Qin Shanlu,Dong Kuiran.Research advances in embryological origin of Wilms tumor[J].Journal of Clinical Pediatric Surgery,,():697-700.[doi:10.3760/cma.j.cn101785-202207041-018]
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Research advances in embryological origin of Wilms tumor

Journal of Clinical Pediatric Surgery[ISSN:1671-6353/CN:43-1380/R] volume: Number: 2024 07 Page: 697-700 Column: 综述 Date of publication: 2024-07-01
Author(s):
Qin Shanlu;  Dong Kuiran
National Children’s Medical Center, Department of Oncological Surgery, Children’s Hospital of Fudan University, Shanghai Key Laboratory of Birth Defects, Shanghai 201100, China
Keywords:
Wilms Tumor; Non-coding RNA; Methylation; Surgical Procedures;  Operative; Child
DOI:
10.3760/cma.j.cn101785-202207041-018
Abstract:
Characterized by multiple congenital anomalies,nephroblastoma (Wilms tumor,WT) is the most common renal malignancy in children.Embryonic kidney has at least three lineage-specific progenitor cells.Usually lost before birth,these cells with nephrogenic residue persist in WT.Therefore WT is an embryonic tumor reproducing the histological growth pattern of kidney.As one kind of tumor cells with high differentiation potential,tumor stem cells are also closely correlated with the occurrence and development of WT.Thanks to mainstay surgery plus chemotherapy,5-year survival rate of early stage WT has surpassed 90%.However,some patients still die from tumor metastasis and recurrence.Therefore a thorough understanding the formation and regulation of developing kidney and in-depth exploring the origin of embryonic precursors of WT may provide novel therapeutic strategies for managing WT.

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Memo

收稿日期:2022-7-24。
基金项目:唐仲英基金会项目(ZSBK0070)
通讯作者:董岿然,Email:kuiran@fudan.edu.cn

Last Update: 1900-01-01