Lu Zhengchen,Zhang Ruyi,Tang Weibing.Progress on the pathogenic mechanisms,diagnostic and therapeutic strategies,and prognosis of human cytomegalovirus-related biliary atresia[J].Journal of Clinical Pediatric Surgery,,():679-683.[doi:10.3760/cma.j.cn101785-202504019]
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Progress on the pathogenic mechanisms,diagnostic and therapeutic strategies,and prognosis of human cytomegalovirus-related biliary atresia

References:

[1] Chung PHY,Zheng S,Tam PKH.Biliary atresia:east versus west[J].Semin Pediatr Surg,2020,29(4):150950.DOI:10.1016/j.sempedsurg.2020.150950.
[2] Tam PKH,Wells RG,Tang CSM,et al.Biliary atresia[J].Nat Rev Dis Primers,2024,10(1):47.DOI:10.1038/s41572-024-00533-x.
[3] Mohamed SOO,Elhassan ABE,Elkhidir IHE,et al.Detection of cytomegalovirus infection in infants with biliary atresia:a meta-analysis[J].Avicenna J Med,2022,12(1):3-9.DOI:10.1055/s-0041-1739236.
[4] Zhao YL,Xu XD,Liu GX,et al.Prognosis of biliary atresia associated with cytomegalovirus:a meta-analysis[J].Front Pediatr,2021,9:710450.DOI:10.3389/fped.2021.710450.
[5] Davenport M.Biliary atresia:clinical aspects[J].Semin Pediatr Surg,2012,21(3):175-184.DOI:10.1053/j.sempedsurg.2012.05.010.
[6] Onpoaree N,Sanpavat A,Sintusek P.Cytomegalovirus infection in liver-transplanted children[J].World J Hepatol,2022,14(2):338-353.DOI:10.4254/wjh.v14.i2.338.
[7] Schattner A.The wide spectrum of presentations of cytomegalovirus infection in immunocompetent hosts:an exhaustive narrative review[J].Pathogens,2024,13(8):667.DOI:10.3390/pathogens13080667.
[8] Adamson CS,Nevels MM.Bright and early:inhibiting human cytomegalovirus by targeting major immediate-early gene expression or protein function[J].Viruses,2020,12(1):110.DOI:10.3390/v12010110.
[9] Lawrence SM,Goshia T,Sinha M,et al.Decoding human cytomegalovirus for the development of innovative diagnostics to detect congenital infection[J].Pediatr Res,2024,95(2):532-542.DOI:10.1038/s41390-023-02957-9.
[10] Pinninti S,Boppana S.Congenital cytomegalovirus infection diagnostics and management[J].Curr Opin Infect Dis,2022,35(5):436-441.DOI:10.1097/qco.0000000000000874.
[11] Nicloux M,Peterman L,Parodi M,et al.Outcome and management of newborns with congenital cytomegalovirus infection[J].Arch Pediatr,2020,27(3):160-165.DOI:10.1016/j.arcped.2020.01.006.
[12] Schildermans J,De Vlieger G.Cytomegalovirus:a troll in the ICU? Overview of the literature and perspectives for the future[J].Front Med (Lausanne),2020,7:188.DOI:10.3389/fmed.2020.00188.
[13] 中国医师协会新生儿科医师分会,中国医师协会新生儿科医师分会感染专业委员会,中华新生儿科杂志编辑委员会.新生儿巨细胞病毒感染管理专家共识[J].中华新生儿科杂志,2021,36(6):1-7.DOI:10.3760/cma.j.issn.2096-2932.2021.06.001. Neonatology Branch of Chinese Medical Association,Committee on Infectious,Diseases of Neonatology Branch of Chinese Medical Doctor Association,Editorial Board of Chinese Journal of Neonatology.Consensus on the management of neonatal cytomegalovirus infection[J].Chin J Neonatol,2021,36(6):1-7.DOI:10.3760/cma.j.issn.2096-2932.2021.06.001.
[14] Ito H.Cytomegalovirus seropositivity is independently associated with cardiovascular disease in non-dialysis-dependent chronic kidney disease[J].QJM,2020,113(9):701.DOI:10.1093/qjmed/hcaa194.
[15] Tsui E,Gonzales JA,Shantha JG,et al.Letermovir for the management of cytomegalovirus-associated uveitis[J].Ocul Immunol Inflamm,2021,29(1):169-174.DOI:10.1080/09273948.2019.1662062.
