Yao Taoyue,Hu Yuan,Chen Wenjuan,et al.Clinical value of right ventricle free wall longitudinal strain plus red blood cell distribution width in pediatric congenital heart disease associated pulmonary arterial hypertension[J].Journal of Clinical Pediatric Surgery,,():642-646.[doi:10.3760/cma.j.cn101785-202506034]
Clinical value of right ventricle free wall longitudinal strain plus red blood cell distribution width in pediatric congenital heart disease associated pulmonary arterial hypertension
- Abstract:
- Objective To explore the clinical value of right ventricular free wall longitudinal strain (RVFWLS) plus red blood cell distribution width (RDW) in pediatric congenital heart disease-related pulmonary arterial hypertension (CHD-PAH). Methods This study retrospectively analyzed the clinical data of 96 children diagnosed with CHD-PAH at Hunan Children’s Hospital from January 2020 to August 2024. Based upon whether or not major adverse events such as all-cause death,heart lung transplantation,and pulmonary arterial hypertension (PAH) deterioration occurred during follow-ups,they were assigned into two groups of adverse event (n=31) and no adverse event (n=65).The differences in laboratory and ultrasonic parameters between two groups were compared.The predictive power of significant indicators was evaluated by constructing receiver operating characteristic (ROC) curve.Independent factors influencing adverse events were identified by multiple Logistic regression analysis.Results Adverse event group showed significant elevations in RDW,N-terminal pro brain natriuretic peptide (NT proBNP) and pulmonary artery systolic pressure (PASP) (P<0.05) while tricuspid annular lateral wall systolic displacement (TAPSE),right ventricular fractional area change (RVFAC) and RVFWLS declined significantly (P<0.05).Multivariate regression analysis revealed that RDW (OR=1.472,95%CI:1.017~2.021,P=0.017) and RVFWLS (OR=0.678,95%CI:0.515~0.892,P=0.005) were independent predictors of adverse events.ROC curve analysis revealed that the area under the curve (AUC) of RVFWLS plus RDW (AUC=0.896) was better than that of a single indicator (RVFWLS AUC=0.833,RDW AUC=0.715).Conclusion The combination of RVFWLS and RDW may improve the predictive efficiency of adverse events in pediatric CHD-PAH.It provides reliable non-invasive references for clinical prognostic evaluations.
References:
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Memo
收稿日期:2025-6-15。
基金项目:湖南省卫生健康委员会项目(202109021301)
通讯作者:刘金桥,Email:826423695@qq.com