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[101－103] Reflections on surgical treatment of neuroblastoma

[Wang Huanmin]

DOI:10.3760/ama.j.cn.101785-202202032-001

[Absract] Objective Neuroblastoma surgery is rather complex, lethal and challenging.There are practical difficulties in scientifically evaluating its surgical performance.And clinicians cast doubts about its contribution to ultimate patient survival.Surgical techniques should be constantly improved to boost the surgical efficacy for neuroblastoma through developing a variety of new technologies and refining the application of mini-invasive surgery. [MORE...]

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[104－107] Surgical treatment of neuroblastoma-problems and challenges

[Li Yong, Liu Denghui, Li Ming, Xiao Yalin]

DOI:10.3760/cma.j.cn.101785-202201025-002

[Absract] Objective Pediatric Neuroblastoma(NB)is a heterogeneous solid tumor of the sympathetic nervous system.It most commonly develops in the abdomen.Surgery plays an important role in multidisciplinary treatment with the principal goal of removing the tumor focus while minimizing damage to surrounding structures.There has not been a consensus on the best surgical technique, and the operative approach largely depends on the anatomical location and the extension of the mass.This review summari... [MORE...]

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[108－114] Evaluation of chemotherapy for reducing operative complications of medium and high risk retroperitoneal neuroblastoma based on imaging-defined risk factor

[Hu Jiajian¹, Sun Jihang², Yang Shen¹, Chen Yiwei¹, Wang Huanmin¹]

DOI:10.3760/cma.j.cn.101785-201909059-003

[Absract] Objective Objective To research the role of neoadjuvant chemotherapy in reducing operative complications of medium and high risk retroperitoneal neuroblastoma based on the concept of imaging-defined risk factor (IDRF).Methods The whole clinical and surgical data of children with medium and high risk retroperitoneal neuroblastoma who underwent standardized chemotherapy and surgery from June 2016 to June 2017 in Beijing Children’s Hospital were retrospectively analyzed.... [MORE...]

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[115－120] Single-center analysis of clinical features and prognosis of neuroblastoma children with bone metastasis

[Ma Yue, Wang Shan, Li Changchun, Yang Chao, Zhao Zhenzhen, Du Xiaoyu, Deng Xiaobin, Kong Xiangru, Lǔ Linya, Zhang Jun, Peng Liang, Du Yifei, Zhou Jianwu, Sun Jian]

DOI:10.3760/cma.j.cn.101785-202105011-004

[Absract] Objective Objective To analyze the clinical features and prognostic factors of neuroblastoma (NB)children with bone metastasis.Methods The clinical data of 97 cases of NB children with bone metastasis treated in the Department of surgical Oncology, Children’s Hospital of Chongqing Medical University from December 2013 to December 2020 were retrospectively analyzed to compare the influence of different factors on the prognosis of the children.Results Among the 9... [MORE...]

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[121－127] Risk factors related to 3-year EFS in International Neuroblastoma Staging System stage 4 neuroblastoma patients

[Liu Tao, Sheng Qingfeng, Liu Jiangbing, Xu Weijue, Jiang Shayi, Yang Xiujun, Lü Zhibao]

DOI:10.3760/cma.j.cn.101785-202011036-005

[Absract] Objective Objective To explore the risk factors related to 3-year event-free survival (EFS) in patients with International Neuroblastoma Staging System (INSS) stage 4 neuroblastoma (NB).Methods A retrospective analysis of 68 patients diagnosed and completely evaluated with INSS stage 4 neuroblastoma from April 2014 to April 2020 was performed.Patients’ information including age, gender, neuron specific enolase (NSE), 1actate dehydrogenase (LDH), vanillylmandelic acid ... [MORE...]

[PDF:4190KB](355)

[128－135] Role of SNHG7-miR-653-5p-STAT2 feedback loop in regulating neuroblastoma progression

[Yang Bingyi¹, Liu Xiaomei¹, Chen Xin¹, Chen Weiming², Fan Xu³, Li Fujiang¹, Lu Hongting⁴]

DOI:10.3760/cma.j.cn.101785-201910074-006

[Absract] Objective Objective To explore the role of lncRNASNHG7 in the progression of neuroblastoma (NB) and examine the regulatory role of snhg7-mir-653-5p-stat2 feedback pathway in NB.Long noncoding RNAs (lncRNAs) have been implicated in the pathogenesis of various cancers, including neuroblastoma (NB).However, the role of lncRNASNHG7 in NB progression remains elusive.Methods The expression of SNHG7 in NB tissues and cells was detected by quantitative realtime-polymerase cha... [MORE...]