[16] Chen YN,Hsu KH,Huang CG,et al.Clinical characteristics of infants with symptomatic congenital and postnatal cytomegalovirus infection-an 11-year multicenter cohort study in Taiwan[J].Children (Basel),2023,11(1):17.DOI:10.3390/children11010017.
[17] Ljungman P,Alain S,Chemaly RF,et al.Recommendations from the 10th European Conference on Infections in Leukaemia for the management of cytomegalovirus in patients after allogeneic haematopoietic cell transplantation and other T-cell-engaging therapies[J].Lancet Infect Dis,2025,25(8):e451-e462.DOI:10.1016/S1473-3099(25)00069-6.
[18] Li XP,Zhong YW,Qiao YB,et al.Advances and challenges in cytomegalovirus detection methods for liver transplant donors[J].Diagnostics (Basel),2023,13(21):3310.DOI:10.3390/diagnostics13213310.
[19] Zhao DY,Gong XH,Li YH,et al.Effects of cytomegalovirus infection on the differential diagnosis between biliary atresia and intrahepatic cholestasis in a Chinese large cohort study[J].Ann Hepatol,2021,23:100286.DOI:10.1016/j.aohep.2020.100286.
[20] Fischler B,Czubkowski P,Dezsofi A,et al.Incidence,impact and treatment of ongoing CMV infection in patients with biliary atresia in four European centres[J].J Clin Med,2022,11(4):945.DOI:10.3390/jcm11040945.
[21] Brindley SM,Lanham AM,Karrer FM,et al.Cytomegalovirus-specific T-cell reactivity in biliary atresia at the time of diagnosis is associated with deficits in regulatory T cells[J].Hepatology,2012,55(4):1130-1138.DOI:10.1002/hep.24807.
[22] Chan ES,Abou Mehrem A,de Koning L,et al.Extrahepatic biliary atresia in a premature neonate with congenital cytomegalovirus infection[J].Pathology,2023,55(4):573-576.DOI:10.1016/j.pathol.2022.10.013.
[23] Dong J,Xie T,Li B,et al.Does cytomegalovirus infection and antiviral therapy affect prognosis of biliary atresia? A real-world retrospective cohort study[J].J Med Virol,2024,96(8):e29842.DOI:10.1002/jmv.29842.
[24] Xu Y,Yu JK,Zhang RZ,et al.The perinatal infection of cytomegalovirus is an important etiology for biliary atresia in China[J].Clin Pediatr (Phila),2012,51(2):109-113.DOI:10.1177/0009922811406264.
[25] Zhan JH,Liu SW,Meng Y,et al.Systematic review of the mechanism and assessment of liver fibrosis in biliary atresia[J].Pediatr Surg Int,2024,40(1):205.DOI:10.1007/s00383-024-05778-x.
[26] Munghate G,Anand S,Bhatnagar V,et al.Impact of cytomegalovirus infection on short-term clinical outcomes and operative histopathology in infants with biliary atresia:a single-center prospective cohort study[J].J Indian Assoc Pediatr Surg,2022,27(4):441-447.DOI:10.4103/jiaps.jiaps_138_21.
[27] Su L,Chen Y,Fu M,et al.CD14 facilitates perinatal human cytomegalovirus infection in biliary epithelial cells via CD55[J].JHEP Rep,2024,6(5):101018.DOI:10.1016/j.jhepr.2024.101018.
[28] Yin M,Chen AP,Zhao F,et al.Detection of human cytomegalovirus in patients with epithelial ovarian cancer and its impacts on survival[J].Infect Agent Cancer,2020,15:23.DOI:10.1186/s13027-020-00289-5.
[29] Martelius T,Krogerus L,H?ckerstedt K,et al.Cytomegalovirus infection is associated with increased inflammation and severe bile duct damage in rat liver allografts[J].Hepatology,1998,27(4):996-1002.DOI:10.1002/hep.510270415.
[30] Feldman AG,Mack CL.Biliary atresia:cellular dynamics and immune dysregulation[J].Semin Pediatr Surg,2012,21(3):192-200.DOI:10.1053/j.sempedsurg.2012.05.003.
[31] Wen J,Xiao YT,Wang J,et al.Low doses of CMV induce autoimmune-mediated and inflammatory responses in bile duct epithelia of regulatory T cell-depleted neonatal mice[J].Lab Invest,2015,95(2):180-192.DOI:10.1038/labinvest.2014.148.
