Tang Ling,Xiao Ting,Du Zhen,et al.Effectiveness and safety evaluations of s-ketamine during laparoscopic high ligation of hernia sac in children[J].Journal of Clinical Pediatric Surgery,,21():758-763.[doi:10.3760/cma.j.cn101785-202110038-010]
Effectiveness and safety evaluations of s-ketamine during laparoscopic high ligation of hernia sac in children
- Keywords:
- Hernia; Inguinal/SU; Anesthesia/MT; Anesthetics/AD; Treatment Outcome; Anesthetics/AE; Child
- Abstract:
- Objective To compare the effects of dexketamine and sufentanil in the anesthesia of high ligation of laparoscopic hernia sac in children,and to explore the efficacy and safety of dexketamine and sufentanil in pediatric ambulatory surgery.Methods From March 2020 to August 2020,80 children who planned to have laparoscopic high ligation of hernia sac in Hunan Children’s Hospital were selected as the research objects.They were divided into dexketamine group (SK group,n=40) and sufentanil group (SF group,n=40) by random number table method.Anesthesia was induced by intravenous injection of dexketamine 1.0 mg/kg in SK group and sufentanil 0.2 μg/kg in SF group.The hemodynamic changes of the two groups were observed at 7 time points before anesthesia induction (T0),immediately after induction (T1),at the time of laryngeal mask insertion (T2),at the beginning of surgery (T3),5 min after surgery (T4),at the end of surgery (T5),leaving the operating room (T6),postoperative spontaneous breathing recovery time,anesthesia recovery time.Perioperative adverse events,and postoperative agitation and pain scores.Results The recovery time of spontaneous breathing and the recovery time of anesthesia in SK group were 4.2±1.8 min and 24.2±4.5 min,respectively.The recovery time of spontaneous breathing and the recovery time of anesthesia in SF group were 5.1±1.9 min and 29.3±7.3 min,respectively.The difference was statistically significant (P<0.05).In the SK group,the pain scores at 30 min and 1 h after operation were 0(0,0.75) and 0(0,0.75),and the agitation scores were 2(2,2) and 2(2,2),respectively.In SF group,the pain scores at 30 min and 1 h after operation were 1(0,1) and 2(0,4),and the agitation scores were 2(2,2.75) and 2(2,4),respectively.The pain score and agitation score at 30 min and 1 h after operation in SK group were lower than those in SF group,and the differences were statistically significant (P<0.05).Cough occurred in 1 case (1/40,2.5%) in SK group and 7 cases (7/40,17.5%) in SF group,and the difference was statistically significant (P<0.05).The hemodynamic indexes of the two groups were stable at different time points,and the difference was not statistically significant (P>0.05).Conclusion Compared with sufentanil,dexketamine anesthesia induction has stronger sedative and analgesic effects,with earlier postoperative spontaneous recovery,faster recovery,and lower incidence of adverse events.It can be used as a better sedative and analgesic drug choice for high ligation of laparoscopic hernia sac in children.
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Memo
收稿日期:2021-10-27。
基金项目:2021年度湖南省卫生健康委科研立项课题(202104111245)
通讯作者:屈双权,Email:qushuangquan@126.com