Zhu Zhiyun,Wang Huanmin,Wang Jiarong,et al.Initial observations of hyperthermic intraperitoneal chemotherapy for pediatric abdominal cancer[J].Journal of Clinical Pediatric Surgery,,21():1116-1122.[doi:10.3760/cma.j.cn101785-202202024-004]
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Initial observations of hyperthermic intraperitoneal chemotherapy for pediatric abdominal cancer

Journal of Clinical Pediatric Surgery[ISSN:1671-6353/CN:43-1380/R] volume: 第21卷 Number: 2022 12 Page: 1116-1122 Column: 专题·儿童泌尿生殖系肿瘤 Date of publication: 1900-01-01
Author(s):
Zhu Zhiyun1;  Wang Huanmin1;  Wang Jiarong2;  Chang Xiaofeng1;  Qin Hong1;  Yang Wei1;  Cheng Haiyan1;  Meng Deguang2
1 Department of Surgical Oncology, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China;
2 Department of Surgical Oncology, Baoding Branch of Beijing Children’s Hospital, Baoding Children’s Hospital, Baoding 071000, China
Keywords:
Abdominal Neoplasms; Hyperthermic Intraperitoneal Chemotherapy; Surgical Procedures;  Operative; Treatment Outcome; Child
DOI:
10.3760/cma.j.cn101785-202202024-004
Abstract:
Objective To explore the safety,feasibility and short-term outcomes of hyperthermic intraperitoneal chemotherapy (HIPEC) for abdominal cancer in children.Methods From December 2019 to May 2021,16 patients with abdominal malignant tumor underwent surgical resection (cytoreductive surgery or tumorectomy) plus HIPEC.The median age was 68(8-167) months.Clinical characteristics,therapies and short-term outcomes were retrospectively analyzed.Results The histologic types included wilms tumor (n=5),rhabdomyosarcoma (n=4),malignant renal rhabdoid (n=1),undifferentiated sarcoma (n=1),immature teratoma (n=1),neuroblastoma (n=2),serous peritoneal carcinoma (n=1) and malignant ovarian germ cell tumor (n=1).Six cases underwent the initial operation and ten cases were re-operated for tumor recurrences.The median peritoneal carcinomatosis index (PCI) was 2.5(0-21) and the completeness of cytoreduction (CC) score (0-1) post-resection.There was no perioperative mortality or life-threatening complication.Four children had grade 3 adverse events within 30 days after surgery and HIPEC.The median follow-up period was 8(3.3-20) months.After surgery and HIPEC,six cases recurred.Three children died due to recurrence.One case had chemotherapy,surgery and radiotherapy after recurrence and survived without disease while another two cases received chemotherapy after recurrence and survived with disease.The remainders had no evidence of disease.The median disease-free survival (DFS) was 7.4(2-20) months.Conclusion HIPEC is both safe and feasible for pediatric abdominal malignant tumors.There is no onset of serious perioperative complications and adverse events are tolerable.The short-term outcomes are decent while long-term effectiveness requires more cases and extended follow-ups.

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Memo

收稿日期:2022-2-10。
基金项目:中国工程院咨询研究项目(2019-XY -34)
通讯作者:孟德光,Email:m15533222221@163.com

Last Update: 1900-01-01