[32] Crawford LB,Tempel R,Streblow DN,et al.Human cytomegalovirus induces cellular and humoral virus-specific immune responses in humanized BLT mice[J].Sci Rep,2017,7(1):937.DOI:10.1038/s41598-017-01051-5.
[33] Fu M,Tan LD,Lin ZF,et al.Down-regulation of STAT3 enhanced chemokine expression and neutrophil recruitment in biliary atresia[J].Clin Sci (Lond),2021,135(7):865-884.DOI:10.1042/cs20201366.
[34] Mizukawa Y,Kimishima M,Aoyama Y,et al.Predictive biomarkers for cytomegalovirus reactivation before and after immunosuppressive therapy:a single-institution retrospective long-term analysis of patients with drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic syndrome (DRESS)[J].Int J Infect Dis,2020,100:239-246.DOI:10.1016/j.ijid.2020.08.078.
[35] Mohanty SK,Donnelly B,Lobeck I,et al.The SRL peptide of rhesus rotavirus VP4 protein governs cholangiocyte infection and the murine model of biliary atresia[J].Hepatology,2017,65(4):1278-1292.DOI:10.1002/hep.28947.
[36] Zagory JA,Fenlon M,Dietz W,et al.Prominin-1 promotes biliary fibrosis associated with biliary atresia[J].Hepatology,2019,69(6):2586-2597.DOI:10.1002/hep.30550.
[37] Sergi CM,Gilmour S.Biliary atresia:a complex hepatobiliary disease with variable gene involvement,diagnostic procedures,and prognosis[J].Diagnostics (Basel),2022,12(2):330.DOI:10.3390/diagnostics12020330.
[38] Liliemark U,Svensson JF,Fischler B.Incidence and antiviral treatment of cytomegalovirus infection in infants with biliary atresia[J].Pediatr Surg Int,2023,39(1):117.DOI:10.1007/s00383-023-05394-1.
[39] Mathur P,Udawat P,Mathur P,et al.Antiviral therapy in cytomegalovirus-associated biliary atresia[J].Indian J Pediatr,2022,89(7):732.DOI:10.1007/s12098-022-04093-4.
[40] Parolini F,Hadzic N,Davenport M.Adjuvant therapy of cytomegalovirus IgM+ve associated biliary atresia:prima facie evidence of effect[J].J Pediatr Surg,2019,54(9):1941-1945.DOI:10.1016/j.jpedsurg.2018.12.014.
[41] Lu XX,Jiang JY,Shen Z,et al.Effect of adjuvant steroid therapy in type 3 biliary atresia:a single-center,open-label,randomized controlled trial[J].Ann Surg,2023,277(6):e1200-e1207.DOI:10.1097/sla.0000000000005407.
[42] Zani A,Quaglia A,Hadzi[KG-0.98mm]c[DD(-1]' N,et al.Cytomegalovirus-associated biliary atresia:an aetiological and prognostic subgroup[J].J Pediatr Surg,2015,50(10):1739-1745.DOI:10.1016/j.jpedsurg.2015.03.001.
[43] Yim SH,Choi MC,Kim DG,et al.Risk factors for cytomegalovirus infection and its impact on survival after living donor liver transplantation in South Korea:a nested case-control study[J].Pathogens,2023,12(4):521.DOI:10.3390/pathogens12040521.
[44] Fischler B,Svensson JF,Nemeth A.Early cytomegalovirus infection and the long-term outcome of biliary atresia[J].Acta Paediatr,2009,98(10):1600-1602.DOI:10.1111/j.1651-2227.2009.01416.x.
[45] Kemme S,Canniff JD,Feldman AG,et al.Cytomegalovirus in biliary atresia is associated with increased pretransplant death,but not decreased native liver survival[J].Hepatol Commun,2023,7(8):e0175.DOI:10.1097/HC9.0000000000000175.
[46] 郑露露,吴一波,吴伟,等.Ⅲ型胆道闭锁Kasai手术后患儿自体肝中长期生存情况的影响因素分析[J].临床小儿外科杂志,2023,22(11):1045-1049.DOI:10.3760/cma.j.cn101785-202203017-008. Zheng LL,Wu YB,Wu W,et al.Middle/long-term prognosis and influencing factors of Kasai portoenterostomy on type Ⅲ biliary atresia[J].J Clin Ped Sur,2023,22(11):1045-1049.DOI:10.3760/cma.j.cn101785-202203017-008.

Memo

收稿日期:2025-4-7。
基金项目:国家自然科学基金(82370523)
通讯作者:唐维兵,Email:twbcn@163.com

Last Update: 1900-01-01