Shi Jia,Cheng Qianqian,Wu Zhixiang,et al.Application of near-infrared Indocyanine Green fluorescence imaging in the Surgery of Childhood Hepatoblastoma[J].Journal of Clinical Pediatric Surgery,,20():916-920.[doi:10.12260/lcxewkzz.2021.10.004]
Application of near-infrared Indocyanine Green fluorescence imaging in the Surgery of Childhood Hepatoblastoma
- CLC:
- R917.76;R445.9;R735.7;R726.1
- Abstract:
- Objective Indocyanine green (ICG) has been used for intraoperative real-time navigation in precise liver surgery as it can specifically accumulate in liver cancer tissues.This article explored the application of near-infrared fluorescence imaging with ICG for identifying intraoperative lesions and defining tumor margins for childhood hepatoblastoma (HB).Methods The clinical data of 6 children with HB undergoing ICG fluorescence-guided surgery from December 2019 to May 2021 was resepectively reviewed.ICG at a 0.5 mg/kg body weight dose was injected intravenously to all patients 45-72 hours before the operation.The ICG near-infrared fluorescence imaging system was applied to observe the tumor lesions and resection margins during the operation. Results Of the 6 patients, 5 were presented with single lesion and 1 with multiple lesions (recurrent after surgery).The median tumor diameter was 7.5cm (1-10 cm) and the distance between the tumor and liver capsule was 0 to 15 mm.5 children underwent radical resection of right liver tumor while 1 underwent irregular liver tumor resection.Fluorescence was dected in all liver lesions, and absent at the surgical margin after the operation, which is consistent with the pathological examination.No adverse events related to ICG injection were observed. Conclusion Real-time ICG fluorescence imaging technique during hepatectomy can help to define the resection margin of HB and scattered metastatic lesions in the liver.Whereas the appropriate timing of ICG injection and imaging limitation on the tumor’s depth and size require to be further studied and clarified.
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Memo
收稿日期:2021-04-27。
基金项目:国家自然科学基金（编号：81874234）；苏州市临床医学专家团队引进项目（编号：SZYJTD201706）；上海市市级医院新兴前沿技术联合攻关项目（编号：SHDC12018123）；上海市生物医药领域科技支撑项目（编号：18401931800）；上海市转化医学协同创新中心项目（编号：TM201809）
通讯作者:吕凡,Email:lvfan@xinhuamed.com.cn