Liu Denghui,Li Yong,Li Ming,et al.Clinical diagnosis and treatment of children with extracranial mixed germ cell tumors:a report of 13 cases[J].Journal of Clinical Pediatric Surgery,,():467-471.[doi:10.3760/cma.j.cn101785-202504014]
Clinical diagnosis and treatment of children with extracranial mixed germ cell tumors:a report of 13 cases
- Keywords:
- Neoplasms; Germ Cell and Embryonal; Diagnosis; Treatment; Prognosis; Surgical Procedures; Operative; Child
- Abstract:
- Objective Toexplore the clinical characteristics,diagnoses,treatments and prognoses of extracranial mixed germ cell tumor (MGCT) in children.Methods A retrospective analysis was performed on the clinical and follow-up data of 13 children with extracranial mixed germ cell tumors (MGCT) admitted to Affiliated Children’s Hospital,Xiangya School of Medicine,Central South University(Hunan Children’s Hospital),from January to June 2023.The clinical characteristics,diagnoses,treatments and prognoses of extracranial MGCT children were summarized.Results Among them,there were 5 boys and 8 girls with a median onset age of 10 year (4 day to 153 month).Primary tumors were located at gonad (n=7)(2 cases in testis,5 cases in ovary) and extra gonadal sites (n=6)(3 cases in mediastinum,2 in retroperitoneum,1 in sacrococcygeal region).According to the criteria of Children’s Oncology Group (COG),the clinical stages were Ⅰ (n=3),Ⅱ (n=2),Ⅲ (n=3) and Ⅳ (n=5).Additionally,according to the risk classification of Malignant Germ Cell International Alliance (MaGIC),the clinical risks were low (n=4),moderate (n=3) and high (n=6).Upon an initial diagnosis,all serum levels of alpha fetoprotein (AFP) were elevated while β-human chorionic gonadotropin (β-HCG) rose (n=7).All of them underwent surgery plus chemotherapy.The outcomes were complete remission (n=12) and recurrence (n=1).There was no death.The follow-up cutoff was June 2024 with a median follow-up of 33 month.Conclusion Extracranial MGCT diagnosis is dependent upon imaging and tumor markers (AFP/β-HCG).Surgical resection plus chemoradiotherapy may achieve a favorable prognosis.
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Memo
收稿日期:2025-4-5。
基金项目:湖南省儿童实体瘤临床医学研究中心项目(2023SK4058)
通讯作者:李勇,Email:liyongpuwaike@163.com