Zhao Yilin,Wang Haojie,Zhan Jianghua.Recent advances of TGFβ1 induced EMT-related signaling pathways in biliary atresia[J].Journal of Clinical Pediatric Surgery,,20():1189-1193.[doi:10.12260/lcxewkzz.2021.12.017]
Recent advances of TGFβ1 induced EMT-related signaling pathways in biliary atresia
- Keywords:
- Biliary Atresia/ET; Epithelial-Mesenchymal Transition; Transforming Growth Factor Beta1; Liver Cirrhosis
- CLC:
- R722.1;R657.4
- Abstract:
- Biliary atresia (BA) is a disease characterized by progressive inflammation and fibrosis of intra/extrahepatic bile ducts.The cause of disease has remained elsusive.It may be related with virus infection and immune response.The major treatment for BA is Kasai surgery while liver fibrosis is an important factor affecting the prognosis of Kasai surgery.Involved in the process of liver fibrosis, epithelial-mesenchymal transition (EMT) refers to that polarized epithelial cells are released gradually and transformed into cells with mesenchymal characteristics under stimulation.Transforming growth factor-β1 (TGFβ1) induces EMT through TGFβ1/Smad signaling pathway and other TGFβ1/non-Smad signaling pathways.And microRNA affects signaling pathways and participates in the process of liver fibrosis.This review was intended to elaborate the possible pathways associated with TGFβ1 inducing EMT in BA and to provide rationales for delaying liver fibrosis and inhibiting or even reversing EMT process.
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Memo
收稿日期:2020-04-30。
基金项目:国家自然科学基金（编号：81570471）；天津市卫生行业重点攻关项目（编号：14KG129）；新疆维吾尔自治区自然科学基金（2019D01A12）
通讯作者:詹江华,Email:zhanjianghuatj@163.com