Zhan Jianghua,Wang Zhiru.Focusing upon hot issues of diagnosing and treating biliary atresia[J].Journal of Clinical Pediatric Surgery,2023,22(03):201-204.[doi:10.3760/cma.j.cn101785-202212026-001]
聚焦胆道闭锁诊疗相关热点问题
- Title:
- Focusing upon hot issues of diagnosing and treating biliary atresia
- Keywords:
- Biliary Atresia; Cholangitis; Laparoscopes; Prognosis
- 摘要:
- 胆道闭锁(biliary atresia,BA)是指以肝内、外胆管进行性炎症和纤维化为特征的新生儿及婴儿期严重肝胆系统疾病,Kasai手术为BA的首选治疗方案,但约60%的患儿手术后仍会进一步发展为肝功能衰竭,最终需通过肝移植挽救生命。目前对于BA病因及发病机制的了解仍不够彻底,对于术后并发症的预防也并无良策,但一直以来争议较大的腔镜下Kasai手术取得了令人满意的效果。本文对当前困扰研究人员的BA诊疗相关热点问题进行评述,为探寻BA未来的研究方向提供思路。
- Abstract:
- As a serious disease of hepatobiliary system in neonates and infants,biliary atresia (BA) is characterized by progressive inflammation and fibrosis of intra-and extrahepatic bile ducts.Kasai operation has remained a preferred treatment option.However,around 60% of children with postoperative liver fibrosis may progress further and eventually liver transplantation is often required for saving lives.Our current understandings of the etiology and pathogenesis of BA are insufficient.And there is no proper way of preventing postoperative complications.Though as a subject of much controversy,Laparoscopic Kasai procedure has achieved satisfactory outcomes.This review focused upon current hot issues of researchers to provide rationales for future researches of BA.
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备注/Memo
收稿日期:2022-12-9。
基金项目:天津市科技局重大专项(21ZXGWSY00070);新疆维吾尔自治区自然科学基金(2022D01A27、2021D01A38);天津大学儿童医院面上项目(Y2020002)
通讯作者:詹江华,Email:zhanjianghuatj@163.com