Li Boya,Li Jiao,Yang Bo,et al.Clinical symptoms and treatment outcomes of children with monosymptomatic nocturnal enuresis having treatment-resistant factors[J].Journal of Clinical Pediatric Surgery,,22():105-111.[doi:10.3760/cma.j.cn101785-202212013-002]
Clinical symptoms and treatment outcomes of children with monosymptomatic nocturnal enuresis having treatment-resistant factors
- Keywords:
- Nocturnal Enuresis; Etiology; Nocturnal Enuresis; Physiopathology; Treatment Outcome; Child
- Abstract:
- Objective To compare the symptoms and treatment outcomes of children with monosymptomatic nocturnal enuresis(MSNE)having treatment-resistant factors [occult spina bifida,attention deficit hyperactivity disorder(ADHD),family history of enuresis,constipation & adenoid/tonsil hypertrophy] with those without treatment-resistant factors.Methods From January 2021 to January 2022,clinical data of MSNE children were retrospectively reviewed,including baseline profiles,symptoms related to treatment-resistance factors,frequency of enuresis,treatment course and treatment outcomes.The relevant clinical data were analyzed by t,χ2 and nonparametric tests according to data type.Results A total of 434 children without treatment-resistant factors(control group)and 76 children with treatment-resistant factors(resistant group)were included,concurrently occult spina bifida(n=21),ADHD(n=18),family history of enuresis(n=15),constipation(n=14)and adenoid/tonsillar hypertrophy(n=8).No significant inter-group difference existed in age or gender.The frequency of nocturnal enuresis was significantly higher in resistant group than that in control group(P<0.001)and multiple treatments were often required(P<0.001).In terms of treatment outcomes,resistant group often required longer treatment course(P<0.001)and cure rate was significantly lower than that in control group(P<0.001).Overall performance and treatment outcome of specific resistant factors(occult spina bifida,ADHD,family history of enuresis,constipation & adenoid/tonsil hypertrophy)were similar.Except for treatment outcome of occult spina bifida group,it failed to show a distinct statistical difference from control group.Conclusion Children with MSNE with treatment-resistant factors are significantly more symptomatic.With a longer treatment course,it has a lower cure rate.
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Memo
收稿日期:2022-12-5。
基金项目:国家自然科学基金资助项目(82101666)
通讯作者:王学军,wangxuejun028@sina.com