Huang Shaogang,Xu Rui,Zeng Yefeng,et al.Research advances in urethral tissue injuries and functional changes in children with congenital urinary tract obstruction[J].Journal of Clinical Pediatric Surgery,2025,(02):196-200.[doi:10.3760/cma.j.cn101785-202401059-017]
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Research advances in urethral tissue injuries and functional changes in children with congenital urinary tract obstruction

References:

[1] Chevalier RL.Congenital urinary tract obstruction:the long view[J].Adv Chronic Kidney Dis,2015,22(4):312-319.DOI:10.1053/j.ackd.2015.01.012.
[2] Klein J,Gonzalez J,Miravete M,et al.Congenital ureteropelvic junction obstruction:human disease and animal models[J].Int J Exp Pathol,2011,92(3):168-192.DOI:10.1111/j.1365-2613.2010.00727.x.
[3] Tangirala S,Bhaskaranand N,Kini PG,et al.Clinical profile and outcome of children with congenital obstructive uropathy[J].Indian J Pediatr,2019,86(4):354-359.DOI:10.1007/s12098-019-02876-w.
[4] McLeod DJ,Ching CB,Sebasti?o YV,et al.Common clinical markers predict end-stage renal disease in children with obstructive uropathy[J].Pediatr Nephrol,2019,34(3):443-448.DOI:10.1007/s00467-018-4107-z.
[5] Chang CP,McDill BW,Neilson JR,et al.Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machinery[J].J Clin Invest,2004,113(7):1051-1058.DOI:10.1172/JCI20049.
[6] G?rmü? U,Kasap M,Akp?nar G,et al.Comparative proteome analyses of ureteropelvic junction obstruction and surrounding ureteral tissue[J].Cells Tissues Organs,2020,209(1):2-12.DOI:10.1159/000506736.
[7] Samaranayake UMJE,Mathangasinghe Y,Liyanage UA,et al.Vari-ations in the density and distribution of cajal like cells associated with the pathogenesis of ureteropelvic junction obstruction:a systematic review and meta-analysis[J].Front Surg,2021,8:721143.DOI:10.3389/fsurg.2021.721143.
[8] Kajbafzadeh AM,Payabvash S,Salmasi AH,et al.Smooth muscle cell apoptosis and defective neural development in congenital ureteropelvic junction obstruction[J].J Urol,2006,176(2):718-723.DOI:10.1016/j.juro.2006.03.041.
[9] Babu R,Vittalraj P,Sundaram S,et al.Pathological changes in ureterovesical and ureteropelvic junction obstruction explained by fetal ureter histology[J].J Pediatr Urol,2019,15(3):240.e1-240.e7.DOI:10.1016/j.jpurol.2019.02.001.
[10] Gimpel C,Masioniene L,Djakovic N,et al.Complications and long-term outcome of primary obstructive megaureter in childhood[J].Pediatr Nephrol,2010,25(9):1679-1686.DOI:10.1007/s00467-010-1523-0.
[11] Reicherz A,Eltit F,Almutairi K,et al.Ureteral obstruction promotes ureteral inflammation and fibrosis[J].Eur Urol Focus,2023,9(2):371-380.DOI:10.1016/j.euf.2022.09.014.
[12] V?rel? S,Omling E,B?rjesson A,et al.Resolution of hydronephrosis after pyeloplasty in children[J].J Pediatr Urol,2021,17(1):102.e1-102.e7.DOI:10.1016/j.jpurol.2020.10.031.
[13] Wickramasekara N,Ignatius J,Lamahewage A.Sonographic follow-up after pyeloplasty:a large,retrospective cohort analysis[J].Pediatr Surg Int,2023,39(1):132.DOI:10.1007/s00383-023-05422-0.
[14] He Y,Wu XM,Xu YR,et al.Ureteral dilation recovery after intravesical reimplantation in children with primary obstructive megaureter[J].Front Pediatr,2023,11:1164474.DOI:10.3389/fped.2023.1164474.
