词:
- 肝肿瘤/诊断; 肝肿瘤/外科学; Wnt信号通路/生理学; β连环素/生理学
- 摘要:
- 肝母细胞瘤（hepatoblastoma，HB）是儿童最常见的肝脏恶性肿瘤，近30年来HB的发病率迅速攀升。目前手术切除和以顺铂为基础的化疗是HB的主要治疗手段。研究表明，Wnt/β-catenin信号通路在肝细胞发生以及肝脏发育、再生和损伤修复等过程中发挥重要作用。同时，Wnt/β-catenin信号通路异常作为HB的主要标志，影响肿瘤的发生发展，且该通路中的一些分子具有作为靶点的潜力。本文对肝母细胞瘤Wnt/β-catenin信号通路的研究进展进行整合，旨在阐明Wnt/β-catenin信号通路的机制及其与HB发生发展的关系，总结Wnt/β-catenin信号通路在HB诊断、治疗、预后等方面的作用，为HB的临床治疗提供参考依据。
- Abstract:
- Hepatoblastoma (HB) is the most common liver malignancy in children and its incidence has been rising over the last three decades.Surgery excision and cisplatinum-based chemotherapy are currently major treatments for HB.Numerous researches have demonstrated that Wnt signaling pathway plays important roles in hepatocyte generation, liver development, regeneration and injury repair.Meanwhile, abnormal Wnt/β-catenin signaling pathway, as a major marker of HB, affects the occurrence and development of tumors.And some molecules in the pathway have potential targets.By integrating domestic and foreign researches of HB and Wnt/β-catenin signaling pathway, this review elucidated the mechanism of Wnt/β-catenin signaling pathway, examined its relationship with the occurrence and development of HB, summarized the roles of Wnt/β-catenin signaling pathway in the diagnosis, treatment and prognosis of HB and provided novel rationales for clinical treatment of HB.
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备注/Memo
收稿日期:2021-07-26。
基金项目:1.2021年度国家临床重点专科建设项目：国家儿童医学中心（基于提高临床服务能力为导向的儿童肿瘤多学科合作诊疗体系建设）（2021）；2.浦东新区科技发展基金民生科研（医疗卫生）项目（PKJ2017-Y04）；3.上海交通大学医学院第15期大学生创新训练计划项目（1521Y051，S202210248303）
通讯作者:顾松,Email:gusong@shsmu.edu.cn