Zhang Lin,Zhang Cong,Li Yong,et al.Predictive values of interleukin-6, procalcitonin and C-reactive protein in acute appendicitis with perforation in children[J].Journal of Clinical Pediatric Surgery,,20():749-753.[doi:10.12260/lcxewkzz.2021.08.009]
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Predictive values of interleukin-6, procalcitonin and C-reactive protein in acute appendicitis with perforation in children

Journal of Clinical Pediatric Surgery[ISSN:1671-6353/CN:43-1380/R] volume: 第20卷 Number: 2021 08 Page: 749-753 Column: 论著 Date of publication: 2021-08-10
Author(s):
Zhang Lin1;  Zhang Cong1;  Li Yong2;  Yin Qiang2;  Huang Caizhi1;  Yu Cuihua3
1. Department of Clinical Laboratory, Hunan Children’s Hospital, Changsha 410007, Hunan, China;
2. Department of Pediatric Surgery, Hunan Children’s Hospital, Changsha 410007, Hunan, China;
3. Department of Pharmacy, The Third Hospital of Changsha,
Keywords:
Appendicitis/DI; Interleukin-6; Procalcitonin; C-reactive Protein; Child
CLC:
R574.61;R726
DOI:
10.12260/lcxewkzz.2021.08.009
Abstract:
Objective To explore the predictive values of interleukin-6 (IL-6), procalcitonin (PCT) and C-reactive protein (CRP) in acute appendicitis (AA) with perforation in children. Methods From January 1 to December 31, 2020, clinical data were reviewed retrospectively for 307 hospitalized AA children aged under 18 years at Hunan Children’s Hospital and The Third Hospital of Changsha. Based upon pathological examinations and intraoperative findings, they were divided into two groups of perforation (n=224) and non-perforation (n=83). The levels of IL-6, PCT, CRP, white blood cell (WBC) and neutrophil ratio (n%) were compared between two groups. The diagnostic performance of each parameter was judged by the receiver operating characteristic (ROC). Results No significant inter-group differences existed in age, gender ratio, WBC count or n% (P>0.05). The levels of IL-6, PCT and CRP were higher in perforation group than those in non-perforation group (P<0.05). The sensitivity, specificity and AUC (area under the ROC curve) of IL-6 for diagnosing perforation in AA were 75.3%, 78.2%, 0.777;the sensitivity, specificity and AUC of PCT 54.7%, 80.0%, 0.684;the sensitivity, specificity and AUC of CRP 62.9%, 82.5%, 0.752 respectively. Multiple Logistic regression revealed that IL-6 >36.6 pg/mL (OR=3.869, 95%CI:1.025-14.597) and CRP >57.9 mg/L (OR=4.742, 95%CI:1.248-18.013) could independently predict whether or not AA was accompanied with perforation (P<0.05). Combination of IL-6 and CRP was not superior to single test of each parameter in diagnosing perforation in AA(P>0.05)Conclusion IL-6, PCT and CRP may play a role in discriminating whether or not AA is accompanied with perforation. The diagnostic performance of IL-6 is better than that of PCT/CRP. And IL-6 >36.6 pg/mL and CRP >57.9 mg/L may independently predict perforation in AA.

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收稿日期:2021-04-12。
通讯作者:余翠花,Email:ychxyeyy@sina.com

Last Update: 1900-01-01