Wu Xiaoxia,Liu Wenyue,Zhang Hui,et al.Risk factors of poor short-term prognosis in neonatal intestinal atresia children[J].Journal of Clinical Pediatric Surgery,,22():818-821.[doi:10.3760/cma.j.cn101785-202306009-004]
Risk factors of poor short-term prognosis in neonatal intestinal atresia children
- Keywords:
- Intestinal Atresia; Prognosis; Risk Factors; Surgical Procedures; Operative; Child
- Abstract:
- Objective To explore the risk factors of poor short-term prognosis after surgery in neonatal intestinal atresia(NIA)children.Methods From January 2009 to May 2020,the relevant clinical and follow-up data were retrospectively reviewed for 298 NIA children.They were assigned into two groups of survival(n=267)and death(n=31)according to whether or not surviving within 180 days post-operation.The factors associated with the prognosis of NIA were compared between two groups,including birth weight,gestational age,gender,operative age,operative duration,atresia type,atresia location and complex intestinal atresia,postoperative anastomotic leakage,intestinal obstruction,necrotizing enterocolitis(NEC)and short bowel syndrome(SBS).Variables with P＜0.10 in univariate analysis were included for multivariate logistic regression analysis for screening the risk factors for poor short-term prognosis of NIA.Results The curative rate was 89.60%.No significant inter-group differences existed in gender,operative age or operative duration(P>0.05).Significant inter-group differences existed in proportion of complex NIA[70.97%(22/31)vs.32.21%(86/267)],prematurity[54.84%(17/31)vs.27.34%(73/267)],low birth weight[54.84%(17/31)vs.16.48%(44/267)],postoperative necrotizing enterocolitis(NEC)[22.58%(7/31)vs.3.37%(9/267)],anastomotic leakage[19.35%(6/31)vs.1.50%(4/267)]and SBS[25.81%(8/31)vs.7.49%(20/267)](P<0.05).Logistic multivariate regression analysis indicated that postoperative anastomotic leakage(OR=41.682,95%CI:7.537-230.512),NEC(OR=12.325,95%CI:2.857-53.180),low birth weight(OR=6.614,95%CI:2.124-20.601)and complex NIA(OR=5.149,95%CI:1.623-16.337)were risk factors for poor short-term prognosis of NIA.Conclusion Anastomotic leakage,NEC,low birth weight and complex NIA are risk factors for poor short-term prognosis of NIA.
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Memo
收稿日期:2023-6-4。
基金项目:山西省重点研发计划项目(201803D31181);山西省儿童医院课题(2021027);山西省卫生健康委课题(2022074)
通讯作者:任红霞,Email:renhongxia100@sina.com