Zhao Ding,Zhu Guanghui.Current status and practical considerations in the treatment of congenital pseudarthrosis of the tibia in children[J].Journal of Clinical Pediatric Surgery,,():801-805.[doi:10.3760/cma.j.cn101785-202501062]
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Current status and practical considerations in the treatment of congenital pseudarthrosis of the tibia in children

Journal of Clinical Pediatric Surgery[ISSN:1671-6353/CN:43-1380/R] volume: Number: 2026 09 Page: 801-805 Column: 述评 Date of publication: 2026-09-22
Author(s):
Zhao Ding;  Zhu Guanghui
School of Pediatrics, South China University, Department of Osteology, Hunan Provincial Key Laboratory of Pediatric Bone Science, Hunan Children’s Hospital, Affiliated Children’s Hospital of Xiangya Medical College, Central South University, Changsha 410007, China
Keywords:
Congenital Pseudarthrosis of the Tibia; Surgical Treatment; Drug Therapy
DOI:
10.3760/cma.j.cn101785-202501062
Abstract:
As one of the most challenging rare diseases in pediatric orthopedics,congenital pseudarthrosis of the tibia (CPT) is characterized by segmental tibial dysplasia,a failure of normal bone formation and pseudarthrosis.It is frequently accompanied by angulation deformity,pathological fracture and lower limb length discrepancy.Surgery remains a primary treatment modality.However,its overall prognosis is still disappointing,with high refracture rates and long term complications.In recent years,biological adjuvants such as bisphosphonates and bone morphogenetic proteins,along with innovative cross union strategies and the Masquelet technique,have provided new possibilities for improving clinical outcomes.However,the efficacy and indications of these approaches remain controversial.This review focused on hot topics in CPT management,including understanding of pathogenesis,surgical approach selection,complication management and comprehensive care,aiming to provide insights for clinical decision making and future research.

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Memo

收稿日期:2025-1-22。
基金项目:儿童骨科学湖南省重点实验室专项经费（2023TP1019）；国家重点研发计划-骨科难治性疾病诊疗新模式建立、评价及推广应用（2023YFC2507605）
通讯作者:朱光辉,Email:zgh5650@163.com

Last Update: 1900-01-01