Xu Yongkang,Yun Ye,Zhao Yongxiang,et al.Applicable value of serum c-reactive protein,interleukin 6 and procalcitonin in acute complex pediatric appendicitis[J].Journal of Clinical Pediatric Surgery,,20():60-64.[doi:10.12260/lcxewkzz.2021.01.012]
Applicable value of serum c-reactive protein,interleukin 6 and procalcitonin in acute complex pediatric appendicitis
- Keywords:
- Appendicitis/DI; Appendicitis/IM; C-Reactive Protein; Interleukin 6; Procalcitonin; Child
- CLC:
- R726;R574.61
- Abstract:
- Objective To explore the correlation between serum C-reactive protein (CRP),interleukin-6 (IL-6),procalcitonin (PCT) and acute complex appendicitis in children and examine their diagnostic values.Methods A total of 96 hospitalized children with acute appendicitis underwent operations from 2016 to 2017.They were divided into two groups of simple appendicitis (n=30,A1) and complex suppurative/gangrenous appendicitis (n=60,A2).The preoperative serum concentrations of CRP,IL-6,and PCT were measured and compared for two groups.The receiver operating characteristic (ROC) curves were plotted for analyzing the diagnostic values of CRP,IL-6 and PCT in children with acute complex appendicitis.Results No statistical significance existed in age,gender or weight between two groups (P>0.05).The levels of CRP,IL-6 and PCT were significantly higher in group A2 than those in group A1 (P<0.05).ROC curve was plotted according to the postoperative pathological results for analyzing the diagnostic efficiency of CRP,PCT and IL-6 for complicated appendicitis.AUC of CRP,PCT,IL-6 and their combined test were 0.906(95%CI:0.829-0.956),0.953(95%CI:0.889-0.986),0.765(95%CI:0.668-0.846) and 0.973(95%CI:0.971-0.995) respectively.Value of AUC was PCT+CRP+IL-6 > PCT > CRP > IL-6.AUC of combined test was statistically different from that of CRP/IL-6 (Z=2.932,P=0.003;Z=3.854,P=0.0001).No statistical difference existed between AUC of combined test and that of PCT (Z=1.861,P=0.063) or between AUC of CRP and that of PCT (Z=1.668,P=0.095);and statistical difference existed between AUC of IL-6 and that of CRP/PCT (Z=2.312,P=0.021;Z=3.371,P=0.001).The obtained optimal critical points were 11.47(95%CI:11.42-14.48) mg/L,0.87(95%CI:0.63-0.98) ng/L and 88.60(95%CI:87.12-170.83) pg/ml respectively.Conclusion Clinicians can judge the severity of appendicitis during an early stage by CRP,IL-6 and PCT so as to win the cooperation of parents,perform operations as early as possible and reduce the occurrence of complications.
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Memo
收稿日期:2019-03-18。
基金项目:包头市社会发展科技支撑项目（编号：2017S2001-6-1）
通讯作者:赵永祥,Email:121418388@qq.com;姜海山,Email:584955375@qq.com