Zhao Zhenhui,Xiong Zhu,Zeng Shuaidan,et al.Research progress on the genetics and molecular regulatory mechanisms of developmental hip dysplasia[J].Journal of Clinical Pediatric Surgery,,22():1095-1100.[doi:10.3760/cma.j.cn101785-202210022-019]
Research progress on the genetics and molecular regulatory mechanisms of developmental hip dysplasia
- Keywords:
- Developmental Dysplasia of the Hip; Genetics; Pathogenesis
- Abstract:
- Developmental dysplasia of the hip (DDH) is one of the common musculoskeletal malformations in pediatric orthopedics.Its abnormalities mainly include instability,subluxation and even a complete dislocation of hip joint.Mild dysplasia may disappear by itself.However,other hip deformities misdiagnosed and improperly treated during an early stage worsen progressively,leading to hip pain,limited movement,abnormal gait and ultimately adult degenerative arthritis.DDH may be caused by congenital predisposing and acquired environmental factors.However,its exact genetic model,pathogenesis and specific molecular regulation mechanism in the occurrence and development of DDH have remained elusive.Only through clarifying the specific pathogenesis of DDH disease,clinicians gain a deeper understanding of the disease to achieve its early diagnosis and timely treatment for better outcomes.This review summarized the latest genetic researches of DDH and the molecular regulatory mechanism related to its pathogenesis.
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Memo
收稿日期:2022-10-14。
基金项目:广东省高水平医院建设专项经费资助(ynkt2022-zz09)
通讯作者:熊竹,Email:bamboobear@163.com