Wang Chao,Zhang Jianmin,Wang Fang,et al.Effect of autologous blood transfusion on coagulation functions and prognoses of children after a removal of cerebral hematoma[J].Journal of Clinical Pediatric Surgery,,22():855-860.[doi:10.3760/cma.j.cn101785-202210051-011]
Effect of autologous blood transfusion on coagulation functions and prognoses of children after a removal of cerebral hematoma
- Keywords:
- Children; Cerebral Hematoma; Outcome; Coagulation; Autologous transfusion
- Abstract:
- Objective To explore the effect of autologous blood transfusion on coagulation functions and prognoses in children after a removal of cerebral hematoma.Methods For this retrospective study,132 children undergoing cerebral hematoma removal from February 2016 to April 2022 were selected as study subjects.They were assigned into three groups of A(n=16,autologous blood intra-operation),B(n=88,allogenic blood intra-operation)and C(n=28,both autologous and allogenic blood intra-operation).Coagulation functions and blood routines post-operation were compared among three groups.Hospitalization expense,length of hospitalization stay,postoperative complications and prognoses as valued by Glasgow outcome scale(GOS)were recorded.Results In three groups,partial thrombin activation time was[33.0(29.0,38.6)],[33.2(30.3,37.9)]and[33.8(30.7,44.3)]s;Prothrombin time(13.5±1.2),(13.8±1.5),(14.2±2.2)s;International standardized ratio(1.1±0.1),(1.2±0.1),(1.2±0.1);Postoperative fibrinogen concentration(2.4±0.8),(2.0±0.6),(2.0±0.9)g/L.There were no statistical differences(P>0.05).No postoperative complications were caused by blood transfusion.Postoperative hemoglobin was(111.0±13.4),(112.4±20.0),(121.7±19.9)g/L;Postoperative hematocrit(32.1±3.8)%,(32.2±5.6)%,(34.7±5.4)%.There were no statistical differences(P>0.05).Postoperative platelet of three groups was[265.0(214.5,318.5)]×109,[217.0(165.0,267.5)]×109,[179.5(106.2,237.5)]×109.There were no statistical differences(P<0.05).The count of platelet was significantly lower in group C than that in group A.There was statistical difference(P<0.017).Hospitalization time of three groups was[9(5,14)],[8(5,11)],[12(5,21)]day;Hospitalization expense[57 260(39 165,72 648)],[48 998(38 880,64 447)],[63 130(42 181,83 260)]yuan;Infection complications 4,12,5 cases;Complication of cerebral hernia 0,2,0 case;Complications of epilepsy 1,8,3 cases;Thrombotic complications 0,3,0 case.There were no statistical differences(P>0.05).GOS was 5(n=0),4(n=16),3(n=0),2(n=0),1(n=0)in group A,5(n=1),4(n=66),3(n=9),2(n=12),1(n=1)in group B and 5(n=3),4(n=15),3(n=7),2(n=3),1(n=3)in group C.The differences were statistically significant(P<0.05).GOS of group A was significantly better than that of group C and the difference was statistically significant(P<0.017).No significant changes existed in duration of hospitalization,expense of hospital or rate of complication among three groups(P>0.05).GCS,ASA and GOS grading of group A was significantly better than that(P<0.05).Conclusion Autologous blood transfusion does not impair blood coagulations significantly and the outcome is excellent in children after a removal of cerebral hematoma.
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Memo
收稿日期:2022-10-24。
通讯作者:张建敏,Email:zhangjianmin@bch.com.cn