[15] Chuang YH,Chuang WL,Huang SP,et al.Atorvastatin ameliorates tissue damage of obstructed ureter in rats[J].Life Sci,2011,89(21/22):795-805.DOI:10.1016/j.lfs.2011.09.010.
[16] Chuang YH,Chuang WL,Huang SP,et al.Cyclooxygenase-2 inhibitor ameliorates ureteric damage in rats with obstructed uropathy[J].Eur J Pharmacol,2007,569(1/2):126-137.DOI:10.1016/j.ejphar.2007.04.046.
[17] Kart Y,Karaku? OZ,Ate? O,et al.Altered expression of interstitial cells of Cajal in primary obstructive megaureter[J].J Pediatr Urol,2013,9(6 Pt B):1028-1031.DOI:10.1016/j.jpurol.2013.02.003.
[18] Yiee JH,Johnson-Welch S,Baker LA,et al.Histologic differences between extrinsic and intrinsic ureteropelvic junction obstruction[J].Urology,2010,76(1):181-184.DOI:10.1016/j.urology.2010.02.007.
[19] Roshani H,Weltings S,Dabhoiwala NF,et al.Pharmacological modulation of ureteric peristalsis in a chronically instrumented conscious pig model:effect of adrenergic and nitrergic modulation[J].World J Urol,2016,34(5):747-754.DOI:10.1007/s00345-015-1663-8.
[20] Alberti C.Congenital ureteropelvic junction obstruction:physiopathology,decoupling of tout court pelvic dilatation-obstruction semantic connection,biomarkers to predict renal damage evolution[J].Eur Rev Med Pharmacol Sci,2012,16(2):213-219.
[21] Zhang PL,Peters CA,Rosen S.Ureteropelvic junction obstruction:morphological and clinical studies[J].Pediatr Nephrol,2000,14(8/9):820-826.DOI:10.1007/s004679900240.
[22] Azili MN,Güney D,Ka?ar A,et al.Is there an association between histopathological changes in the lower ureter and renal functions? Evaluation of patients who underwent ureteroneocystostomy for ureterovesical obstruction or vesicoureteral reflux[J].Turk J Med Sci,2015,45(1):225-228.
[23] Hashitani H,Nguyen MJ,Noda H,et al.Interstitial cell modulation of pyeloureteric peristalsis in the mouse renal pelvis examined using FIBSEM tomography and calcium indicators[J].Pflugers Arch,2017,469(5/6):797-813.DOI:10.1007/s00424-016-1930-6.
[24] Hunziker M,O’Donnell AM,Gosemann J,et al.Altered anoctamin-1 and tyrosine phosphorylation in congenital ureteropelvic junction obstruction[J].J Pediatr Surg,2020,55(8):1621-1625.DOI:10.1016/j.jpedsurg.2020.02.001.
[25] Burdyga T,Lang RJ.Excitation-contraction coupling in ureteric smooth muscle:mechanisms driving ureteric peristalsis[J].Adv Exp Med Biol,2019,1124:103-119.DOI:10.1007/978-981-13-5895-1_4.
[26] Lang RJ,Hashitani H.Pacemaker mechanisms driving pyeloureteric peristalsis:modulatory role of interstitial cells[J].Adv Exp Med Biol,2019,1124:77-101.DOI:10.1007/978-981-13-5895-1_3.
[27] Hashitani H,Lang RJ,Mitsui R,et al.Distinct effects of CGRP on typical and atypical smooth muscle cells involved in generating spontaneous contractions in the mouse renal pelvis[J].Br J Pharmacol,2009,158(8):2030-2045.DOI:10.1111/j.1476-5381.2009.00514.x.
[28] Kol?da P,Pilecki W.Nature of interstitial cells of Cajal of the upper urinary tract[J].Adv Clin Exp Med,2014,23(4):627-632.DOI:10.17219/acem/37245.
[29] Wishahi M,Mehena AA,Elganzoury H,et al.Telocyte and Cajal cell distribution in renal pelvis,ureteropelvic junction (UPJ),and proximal ureter in normal upper urinary tract and UPJ obstruction:reappraisal of the aetiology of UPJ obstruction[J].Folia Morphol (Warsz),2021,80(4):850-856.DOI:10.5603/FM.a2020.0119.