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[136－140] Two different surgical approaches of laparoscopic adrenalectomy for children with adrenal neuroblastoma

[Ding Ning¹, Rao Pinde¹, Wu Wenbo¹, Huang Jinshi², Zhang Shouhua³, Tang Jing¹, Xiong Chunfeng¹, Wang Jianghua¹]

DOI:10.3760/cma.j.cn.101785-202012030-007

[Absract] Objective Objective To evaluate the reliability and safety of two different surgical approaches of laparoscopic adrenalectomy for children with adrenal neuroblastoma.Methods A retrospective study was performed for five children undergoing laparoscopic adrenalectomy from February 2018 to August 2020.There were 6 boys and 3 girls with an average age of 22(1-65) months.The involved side was left (n=3) and right (n=6).There were abdominal pain (n=2), ... [MORE...]

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[141－145] Pathogenesis and clinical characteristics of congenital neuroblastoma

[Zhang Meihui¹, Jiang Dapeng²]

DOI:10.3760/cma.j.cn.101785-202105045-008

[Absract] Objective As the most common extracranial solid tumor in children, neuroblastoma originates from adrenal medulla or sympathetic ganglion.Congenital neuroblastoma accounts for 5% of all neuroblastomas and most patients are diagnosed within the first month after birth.Neonates have a unique disease course as compared to children aged over 1 year.This review summarized the pathogenesis and clinical presentations of congenital neuroblastoma, as well as biological factors of predicting the ... [MORE...]

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[146－150] Anticoagulant therapy of heparin plus plavix after Rex shunt for children with extrahepatic portal venous obstruction

[Zhang Jinshan, Li Long]

DOI:10.3760/cma.j.cn.101785-202102027-009

[Absract] Objective Objective To explore the effectiveness of heparin plus plavix anticoagulant therapy in improving the prognosis and shunt patency of Rex shunt.Methods From January 2010 to September 2019, 51 children with extrahepatic portal venous obstruction (EHPVO) underwent portal cavernoma-Rex shunt with an interposition of grafted portal vessel.They were divided into two groups of anticoagulant and non-anticoagulant.There were 32 boys and 19 girls with a median operativ... [MORE...]

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[151－155] Role of contrast-enhanced voiding urosonography in the diagnosis of pediatric vesicoureteral reflux

[Zou Xiangyu¹, Sun Peixuan², Shi Jing², Zhao Haiteng¹, Jiang Dapeng¹, Zhong Liang¹, Du Jun², Sun Jie¹]

DOI:10.3760/cma.j.cn.101785-202006044-010

[Absract] Objective Objective To determine the value of contrast-enhanced voiding urosonography (CeVUS) for diagnosing vesicoureteral reflux (VUR) in children.Methods A total of 116 cases (232 pyelo-ureter units, PUUs) of suspicious VUR and postoperative children were admitted from December 2018 to June 2020.The safety and positive rate were analyzed.Twenty-four children (48 PUUs) were compared with voiding cystourethrography (VCUG) for its sensitivity, specificity, and consist... [MORE...]

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[156－161] Analysis of influencing factors and predictive modeling of renal function in children with hydronephrosis

[Lin Ziyong, Yang Yi, Yin Xiaoming, Liu Xin, Zhao Qian]

DOI:10.3760/cma.j.cn.101785-202012071-011

[Absract] Objective Objective To explore the influencing factors of changes in renal function of children with hydronephrosis after pyeloneoplasty and establish a model for predicting the changes of renal function.Methods From January 1, 2011 to August 1, 2017, a retrospective review was conducted for 136 children with unilateral hydronephrosis.The relationship was examined between preoperative differential renal function (DRF), preoperative renal aspect ratio and postoperative... [MORE...]

