Zhu Yuan,Gao Yijin,Feng Yi,et al.Nutritional status and influencing factors of children with solid tumors during treatment[J].Journal of Clinical Pediatric Surgery,,21():36-40.[doi:10.3760/cma.j.cn.101785-202101003-007]
Click Copy

Nutritional status and influencing factors of children with solid tumors during treatment

Journal of Clinical Pediatric Surgery[ISSN:1671-6353/CN:43-1380/R] volume: 第21卷 Number: 2022 01 Page: 36-40 Column: 论著 Date of publication: 2022-01-28
Author(s):
Zhu Yuan1;  Gao Yijin2;  Feng Yi1;  Pan Liya1;  Fu Huanhuan1;  Hong Li1
1 Department of Clinical Nutrition, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China;
2 Department of Hematology and Oncology, Shanghai Children’s Medical Center, Shanghai Jiao Tong University
Keywords:
Combined Modality Therapy; Nutrition Assessment; Body Mass Index; Response Evaluation Criteria in Solid Tumors; Root Cause Analysis
DOI:
10.3760/cma.j.cn.101785-202101003-007
Abstract:
Objective To explore the effects of risk factors on nutritional status of children with solid tumors during treatment. Methods From November 2019 to August 2020, 109 children with solid tumors were selected as the case group and another 109 age-matched and sex-matched healthy children were chosen as the control group.The clinical data of two groups was collected, and their body composition using bioelectrical impedance analysis was measured to compare the differences in nutritional indicators. Results The children’s nutritional status was defined by the body mass index z-score (BMIZ):BMIZ<-1 indicates malnutrition, -1≤BMIZ≤2 indicates normal.In the case group, 41 (37.6%) patients was malnutrition, 68 (62.4%) was normal.The BMI, fat-free mass index and body cell mass index of the case group were significantly lower than those of the control group.According to the Multivariate Logistic regression analysis, nutritional status at diagnosis, infection and mucositis were the independent factors affecting the nutritional status of children with solid tumors during treatment. Conclusion Children with solid tumors have high incidence of malnutrition.The body composition analysis can facilitate more accurate assessment of nutritional status of children with solid tumors.Malnutrition at diagnosis, infection or mucositis during treatment were the independent influencing factors for nutritional status of children with solid tumors.

References:

[1] Lemos Pdos S,de Oliveira FL,Caran EM.Nutritional status of children and adolescents at diagnosis of hematological and solid malignancies[J].Rev Bras Hematol Hemoter,2014,36(6):420-423.DOI:10.1016/j.bjhh.2014.06.001.
[2] Joffe L,Dwyer S,Glade Bender JL,et al.Nutritional status and clinical outcomes in pediatric patients with solid tumors:A systematic review of the literature[J].Semin Oncol,2019,46(1):48-56.DOI:10.1053/j.seminoncol.2018.11.005.
[3] Murphy AJ,Hill RJ,Buntain H,et al.Nutritional status of children with clinical conditions[J].Clin Nutr,2017,36(3):788-792.DOI:10.1016/j.clnu.2016.05.014.
[4] Sala A,Pencharz P,Barr RD.Children,cancer,and nutrition-A dynamic triangle in review[J].Cancer,2004,100(4):677-687.DOI:10.1002/cncr.11833.
[5] Gaynor EP,Sullivan PB.Nutritional status and nutritional management in children with cancer[J].Arch Dis Child,2015,100(12):1169-1172.DOI:10.1136/archdischild-2014-306941.
[6] Rogers PC,Barr RD.The relevance of nutrition to pediatric oncology:A cancer control perspective[J].Pediatr Blood Cancer,2020,(Suppl3):e28213.DOI:10.1002/pbc.28213.
[7] Bansal D,Totadri S,Chinnaswamy G,et al.Management of Neuroblastoma:ICMR Consensus Document[J].Indian J Pediatr,2017,84(6):446-455.DOI:10.1007/s12098-017-2298-0.
[8] Diakatou V,Vassilakou T.Nutritional Status of Pediatric Cancer Patients at Diagnosis and Correlations with Treatment,Clinical Outcome and the Long-Term Growth and Health of Survivors[J].Children (Basel),2020,7(11):218.DOI:10.3390/children7110218.
[9] Ooi PH,Thompson-Hodgetts S,Pritchard-Wiart L,et al.Pediatric Sarcopenia:A Paradigm in the Overall Definition of Malnutrition in Children?[J].JPEN J Parenter Enteral Nutr,2020,44(3):407-418.DOI:10.1002/jpen.1681.
[10] Caan BJ,Cespedes Feliciano EM,Prado CM,et al.Association of Muscle and Adiposity Measured by Computed Tomography with Survival in Patients with Nonmetastatic Breast Cancer[J].JAMA Oncol,2018,(6):798-804.DOI:10.1001/jamaoncol.2018.0137.
[11] Ritz A,Kolorz J,Hubertus J,et al.Sarcopenia is a prognostic outcome marker in children with high-risk hepatoblastoma[J].Pediatr Blood Cancer,2021,68(5):e28862.DOI:10.1002/pbc.28862.
[12] Chince?an MI,Mǎrginean CO,Voidǎzan S.Assessment of Body Composition in a Group of Pediatric Patients with Cancer:A Single Romanian Center Experience[J].J Pediatr Hematol Oncol,2016,38(7):e217-e222.DOI:10.1097/MPH.0000000000000586.
[13] Murphy AJ,White M,Elliott SA,et al.Body composition of children with cancer during treatment and in survivorship[J].Am J Clin Nutr,2015,102(4):891-896.DOI:10.3945/ajcn.114.099697.
[14] Coletti D.Chemotherapy-induced muscle wasting:an update[J].Eur J Transl Myol,2018,28(2):7587.DOI:10.4081/ejtm.2018.7587.
[15] Shachar SS,Williams GR,Muss HB,et al.Prognostic value of sarcopenia in adults with solid tumours:A meta-analysis and systematic review[J].Eur J Cancer,2016,57:58-67.DOI:10.1016/j.ejca.2015.12.030.
[16] Widjaja NA,Pratama A,Prihaningtyas R,et al.Efficacy Oral Glutamine to Prevent Oral Mucositis and Reduce Hospital Costs During Chemotherapy in Children with Acute Lymphoblastic Leukemia[J].Asian Pac J Cancer Prev,2020,21(7):2117-2121.DOI:10.31557/APJCP.2020.21.7.2117.
[17] Atkins S,He F.Chemotherapy and beyond:infections in the era of old and new treatments for hematologic malignancies[J].Infect Dis Clin North Am,2019,33(2):289-309.DOI:10.1016/j.idc.2019.01.001.
[18] McGrath KH,Hardikar W.Gastrostomy tube use in children with cancer[J].Pediatr Blood Cancer,2019,66(7):e27702.DOI:10.1002/pbc.27702.

Memo

收稿日期:2021-01-03。
基金项目:上海卫建委临床营养重要薄弱学科项目（2019ZB0103）
通讯作者:洪莉,Email:hongliscmc.com.cn

Last Update: 1900-01-01