Ma Xin,Zhou Kai,Liang Yinbo,et al.Meta-analysis of risk factors associated with recurrence of thyroid carcinoma in children and adolescents[J].Journal of Clinical Pediatric Surgery,,22():671-679.[doi:10.3760/cma.j.cn101785-202211043-013]
Meta-analysis of risk factors associated with recurrence of thyroid carcinoma in children and adolescents
- Abstract:
- Objective To explore the risk factors of postoperative recurrence of thyroid carcinoma in children and adolescents (caTC) to identify the high-risk population of postoperative recurrence of caTC early.Methods According to the evidence-based medicine methodology, PubMed, Web of Science, China Wanfang and Chinese Biomedical Literature Database were searched for the risk factors of postoperative recurrence of caTC published since May 2022.According to the inclusion and exclusion criteria, two researchers independently screened the retrieved literatures and extracted the research indicators of age, gender, extraglandular invasion, tumor diameter, surgical approach, cervical lymph node metastasis, bilateral involvement, multifocality & I131 radiotherapy.RevMan 5.3 was utilized for Meta-analysis.Results A total of 7 articles (341 children) were finally retrieved.Meta-analysis indicated that age ≤ 10 year (OR=4.03, 95%CI:1.0-15.63, P=0.04), extraglandular involvement (OR=0.10, 95%CI:0.02-0.43, P=0.002) and multifocality (OR=0.14, 95%CI:0.06-0.32, P<0.001) were risk factors for recurrent caTC.Gender, tumor diameter, bilateral involvement, T stage, cervical lymph node metastasis, surgical approach and I131 therapy had no effect on recurrent caTC.Conclusion Children and adolescents with thyroid carcinoma ≤ 10 years of age, multifocal tumors and extraglandular invasion have a higher risk of postoperative recurrence.
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Memo
收稿日期:2022-11-21。
通讯作者:赵舸,Email:13835103128@qq.com