Yao Yiyi,Zhu Yi,Chen Zheng,et al.Median effective dose of esketamine for preventing pain caused by an injection of propofol medium-chain triglyceride/long-chain triglyceride emulsion in school-age children[J].Journal of Clinical Pediatric Surgery,,():965-969.[doi:10.3760/cma.j.cn101785-202311038-012]
Median effective dose of esketamine for preventing pain caused by an injection of propofol medium-chain triglyceride/long-chain triglyceride emulsion in school-age children
- Keywords:
- Esketamine; Propofol Medium-Chain Triglyceride/Long-Chain Triglyceride Emulsion; Injection Pain; ED50; Surgical Procedures; Operative; Child
- Abstract:
- Objective To explore the half effective dose of esketamine in mitigating pain of propofol medium-chain triglyceride/long-chain triglyceride (MCT/LCT) emulsion injection in school-age children. Methods From May 2023 to July 2023, 26 school-age children aged 6-13 year with ASA grade I-II underwent operations under general anesthesia.Anesthesia was performed by two anesthesiologists.The first anesthesiologist injected esketamine before propofol MCT/LCT emulsion.At the same time, adverse reactions were recorded by another anesthesiologist not knowing the dosage of drug.Pain after an injection of propofol MCT/LCT emulsion was evaluated by Ambesh score.The dose of esketamine was adjusted according to the modified sequential method.The initial dose of esketamine was 0.2 mg/kg.If Ambesh score ≤1, effective group (n=14) was designated.The dose of esketamine in the next case dropped by 0.02 mg/kg.Conversely, if Ambesh score ＞1, ineffective group (n=12) was selected and the dose of esketamine in the next case was boosted by 0.02 mg/kg accordingly.Trial was terminated when there were seven intersections (effective to ineffective).ED50, ED95 and ED99 effects of esketamine on propofol MCT/LCT emulsion injection pain were calculated by Probit regression analysis. Results ED50 of esketamine in reducing propofol MCT/LCT emulsion injection pain in school-age children was 0.14 mg/kg (95%CI:0.07-0.18 mg/kg).ED95 was 0.22 mg/kg (95%CI:0.18-0.90 mg/kg) and ED99 0.25 mg/kg (95%CI:0.2-1.2 mg/kg). Conclusions ED50 of esketamine is 0.14 mg/kg in reducing propofol MCT/LCT emulsion injection pain in school-age children.
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Memo
收稿日期:2023-11-26。
基金项目:湖南省自然科学基金(2019JJ50294)
通讯作者:杜真,Email:meggyzhen@163.com