Tan Qin,Zhang Mingman.Research progress on prognostic factors of hepatoblastoma in children[J].Journal of Clinical Pediatric Surgery,2021,20(05):474-477.[doi:10.12260/lcxewkzz.2021.05.015]
儿童肝母细胞瘤预后相关因素的研究进展
- Title:
- Research progress on prognostic factors of hepatoblastoma in children
- Keywords:
- Liver Neoplasms/SU; Prognosis; Root Cause Analysis; Child
- 分类号:
- R735.7;R726
- 摘要:
- 肝母细胞瘤（hepatoblastoma，HB）是儿童最常见的肝脏原发性恶性肿瘤，虽然高危患者的治疗结局仍不理想，但近年来其整体预后已得到了极大改善，目前已使用化疗、手术切除程度、PRETEXT分期、病理分型、年龄、种族、基因等指标对HB患者的预后进行评估，但仍有较多因素的预后价值尚未明确。近年来国内外学者在研究HB预后相关因素方面取得了一些新的研究成果，使得HB的远期疗效评估成为可能。本文针对儿童肝母细胞瘤预后相关因素的研究进展进行综述。
- Abstract:
- Hepatoblastoma (HB) is the most common primary malignant tumor of the liver in children.Its prognosis has been greatly improved in recent years,but the treatment outcome of high-risk patients is still not ideal.At present,the prognosis of HB has been evaluated using chemotherapy,degree of surgical resection,PRETEXT staging,pathological classification,age,race,gene and other indicators,but the prognostic value of many factors is still unclear.In recent years,domestic and foreign scholars have made some new research results in the study of HB-related prognostic factors,making it possible to evaluate the long-term efficacy of HB.This article will review the research progress on prognostic factors of childhood hepatoblastoma.
参考文献/References:
1 Kehm RD,Osypuk TL,Poynter JN,et al.Do pregnancy characteristics contribute to rising childhood cancer incidence rates in the United States?[J].Pediatr Blood Cancer,2018,65(3):10.1002/pbc.26888.DOI:10.1002/pbc.26888.
2 Hung GY,Lin LY,Yu TY,et al.Hepatoblastoma incidence in Taiwan:A population-based study[J].J Chin Med Assoc,2018,81(6):541-547.DOI:10.1016/j.jcma.2017.11.012.
3 Towbin AJ,Meyers RL,Woodley H,et al.2017 PRETEXT:radiologic staging system for primary hepatic malignancies of childhood revised for the Paediatric Hepatic International Tumour Trial (PHITT)[J].Pediatr Radiol,2018,48(4):536-554.DOI:10.1007/s00247-018-4078-z.
4 Feng J,Polychronidis G,Heger U,et al.Incidence trends and survival prediction of hepatoblastoma in children:a population-based study[J].Cancer Commun (Lond),2019,39(1):62.DOI:10.1186/s40880-019-0411-7.
5 Feng J,He Y,Wei L,et al.Assessment of Survival of Pediatric Patients With Hepatoblastoma Who Received Chemotherapy Following Liver Transplant or Liver Resection[J].JAMA Netw Open,2019,2(10):e1912676.DOI:10.1001/jamanetworkopen.2019.12676.
6 Van Tornout JM,Buckley JD,Quinn JJ,et al.Timing and magnitude of decline in alpha-fetoprotein levels in treated children with unresectable or metastatic hepatoblastoma are predictors of outcome:a report from the Children’s Cancer Group[J].J Clin Oncol,1997,15(3):1190-1197.DOI:10.1200/JCO.1997.15.3.1190.
7 Cai HY,Yu B,Feng ZC,et al.Clinical significance of CD44 expression in children with hepatoblastoma[J].Genet MolRes,2015,14(4):13203-13207.DOI:10.4238/2015.October.26.16.
8 Kiruthiga KG,Ramakrishna B,Saha S,et al.Histological and immunohistochemical study of hepatoblastoma:correlation with tumour behaviour and survival[J].J Gastrointest Oncol,2018,9(2):326-337.DOI:10.21037/jgo.2018.01.08.
9 中华医学会病理学分会儿科病理学组,福棠儿童医学发展研究中心病理专业委员会.肝母细胞瘤病理诊断专家共识[J].中华病理学杂志,2019,48(3):176-181.DOI:10.3760/cma.j.issn.0529-5807.2019.03.002. Group of Pediatric Pathology,Branch of Pathology,Chinese Medical Association;Pathology Specialist Committee of Futang Research Center of Pediatric Development:Chinese expert group consensus on pathological diagnosis of hepatoblastoma[J].Chin J Pathol,2019,48(3):176-181.DOI:10.3760/cma.j.issn.0529-5807.2019.03.002.
10 Lim ⅡP,Bondoc AJ,Geller JI,et al.Hepatoblastoma The Evolution of Biology,Surgery,and Transplantation[J].Children (Basel),2018,6(1):1.DOI:10.3390/children6010001.
11 Kremer N,Walther AE,Tiao GM.Management of hepatoblastoma:an update[J].Curr Opin Pediatr,2014,26(3):362-369.DOI:10.1097/MOP.0000000000000081.
12 Meyers RL,Maibach R,Hiyama E,et al.Risk-stratified staging in paediatric hepatoblastoma:a unified analysis from the Children’s Hepatic tumors International Collaboration[J].Lancet Oncol,2017,18(1):122-131.DOI:10.1016/S1470-2045(16)30598-8.
