Wang Chuanyu,Jia Zhiming,Zhu Wen,et al.Regional homogeneity in children with severe and non-severe primary monosymptomatic nocturnal enuresis using resting-state functional magnetic resonance imaging[J].Journal of Clinical Pediatric Surgery,,21():347-352.[doi:10.3760/cma.j.cn101785-202110026-010]
Click Copy

Regional homogeneity in children with severe and non-severe primary monosymptomatic nocturnal enuresis using resting-state functional magnetic resonance imaging

Journal of Clinical Pediatric Surgery[ISSN:1671-6353/CN:43-1380/R] volume: 第21卷 Number: 2022 04 Page: 347-352 Column: 论著 Date of publication: 2022-04-28
Author(s):
Wang Chuanyu1;  Jia Zhiming1;  Zhu Wen1;  Zhang Chenyang1;  Che yingyu2;  Wu Yue2;  Zhang Jing2;  Zhang QinYong1;  Wang Yan1;  Wen Jianguo1;  Wang qingwei<
1. Department of Urology, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China;
2 Department of Magnetic Resonance, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
Keywords:
Nocturnal Enuresis/DG; Nocturnal Enuresis/DI; Brain/DG; Resting-state Functional Magnetic Resonance Imaging
DOI:
10.3760/cma.j.cn101785-202110026-010
Abstract:
ObjectiveTo explore the change and difference of regional homogeneity (ReHo) in children with severe and non-severe primary monosymptomatic nocturnal enuresis (PMNE) using resting-state functional magnetic resonance imaging (Rs-fMRI).MethodsA total of 39 PMNE children were selected as research subjects.There were 20 boys and 19 girls with an age range of (11.9±2.6) years.And 33 children with normal lower urinary tract function confirmed by conventional urodynamic and requiring surgery for upper urinary tract diseases were selected as normal control group.According to the weekly frequency of bed wetting nights,PMNE children were divided into two groups of non-severe (bed wetting nights per week≤4) (n=14) and severe (bed wetting nights per week>4)(n=25).Rs-fMRI images were acquired and ReHo difference under the effect of disease was analyzed by one-way ANOVA.Two-sample post hoc t-test was utilized for comparing the differences of brain function characteristics among three groups.ResultsThe dominant disease-affected brain region was supplementary motor area.No statistical difference existed in ReHo between non-severe and severe groups.As compared with control group,left inferior parietal lobule,left inferior frontal gyrus and supplementary motor area were abnormal in non-severe group;right inferior temporal gyrus,left superior frontal gyrus and supplementary motor area were abnormal in severe group.All of the above results were corrected by AlphaSim correction (voxel level P<0.005,P<0.05 after correction were considered statistically different).ConclusionAbnormal functions of inferior parietal lobe,inferior frontal gyrus and supplementary motor area were present in non-severe group and abnormal functions of inferior temporal gyrus,superior frontal gyrus and supplementary motor area in severe group.These abnormal brain regions may be related with the pathological mechanism of PMNE.And the severity of symptoms may not be related with the development of central nervous system in PMNE children.

References:

[1] Austin PF,Bauer SB,Bower W,et al.The standardization of terminology of lower urinary tract function in children and adolescents:Update report from the standardization committee of the International Children’s Continence Society[J].Neurourol Urodyn,2016,35(4):471-481.DOI:10.1002/nau.22751.
[2] Wang XZ,Wen YB,Shang XP,et al.The influence of delay elimination communication on the prevalence of primary nocturnal enuresis-a survey from Mainland China[J].Neurourol Urodyn,2019,38(5):1423-1429.DOI:10.1002/nau.24002.
[3] Nevéus T.Pathogenesis of enuresis:Towards a new understanding[J].Int J Urol,2017,24(3):174-182.DOI:10.1111/iju.13310.
[4] Yeung CK,Sreedhar B,Sihoe JD,et al.Differences in characteristics of nocturnal enuresis between children and adolescents:a critical appraisal from a large epidemiological study[J].BJU Int,2006,97(5):1069-1073.DOI:10.1111/j.1464-410X.2006.06074.x.
[5] 中华医学会小儿外科学分会小儿尿动力和盆底学组和泌尿外科学组.儿童遗尿症诊断和治疗中国专家共识[J].中华医学杂志,2019,99(21):1615-1620.DOI:10.3760/cma.j.issn.0376-2491.2019.21.005. Groups of Pediatric Urodynamics and Pelvic Floor Science and Urology,Pediatric Surgery Branch of Chinese Medical Association:Chinese Expert Consensus on Diagnosis and Treatment of Pediatric Enuresis[J].National Medical Journal of China,2019,99(21):1615-1620.DOI:10.3760/cma.j.issn.0376-2491.2019.21.005.
[6] Nguyen VT,Breakspear M,Cunnington R.Reciprocal interactions of the SMA and cingulate cortex sustain premovement activity for voluntary actions[J].J Neurosci,2014,34(49):16397-16407.DOI:10.1523/jneurosci.2571-14.2014.
[7] Krhut J,Holy P,Tintera J,et al.Brain activity during bladder filling and pelvic floor muscle contractions:a study using functional magnetic resonance imaging and synchronous urodynamics[J].Int J Urol,2014,21(2):169-174.DOI:10.1111/iju.12211.
[8] Zhang H,Reitz A,Kollias S,et al.An fMRI study of the role of suprapontine brain structures in the voluntary voiding control induced by pelvic floor contraction[J].Neuroimage,2005,24(1):174-180.DOI:10.1016/j.neuroimage.2004.08.027.
[9] Kitta T,Mitsui T,Kanno Y,et al.Brain-bladder control network:the unsolved 21st century urological mystery[J].Int J Urol,2015,22(4):342-348.DOI:10.1111/iju.12721.
[10] Griffiths D.Functional imaging of structures involved in neural control of the lower urinary tract[J].Handb Clin Neurol,2015,130:121-133.DOI:10.1016/b978-0-444-63247-0.00007-9.
[11] Zhang K,Ma J,Lei D,et al.Task positive and default mode networks during a working memory in children with primary monosymptomatic nocturnal enuresis and healthy controls[J].Pediatr Res,2015,78(4):422-429.DOI:10.1038/pr.2015.120.
[12] Zhu J,Dong X,Zhao FQ,et al.Event-related potentials of working memory impairment in children with primary nocturnal enuresis[J].Chinese Journal of Contemporary Pediatrics,2018,20(12):1040-1043.DOI:10.7499/j.issn.1008-8830.2018.12.012.
[13] Ives-Deliperi V,Butler JT.Mechanisms of cognitive impairment in temporal lobe epilepsy:A systematic review of resting-state functional connectivity studies[J].Epilepsy Behav,2021,115:107686.DOI:10.1016/j.yebeh.2020.107686.
[14] Ma Z,Wang C,Hines CS,et al.Frontoparietal network abnormalities of gray matter volume and functional connectivity in patients with generalized anxiety disorder[J].Psychiatry Res Neuroimaging,2019,286:24-30.DOI:10.1016/j.pscychresns.2019.03.001.
[15] Hilbert K,Pine DS,Muehlhan M,et al.Gray and white matter volume abnormalities in generalized anxiety disorder by categorical and dimensional characterization[J].Psychiatry Res,2015,234(3):314-320.DOI:10.1016/j.pscychresns.2015.10.009.
[16] 王爱华,廖鸣慧,刘小梅,等.遗尿症儿童情绪状态及其影响因素分析[J].中华实用儿科临床杂志,2016,31(2):136-139.DOI:10.3760/cma.j.issn.2095-428X.2016.02.015. Wang AH,Liao MH,Liu XM,et al.Analysis on emotional sate and the related influencing factors in children with nocturnal enuresis[J].Chin J Appl Clin Pediatr,2016,31(2):136-139.DOI:10.3760/cma.j.issn.2095-428X.2016.02.015.
[17] Papagno C.Memory deficits[J].Handb Clin Neurol,2018,151:377-393.DOI:10.1016/b978-0-444-63622-5.00019-x.
[18] Nishijima S,Sugaya K,Kadekawa K,et al.Effect of chemical stimulation of the medial frontal lobe on the micturition reflex in rats[J].J Urol,2012,187(3):1116-1120.DOI:10.1016/j.juro.2011.10.128.
[19] Griffiths DJ,Fowler CJ.The micturition switch and its forebrain influences[J].Acta Physiol (Oxf),2013,207(1):93-109.DOI:10.1111/apha.12019.
[20] Griffiths D,Tadic SD.Bladder control,urgency and urge incontinence:evidence from functional brain imaging[J].Neurourol Urodyn,2008,27(6):466-474.DOI:10.1002/nau.20549.
[21] Jiang L,Zuo XN.Regional homogeneity:a multimodal,multiscale neuroimaging marker of the human connectome[J].Neuroscientist,2016,22(5):486-505.DOI:10.1177/1073858415595004.
[22] 刘欣健,贾智明,文建国.儿童原发性遗尿发病机制的研究进展[J].临床小儿外科杂志,2018,17(3):231-235.DOI:10.3969/j.issn.1671-6353.2018.03.015. Liu XJ,Jia ZM,Wen JG.Research advances of pathogenesis of primary nocturnal enuresis in children[J].J Clin Ped Sur,2018,17(3):231-235.DOI:10.3969/j.issn.1671-6353.2018.03.015.
[23] Yu B,Chang N,Lu Y,et al.Effect of DRD4 receptor-616 C/G polymorphism on brain structure and functional connectivity density in pediatric primary nocturnal enuresis patients[J].Sci Rep,2017,7(1):1226.DOI:10.1038/s41598-017-01403-1.
[24] Kim JM.Diagnostic value of functional bladder capacity,urine osmolality and daytime storage symptoms for severity of nocturnal enuresis[J].Korean J Urol,2012,53(2):114-119.DOI:10.4111/kju.2012.53.2.114.
[25] 陈咏梅,黄艳,熊琼珍,等.252例儿童夜遗尿症的临床特征分析[J].临床小儿外科杂志,2021,20(6):588-591.DOI:10.12260/lcxewkzz.2021.06.015. Chen YM,Huang Y,Xiong QZ,et al.Retrospective analysis of clinical characteristics of pediatric nocturnal enuresis:a report of 252 case[J].J Clin Ped Sur,2021,20(6):588-591.DOI:10.12260/lcxewkzz.2021.06.015.[ZK)

Memo

收稿日期:2021-10-21;改回日期:。
基金项目:国家自然科学基金(81670689,U1904208);河南省医学攻关科技计划(LHGJ20190167)
通讯作者:王庆伟,Email:qwwang@zzu.edu.cn

Last Update: 1900-01-01