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[162－169] Minimally invasive transthoracic device closure of congenital heart disease navigated by transesophageal echocardiogram: Long-term follow-up results

[Lü Bei, Chen Rui, Ren Yueyi, Hou Kefeng, Duan Shuhua, Ji Zhixian, Cao Qian, Di Yong, Wu Qin, Xing Quansheng]

DOI:10.3760/cma.j.cn.101785-202104076-012

[Absract] Objective Objective To summarize the clinical experience and long-term follow-up result of minimally invasive transthoracic device closure (MITDC) of congenital heart disease (CHD), and evaluate its long-term efficacy and safety.Methods A retrospective review was performed on the clinical data of patients with CHD undergoing MITDC navigated by transesophageal echocardiogram (TEE) from March 2007 to December 2017.The patients were continuously followed up by December 3... [MORE...]

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[170－173] Airway management of thoracoscopic surgery for recurrent tracheoesophageal fistula in children

[Song Lan’e, Zhu Xiaohong]

DOI:10.3760/cma.j.cn.101785-202011036-013

[Absract] Objective Objective To explore the anesthetic airway management for thoracoscopic surgery (TS) of recurrent tracheoesophageal fistula (rTEF).Methods A retrospective analysis was conducted on the clinical data of 29 patients of rTEF undergoing thoracoscopic repair.Information on preoperative conditions, one-lung ventilation methods, and location and size of the fistula were collected.Changes of PETCO₂ and SpO₂ at 6 time points (before one-lung ven... [MORE...]

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[174－178] Treatment of radial neck fracture in children by percutaneous K-wire pry plus intramedullary needle internal fixation under ultrasonic guidance

[Pan Bowen, Zhao Guoqiang, Zhu Ming, Zhao Xufei, Chen Gang]

DOI:10.3760/cma.j.cn.101785-202104073-014

[Absract] Objective Objective To explore the significance of ultrasonography and intramedullary needle in the treatment of radial neck fractures and provide a mini-invasive and radiation-free treatment for radial neck fractures in children. Methods From August 2018 to December 2019, clinical data were reviewed for 16 children hospitalized with Juedet Ⅲ/Ⅳ radial neck fractures.There were 6 boys and 10 girls with an average age of 98(45-135) months.And the involved side was left ... [MORE...]

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[179－185] Ruptured Omphalocele with prolapsed-intestinal volvulus with incarcerated necrosis and ileal atresia: a case report and literature review

[Chen Feng¹, Fu Zhong¹, Fang Tao², Huang Haijin¹, Zeng Linshan¹, Liu Qian³]

DOI:10.3760/cma.j.cn.101785-202012030-015

[Absract] Objective Objective To explore the experience of diagnosis and treatment of Ruptured Omphalocele(RO) in order to improve the level of diagnosis and treatment of the disease by pediatric surgeons.Methods The clinical data of a 38-week-term infant with RO were retrospectively analyzed.The databases of Pubmed, Springer Link, Google Scholar, CBM, CNKI, Wanfang and CQVIP were searched for the relevant publications using such key words as omphalocele and ruptured.Also a sys... [MORE...]

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[186－190] Recent advances of non-surgical treatment of Hirschsprung’s disease

[Wang Ji, Li Zhi]

DOI:10.3760/cma.j.cn.101785-202104064-016

[Absract] Objective As a congenital bowel disorder, Hirschsprung’s disease (HSCR) is characterized by the absence of intestinal ganglion cells with a prevalence of 1/5000 and a male-to-female ratio of 4:1.Its treatment options include surgery and non-surgical measures.The major treatment remains surgical resection by removing ganglion-free intestine and transitional segments.Domestic and foreign scholars actively exploring non-surgical option have concluded that it plays an important role in res... [MORE...]

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[191－195] Progress in the treatment of Ewing’s sarcoma family tumor

[Wang Yang, Dong Rui]

DOI:10.3760/cma.j.cn.101785-201909060-017

[Absract] Objective As a common malignant bone tumor in children, Ewing’s sarcoma family tumor (ESFT) has the clinical characteristics of aggressiveness, osteolysis and obvious metastatic tendency.A multidisciplinary therapeutic approach has markedly improved the prognosis of ESFT patients.Despite aggressive interventions, still 20-40% of patients have local diseases and nearly 80% are metastatic without any significant efficacy.With a rapid development of biotargeted therapies, some patients wi... [MORE...]

[PDF:3881KB](254)

[196－198]

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DOI:10.3760/cma.j.cn.101785-202111053-018

[PDF:2434KB](267)

[199－200] A case report of longitudinal arc epiphysis of bilateral protruding toes

[Qian Yu¹, Jiang Hua²]

DOI:10.3760/cma.j.cn.101785-202101015-019

[PDF:1533KB](204)