Ding Zheyu,Wang Jinhu,Wang Qi,et al.Solid Tumor with hypertension and myocardial hypertrophy in children: report of 3 cases and literature review[J].Journal of Clinical Pediatric Surgery,,21():586-590.[doi:10.3760/cma.j.cn101785-202111043-017]
Solid Tumor with hypertension and myocardial hypertrophy in children: report of 3 cases and literature review
- Keywords:
- Hypertension/ET; Hypertension/TH; Myocardial Hypertrophy; Neuroblastoma/CO; Neuroblastoma/SU; Wilms Tumor/CO; Wilms Tumor/SU; Teratoma/CO; Teratoma/SU; Treatment Outcome
- Abstract:
- Objective The purpose of the study is to analyze the related factors of hypertension and myocardial hypertrophy secondary to solid tumors in children and explore the diagnosis and treatment strategies.Methods Three cases of hypertension and myocardial hypertrophy secondary to solid tumors were admitted to Children’s Hospital Zhejiang University School of Medicine from 2015 to 2020.The treatment process and clinical data were studied retrospectively.The relationship between age, pathological diagnosis, tumor size, tumor location, hypertension and myocardial hypertrophy was analyzed.Results The onset age of the 3 cases were all under 1 year old.All 3 cases presented with abdominal mass and were diagnosed with obvious hypertension after admission Ultrasonography indicated obvious myocardial hypertrophy and decreased left ventricular ejection function.The tumor types of 3 patients included neuroblastoma, nephroblastoma and teratoma.All patients were treated with hypotension and cardiotonic therapy before operation, and the operation was successfully completed under the condition of relatively stable blood pressure.Postoperative blood pressure level gradually returned to normal, cardiac hypertrophy gradually relieved, and cardiac function gradually improved.Conclusion Hypertension could be caused by different tumors through different mechanisms.Hypertension in small infants is difficult to detect early, and persistent hypertension may lead to myocardial hypertrophy and cardiac insufficiency.Complete resection of tumor is the key step in the treatment and in relieving hypertension and improving myocardial hypertrophy and cardiac function.Myocardial hypertrophy in young infants has a good chance of being reversed by early intervention.
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Memo
收稿日期:2021-11-20。
基金项目:浙江省自然科学基金青年项目（LQ20H160027）
通讯作者:舒强,Email:shuqiang@zju.edu.cn