[30] Wishahi M,Hafiz E,Wishahy AMK,et al.Telocytes,c-Kit positive cells,smooth muscles,and collagen in the ureter of pediatric patients with congenital primary obstructive megaureter:elucidation of etiopathology[J].Ultrastruct Pathol,2021,45(3):257-265.DOI:10.1080/01913123.2021.1954734.
[31] Cancian M,Pareek G,Caldamone A,et al.Histopathology in ureteropelvic junction obstruction with and without crossing vessels[J].Urology,2017,107:209-213.DOI:10.1016/j.urology.2017.05.013.
[32] Babu R,Vittalraj P,Sundaram S,et al.Comparison of different pathological markers in predicting pyeloplasty outcomes in children[J].J Pediatr Surg,2020,55(8):1616-1620.DOI:10.1016/j.jpedsurg.2019.08.015.
[33] Pintér AB,Horváth A,Hrabovszky Z.The relationship of smooth muscle damage to age,severity of pre-operative hydronephrosis and post-operative outcome in obstructive uropathies[J].Br J Urol,1997,80(2):227-233.DOI:10.1046/j.1464-410x.1997.00311.x.
[34] Abbas NAT,El Salem A,Awad MM.Empagliflozin,SGLT2 inhibitor,attenuates renal fibrosis in rats exposed to unilateral ureteric obstruction:potential role of klotho expression[J].Naunyn Schmiedebergs Arch Pharmacol,2018,391(12):1347-1360.DOI:10.1007/s00210-018-1544-y.
[35] Hosseinian S,Rad AK,Bideskan AE,et al.Thymoquinone ameliorates renal damage in unilateral ureteral obstruction in rats[J].Pharmacol Rep,2017,69(4):648-657.DOI:10.1016/j.pharep.2017.03.002.
[36] Meng XM,Nikolic-Paterson DJ,Lan HY.TGF-β:the master regulator of fibrosis[J].Nat Rev Nephrol,2016,12(6):325-338.DOI:10.1038/nrneph.2016.48.
[37] Tokhmafshan F,Brophy PD,Gbadegesin RA,et al.Vesicoureteral reflux and the extracellular matrix connection[J].Pediatr Nephrol,2017,32(4):565-576.DOI:10.1007/s00467-016-3386-5.
[38] Medel RJr,Quesada EM.Ultrastructural characteristics of collagen tissue in normal and congenitally dilated ureter[J].Eur Urol,1985,11(5):324-329.DOI:10.1159/000472529.
[39] Lee BR,Silver RI,Partin AW,et al.A quantitative histologic analysis of collagen subtypes:the primary obstructed and refluxing megaureter of childhood[J].Urology,1998,51(5):820-823.DOI:10.1016/s0090-4295(98)00013-2.
[40] Haralambous-Gasser A,Chan D,Walker RG,et al.Collagen studies in newborn rat kidneys with incomplete ureteric obstruction[J].Kidney Int,1993,44(3):593-605.DOI:10.1038/ki.1993.286.
[41] Park E,Cox M,Scotland K,et al.Erythropoietin promotes functional recovery via anti-apoptotic mechanisms in mouse unilateral ureteral obstruction[J].Cell Stress Chaperones,2020,25(2):245-251.DOI:10.1007/s12192-020-01067-3.
[42] Koleda P,Apoznanski W,Wozniak Z,et al.Changes in interstitial cell of Cajal-like cells density in congenital ureteropelvic junction obstruction[J].Int Urol Nephrol,2012,44(1):7-12.DOI:10.1007/s11255-011-9970-5.
[43] Apoznanski W,Koleda P,Wozniak Z,et al.The distribution of interstitial cells of Cajal in congenital ureteropelvic junction obstruction[J].Int Urol Nephrol,2013,45(3):607-612.DOI:10.1007/s11255-013-0454-7.
[44] Hammad FT,Lammers WJ,Stephen B,et al.Propagation characteristics of the electrical impulse in the normal and obstructed ureter as determined at high electrophysiological resolution[J].BJU Int,2011,108(2 Pt 2):E36-E42.DOI:10.1111/j.1464-410X.2011.10378.x.

Memo

收稿日期:2024-1-26。
基金项目:深圳市医学重点学科小儿外科重点专科项目(2020—2024)(SZXK035);广东省高水平医院建设专项资助项目
通讯作者:李守林,Email:lishoulinsz@126.com

Last Update: 2025-02-28