Yu Xingyu,Gu Song,Li Yunjie,et al.Recent advance of Wnt/β-catenin signaling pathway in hepatoblastoma[J].Journal of Clinical Pediatric Surgery,,21():688-691.[doi:10.3760/cma.j.cn101785-202107049-018]
Recent advance of Wnt/β-catenin signaling pathway in hepatoblastoma
- Abstract:
- Hepatoblastoma (HB) is the most common liver malignancy in children and its incidence has been rising over the last three decades.Surgery excision and cisplatinum-based chemotherapy are currently major treatments for HB.Numerous researches have demonstrated that Wnt signaling pathway plays important roles in hepatocyte generation, liver development, regeneration and injury repair.Meanwhile, abnormal Wnt/β-catenin signaling pathway, as a major marker of HB, affects the occurrence and development of tumors.And some molecules in the pathway have potential targets.By integrating domestic and foreign researches of HB and Wnt/β-catenin signaling pathway, this review elucidated the mechanism of Wnt/β-catenin signaling pathway, examined its relationship with the occurrence and development of HB, summarized the roles of Wnt/β-catenin signaling pathway in the diagnosis, treatment and prognosis of HB and provided novel rationales for clinical treatment of HB.
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Memo
收稿日期:2021-07-26。
基金项目:1.2021年度国家临床重点专科建设项目：国家儿童医学中心（基于提高临床服务能力为导向的儿童肿瘤多学科合作诊疗体系建设）（2021）；2.浦东新区科技发展基金民生科研（医疗卫生）项目（PKJ2017-Y04）；3.上海交通大学医学院第15期大学生创新训练计划项目（1521Y051，S202210248303）
通讯作者:顾松,Email:gusong@shsmu.edu.cn