Wang Pei,Feng Jiexiong.The antibiotics treatment of cholangitis Post-Kasai Portoenterostomy: A multi-center study protocol[J].Journal of Clinical Pediatric Surgery,2019,18(11):922-926.[doi:10.3969/j.issn.1671—6353.2019.11.006]
胆道闭锁术后胆管炎抗生素分级治疗的多中心研究方案
- Title:
- The antibiotics treatment of cholangitis Post-Kasai Portoenterostomy: A multi-center study protocol
- Keywords:
- Biliary Atresia/DT; Cholangitis; Antibiotic Prophylaxis; Multicenter Studies; Research Design
- 分类号:
- R657.4+4;R575.7
- 摘要:
- 胆管炎是BA术后最常见的并发症，发生率为60%~90%，反复发作胆管炎是影响BA患儿术后生活质量的重要危险因素。目前胆管炎的治疗多为经验性用药，尚无统一治疗指南。本研究拟通过多中心、前瞻性随机对照试验研究对不同程度胆管炎进行抗生素分级治疗。研究拟招募190名胆道闭锁术后胆管炎患儿，根据胆管炎严重程度随机分为对照组（n=95）和试验组（n=95），对照组统一接受抗生素治疗，试验组根据胆管炎严重程度接受分级抗生素治疗，治疗3 d、7 d后评估各组胆管炎患儿的治疗效果。这一多中心前瞻性研究将为BA术后胆管炎患儿抗生素规范化治疗提供循证医学层面的证据。
- Abstract:
- Cholangitis is the most common postoperative complication of BA,and the incidence is about 60%~90%.Recurring cholangitis is an important risk factor affecting the postoperative life quality of children with BA.However,there is no unified guideline for the severity of cholangitis and the related treatment.Therefore,this study is a multi-center and prospective research,intending to clarify the antibiotics treatment of cholangitis.A total of 190 cholangitis children will be recruited and randomized into control group(n=95) and experimental group(n=95),all control groups were treated with the same antibiotics,and the experimental group were treated with different antibiotics according to the severity of cholangitis,then evaluate the cure rate 3 days and 7 days later.This multi-center prospective study may provide a reliable reference for the standardized treatment of cholangitis.
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备注/Memo
收稿日期:2017-04-18。
基金项目:国家自然科学基金（编号：81873541）
通讯作者:冯杰雄,Email:fengjiexiong@126.com