Zhu Weiwen,Sun Jie.Correlations of the expression of androgen receptor in appendix testis with undescended testis and testis development[J].Journal of Clinical Pediatric Surgery,,20():754-760.[doi:10.12260/lcxewkzz.2021.08.010]
Correlations of the expression of androgen receptor in appendix testis with undescended testis and testis development
- Keywords:
- Cryptorchidism; Appendix Testis; Receptors; Androgen
- CLC:
- R726.972.2;R726.9
- Abstract:
- Objective To explore the expression of androgen receptor in appendix testis in cryptorchidism and examine a possible relation between androgen receptor and testis descend and testis development. Methods Clinical data were collected from cryptorchidism patients from November 2019 to May 2020. Appendix testis was collected from hospitalized children of orchipexy. They were divided into abdominal testis, upper inguinal and lower inguinal testis according to the location of testis. The preoperative results of scrotum ultrasound were collected. The average optical density was calculated and statistic analysis performed for evaluating the relation between testis length and the expression level of androgen receptor in appendix testis. Results All androgen receptors in appendix testis were positive in acquired cryptorchidism children and it was merely 30.7% positive in congenital bilateral cryptorchidism counterparts (P<0.001). In those with positive androgen receptor, abdominal testis group had a mean optical density of 22×10-4(2×10-4, 154×10-4), and it was 115×10-4(46×10-4, 315×10-4) in upper inguinal testis group. Moreover, the length of affected side of testis had a positive correlation with the average optical density in appendix testis. Conclusion The expression level of androgen receptor in appendix testis is probably correlated with testis location/ development. Bilateral cryptorchidism has a close relation with hormone. Examining androgen receptor in appendix testis help researchers understand the descending of testis. This study hints at a possible relation between testis descend and appendix testis. It may facilitate a mechanistic understanding of cryptorchidism in the future.
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Memo
收稿日期:2020-08-14。
基金项目:国家自然科学基金青年项目（编号：81900618）；上海"科技创新行动计划"扬帆计划（编号：18YF1415000）
通讯作者:孙杰,Email:ppdrsun@gmail.com