Xia Renpeng,Zou Chanjuan,Zhao Fan,et al.Analysis of risk factors for intestinal stenosis after neonatal necrotizing enterocolitis[J].Journal of Clinical Pediatric Surgery,,21():320-324.[doi:10.3760/cma.j.cn101785-202109042-005]
Analysis of risk factors for intestinal stenosis after neonatal necrotizing enterocolitis
- Keywords:
- Enterocolitis; Necrotizing/DI; Enterocolitis; Necrotizing/SU; Constriction; Pathologic; Intestines; Postoperative Complications; Case-Control Studies
- Abstract:
- ObjectiveTo explore the risk factors of intestinal stenosis after neonatal necrotizing enterocolitis (NEC).MethodsFrom January 2013 to January 2018,retrospective analysis was performed for clinical data of post-NEC intestinal stenosis children and normal controls during the same period.ResultsA total of 132 children were assigned into tow groups of post-NEC intestinal stenosis (stenosis,n=65) and non-stenosis (control,n=67).No inter-group statistical difference existed in general neonatal status,maternal mode of conception,maternal status during pregnancy,operation or not and examination results (P>0.05).Onset age of NEC:stenosis group was greater than control group[8.0(6.0,14.0) vs. 5.0(3.0,8.0) days](P<0.001);no statistical difference existed in leucocyte count or neutrophil ratio of statistical significance (P=0.135,0.486);no obvious inter-group difference existed in platelet count or serum albumin (P=0.283,0.632);C-reactive protein;stenosis group was higher than control group[(71.54±39.14) vs. (48.95±49.61) mg/L,P=0.004];Procalcitonin:stenosis group was higher than control group[(11.91±14.60) vs. (6.14±8.38) ng/mL,P=0.006].According to Logistic regression analysis,NEC’s onset age[OR value=1.115,95%CI(1.035-1.200)],C-reactive protein[OR value=1.014,95%CI (1.005-1.024)]and procalcitonin[OR value=1.039,95%CI (1.001-1.078)]were risk factors for stenosis group.ConclusionGeneral neonatal status,maternal mode of conception,maternal status during pregnancy and operation or not are correlated with post-NEC intestinal stenosis.The later onset age of NEC and the greater possibility of intestinal stenosis.And CRP and PCT are both risk factors for post-NEC stenosis.
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Memo
收稿日期:2021-09-23;改回日期:。
基金项目:湖南省出生缺陷协同防治科技重大专项(2019SK1010)
通讯作者:周崇高,Email:zhouchonggao@sina.com