Deng Shuping,Zeng Yupei,Yuan Cuixia,et al.Diagnosis and treatment of chest wall tumors in children: A Single Center Surgical Experience[J].Journal of Clinical Pediatric Surgery,,21():220-224.[doi:10.3760/cma.j.cn101785-202202011-004]
Diagnosis and treatment of chest wall tumors in children: A Single Center Surgical Experience
- Keywords:
- Thoracic Neoplasms/DI; Thoracic Neoplasms/TH; Thoracic Neoplasms/SU; Treatment Outcome; Child
- Abstract:
- Objective To summarize the experience of diagnosis and surgical treatment of chest wall tumor (CWT) in children and to explore its therapeutic strategies.Methods The clinical data of 127 children (83 males, 44 females) with CWT from January 2011 to December 2021 were analyzed retrospectively.Patients’ median age was 45.62±19.13 months, and average weight was 16.71±8.58 kg.All patients received surgical resection and were followed up regularly after operation.Results There were 126 cases of primary tumors and 1 case of metastatic tumor in the chest wall.Partial tumor resection/biopsy was performed in 5 cases, extended tumor resection in 1 case, and tumor resection in other 121 cases.The operation time was 12-167 min and the intraoperative blood loss was 1-500 mL.Pathological examination showed 115 cases of benign tumors (90.6%), 3 cases of borderline tumors (2.4%), and 9(7.0%) cases of malignant tumors (7%).Eight children with malignant tumors were treated with chemotherapy and/or radiotherapy and targeted drugs.No death occurred during the operation.6 patients dropped out and 121 children were followed up (4.92±2.17) years.3 children with malignant tumors died of distant metastasis, while the rest survived.There were 6 cases undergoing reoperation for local recurrence.Conclusion CWTs in children are hardly seen, but most of which are benign tumors, and have satisfactory surgical results Malignant CWTs in children are rare with poor prognosis.It is necessary to develop a new method for evaluating, diagnosing and treating malignant CWT in children.
References:
[1] 徐启明, 周乃康, 刘颖, 等.105例胸壁肿瘤的诊断和外科治疗[J].中国肿瘤临床, 2007, 34(13):750-753.DOI:10.3969/j.issn.1000-8179.2007.13.009.Xu QM, Zhou NK, Liu Y, et al.Diagnosis and surgical treatment of 105 cases with chest wall tumors[J].Chinese Journal of Clinical Oncology, 2007, 34(13):750-753.DOI:10.3969/j.issn.1000-8179.2007.13.009.
[2] 金煜翔, 赵学维, 王良哲, 等.常见胸壁肿瘤临床诊治分析[J].人民军医, 2019, 62(3):244-246.Jin YX, Zhao XW, Wang LZ, et al.Analysis on the clinical diagnosis and treatment of common chest wall tumor[J].People’s Military Surgeon, 2019, 62(3):244-246.
[3] Van den Berg H, Van Rijn RR, Merks JH.Management of tumors of the chest wall in childhood:a reviews[J].J Pediatr Hematol Oncol, 2008, 30(3):214-221.DOI:10.1097/MPH.0b013e318162bd54.
[4] Tsukushi S, Nishida Y, Sugiura H, et al.Soft tissue sarcomas of the chest wall[J].J Thorac Oncol, 2009, 4(7):834-837.DOI:10.1097/JTO.0b013e3181a97da3.
[5] 中国医师协会胸外科医师分会.胸壁肿瘤切除及胸壁重建手术中国专家共识(2018版)[J].中国胸心血管外科临床杂志, 2019, 26(1):1-7.DOI:10.7507/1007-4848.201809058.Thoracic surgeon branch of Chinese Medical Association. Chinese expert consensus on chest wall tumor resection and reconstruction of chest wall[J].Chinese Journal of Clinical Thoracic and Cardiovascular Surgery, 2019, 26(1):1-7.DOI:10.7507/1007-4848.201809058.
[6] Foroulis CN, Kleontas AD, Tagarakis G, et al.Massive chest wall resection and reconstruction for malignant disease[J].Oncotargets Ther, 2016, 9(1):2349-2358.DOI:10.2147/OTT.S101615.
[7] Anderson CJ, Spruill MD, Wylie EF, et al.A technique for pediatric chest wall reconstruction using custom-designed titanium implants:description of technique and report of two cases[J].J Child Orthop, 2016, 10(1):1-7.DOI:10.1007/s11832-015-0709-1.
[8] Berthet JP, Wihlm JM, Canaud L, et al.The combination of polytetrafluoroethylene mesh and titanium rib implants:an innovative process for reconstructing large full thickness chest wall defectss[J].Eur J Cardiothorac Surg, 2012, 42(3):444-453.DOI:10.1093/ejcts/ezs028.
[9] Kamel M, Port J, Altorki NK.Sternal resections:new materials for reconstructions[J].Curr Surg Rep, 2015, 3(6):16.DOI:10.1007/s40137-015-0094-1.
[10] Wald O, Islam I, Amit K, et al.11-year experience with Chest Wall resection and reconstruction for primary Chest Wall sarcomas[J].J Cardiothorac Surg, 2020, 28, 15(1):29.DOI:10.1186/s13019-020-1064-y.
[11] Dingemann C, Linderkamp C, Weidemann J, et al.Thoracic wall reconstruction for primary malignancies in children:short- and long-term results[J].Eur J Pediatr Surg, 2012, 22(1):34-39.DOI:10.1055/s-0031-1285873.
[12] Weyant MJ, Bains MS, Venkatraman E, et al.Results of chest wall resection and reconstruction with and without rigid prosthesis[J].Ann Thorac Surg, 2006, 81(1):279-285.DOI:10.1016/j.athoracsur.2005.07.001.
[13] Abdel R, Ahman A, Rahouma M, et al.Contributing factors to the outcome of primary malignant chest wall tumors[J].J Thorac Dis, 2017, 12(9):5184-5193.DOI:10.21037/jtd.2017.11.61.
[14] Marulli G, Duranti L, Cardillo G, et al.Primary chest wall chondrosarcomas:results of surgical resection and analysis of prognostic factors[J].Eur J Cardiothorac Surg, 2014, 45(6):e194-e201.DOI:10.1093/ejcts/ezu095.
[15] Krasin MJ, Davidoff AM, Rodriguez-Galindo C, et al.Definitive surgery and multiagent systemic therapy for patients with localized Ewing sarcoma family of tumors:local outcome and prognostic factors[J].Cancer, 2005, 104(2):367-373.DOI:10.1002/cncr.21160.
[16] Zapala MA, Ho-Fung VM, Lee EY.Thoracic neoplasms in children:contemporary perspectives and imaging assessment[J].Radiol Clin North Am, 2017, 55(4):657-676.DOI:10.1016/j.rcl.2017.02.008.
Memo
收稿日期:2022-02-05。
基金项目:重庆市医学科研项目(2016ZDXM013)
通讯作者:李勇刚,Email:yulyg@sina.com