Ding Zhili,Bao Jingfeng,Sun Hailiang,et al.Diagnostic value of Alvarado score,C-reactive protein,neutrophil lymphocyte ratio in children with perforated appendicitis[J].Journal of Clinical Pediatric Surgery,,22():1060-1064.[doi:10.3760/cma.j.cn101785-202201022-011]
Diagnostic value of Alvarado score,C-reactive protein,neutrophil lymphocyte ratio in children with perforated appendicitis
- Keywords:
- Appendicitis; Diagnosis; C-Reactive Protein; Lymphocytes; Surgical Procedures; Operative; Child
- Abstract:
- Objective To explore the diagnostic value of Alvarado score (AS),C-reactive protein (CRP) and neutrophil lymphocyte ratio (NLR) in children with perforated appendicitis (PA).Methods For this retrospective study,120 children hospitalized with acute appendicitis from September 2018 to September 2020 were selected.According to the pathological results,they were assigned into two groups of perforated (n=60) and non-perforated (n=60).The inter-group differences of gender,age,AS,CRP and NLR were examined.The relevant parameters assisting in the diagnosis of PA were screened by regression analysis.And receiver operating characteristic (ROC) curve was utilized for predicting the diagnostic value of relevant parameters in PA children.Results Logistic regression analysis indicated that AS(OR=2.899,95%CI:1.704~4.930),CRP(OR=1.130,95%CI:1.002~1.025) and NLR(OR=1.130,95%CI:1.040~1.227) were the independent risk factors of PA.The areas under the ROC curve of AS,CRP and NLR were 0.873(95%CI:0.812~0.934),0.765(95%CI:0.683~0.848) and 0.763(95%CI:0.679~0.847); The areas under the ROC curve of AS plus CRP,AS plus NLR and AS plus CRP/NLR were 0.897(95%CI:0.844~0.950),0.904(95%CI:0.852~0.956) and 0.911(95%CI:0.873~0.967).Conclusions AS ＞7.5,CRP＞60.9 ng/mL and NLR＞15.7 offer decent predictive values in the diagnosis of PA in children.It may gauge the severity of appendicitis in an early stage.
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Memo
收稿日期:2022-1-11。
基金项目:常州市卫健委科技项目(WZ202219)
通讯作者:汤强,Email:zchcunt@163.com