13 Czauderna P,Haeberle B,Hiyama E,et al.The Children’s Hepatic tumors International Collaboration (CHIC):Novel global rare tumor database yields new prognostic factors in hepatoblastoma and becomes a research model[J].Eur J Cancer,2016,52:92-101.DOI:10.1016/j.ejca.2015.09.023.
14 Koh KN,Park M,Kim BE,et al.Prognostic implications of serum alpha-fetoprotein response during treatment of hepatoblastoma[J].Pediatr Blood Cancer,2011,57(4):554-560.DOI:10.1002/pbc.23069.
15 Wang TY,Han YL,Gao YJ,et al.Retrospective Analysis of Childhood Hepatoblastoma in a Single Centre in China[J].Clin Oncol (R Coll Radiol),2019,31(7):471-478.DOI:10.1016/j.clon.2019.03.044.
16 王大斌,张可仞,贾慧敏,等.影响肝母细胞瘤儿童术后生存的因素分析[J].国际儿科学杂志,2019,46(8):612-616.DOI:10.3760/cma.j.issn.1673-4408.2019.08.017. Wang DB,Zhang KQ,Jia HM,et al.Analysis of factors affecting postoperative survival of children with hepatoblastoma[J].Int J Pediatr,2019,46(8):612-616.DOI:10.3760/cma.j.issn.1673-4408.2019.08.017.
17 Maibach R,Roebuck D,Brugieres L,et al.Prognostic stratification for children with hepatoblastoma:the SIOPEL experience[J].Eur J Cancer,2012,48(10):1543-1549.DOI:10.1016/j.ejca.2011.12.011.
18 葛丽丽,宋银森,张现伟.肝母细胞瘤甲胎蛋白、病理学标志物的表达变化与预后的关系[J].实验与检验医学,2019,37(1):18-22.DOI:10.3969/j.issn.1674-1129.2019.01.006. Ge LL,Song YS,Zhang XW.The relationship between the expression of alpha-fetoprotein and pathological markers and prognosis in hepatoblastoma[J].Experimental and Laboratory Medicine,2019,37(1):18-22.DOI:10.3969/j.issn.1674-1129.2019.01.006.
19 Peng HX,Yang L,He BS,et al.Combination of preoperative NLR,PLR and CEA could increase the diagnostic efficacy for I-Ⅲ stage CRC[J].J Clin Lab Anal,2017,31(5):e22075.DOI:10.1002/jcla.22075.
20 Peng H,Luo X.Prognostic significance of elevated pretreatment systemic inflammatory markers for patients with prostate cancer:a meta-analysis[J].Cancer Cell Int,2019,19:70.DOI:10.1186/s12935-019-0785-2.
21 Wang TY,Han YL,Gao YJ,et al.Retrospective Analysis of Childhood Hepatoblastoma in a Single Centre in China[J].Clin Oncol (R Coll Radiol),2019,31(7):471-478.DOI:10.1016/j.clon.2019.03.044.
22 姚东亚,罗源,盛光耀.儿童肝母细胞瘤36例预后分析[J].临床儿科杂志,2017,35(2):121-124.DOI:10.3969/j.issn.1000-3606.2017.02.011. Yao DY,Luo Y,Sheng GY.Prognostic analysis of hepatoblastoma in children[J].Journal of Clinical Pediatrics,2017,35(2):121-124.DOI:10.3969/j.issn.1000-3606.2017.02.011.
23 Dall’Igna P,Brugieres L,Christin AS,et al.Hepatoblastoma in children aged less than six months at diagnosis:A report from the SIOPEL group[J].Pediatr Blood Cancer,2018,65(1):10.1002/pbc.26791.DOI:10.1002/pbc.26791.
24 吴琳琳,禚孝颖,刘洁,等.行根治性切除术的儿童肝母细胞瘤54例预后因素分析[J].精准医学杂志,2020,35(2):138-141.DOI:10.13362/j.jpmed.202002011. Wu LL,Luo XY,Liu J,et al.Analysis of prognostic factors in 54 children with hepatoblastoma undergoing radical resection[J].J Precis Med,2020,35(2):138-141.DOI:10.13362/j.jpmed.202002011.
25 张谊,黄东生,张伟令,等.IN1基因表达与儿童肝母细胞瘤临床特点及预后的相关性研究[J].中华实用儿科临床杂志,2019,34(15):1156-1159.DOI:10.3760/cma.j.issn.2095-428X.2019.15.008. Zhang Y,Huang DS,Zhang WL,et al.Study on the relationship between IN1 gene expression and clinical characteristics and prognosis of hepatoblastoma in children[J].Chin J Appl Clin Pediatr,2019,34(15):1156-1159.DOI:10.3760/cma.j.issn.2095-428X.2019.15.008.
26 Perilongo G,Malogolowkin M,Feusner J.Hepatoblastoma clinical research:lessons learned and future challenges[J].Pediatr Blood Cancer,2012,59(5):818-821.DOI:10.1002/pbc.24217.
27 杨维,任清华,秦红,等.儿童肝母细胞瘤精准肝切除手术效果评价[J].临床小儿外科杂志,2020,19(5):392-397.DOI:10.3969/j.issn.1671-6353.2020.05.004. Yang W,Ren QH,Qin H,et al.Evaluation of the effect of precision hepatectomy in children with hepatoblastoma[J].J Clin Ped Sur,2020,19,(5):392-397.DOI:10.3969/j.issn.1671-6353.2020.05.004.
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备注/Memo
收稿日期:2020-10-04。
基金项目:重庆市科学技术局资助项目（编号：cstc2018jscx-msyb0182）
通讯作者:张明满,Email:zhangmingman-a@163.com