Qin Shuangli,Xie Chong,Zhou Ling,et al.Evaluation of matrix metalloproteinase-7 and matrix metalloproteinase-9 as biomarkers in ureteropelvic junction obstruction in children:a preliminary report[J].Journal of Clinical Pediatric Surgery,,20():664-667.[doi:10.12260/lcxewkzz.2021.07.013]
Evaluation of matrix metalloproteinase-7 and matrix metalloproteinase-9 as biomarkers in ureteropelvic junction obstruction in children:a preliminary report
- Keywords:
- Matrix Metalloproteinase 7/AN; Matrix Metalloproteinase 9/AN; Hydronephrosis/DI; Ureteropelvic junctin obstruction/DI
- CLC:
- R726.921.7;R726.912
- Abstract:
- Objective To evaluate the application values of urinary matrix metalloproteinase-7 (MMP-7) and matrix metalloproteinase-9 (MMP-9) as biomarkers in children with ureteropelvic junction obstruction (UPJO).Methods A total of 24 children with unilateral UPJO were recruited along with another 16 healthy controls.The involved side was left (n=18) and right (n=6).And the average age was 5.8 years (37 days to 15 years).Among them,20 children received 99mTc-DTPA (diethylenetriaminepentaacetic acid) renal dynamic imaging and another 16 underwent pyeloplasty.Quantitative urinary protein analysis was performed and urinary creatinine level employed for normalizing protein levels for the biomarkers.Results The creatinine-normalized urinary levels of MMP-7/MMP-9 protein were higher in UPJO children than healthy controls (P<0.05).Moreover,urinary levels of MMP-7/MMP-9 protein were higher in operation group than those in non-operation group.The preoperative levels of MMP-7/MMP-9 protein in 10 children were higher than those post-operation (P<0.05).No significant differences existed in creatinine-normalized urinary levels of MMP-7/MMP-9 in varying degrees of hydronephrosis (P>0.05).And normalized levels of MMP-7/MMP-9 were not correlated with glomerular filtration rate of affected side (r=-0.128,P=0.592; r=-0.157,P=0.507).Conclusion Compared with healthy children,urinary levels of MMP-7/MMP-9 of children with unilateral UPJO were significantly higher.The levels of MMP-7/MMP-9 proteins were also significantly higher in operation group than those in non-operation group and the levels of MMP-7/MMP-9 protein declined during follow-ups at Month 6 post-operation.
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Memo
收稿日期:2020-05-22。
基金项目:新疆维吾尔自治区自然科学基金资助项目基金（编号：2019D01C112）
通讯作者:谢崇,Email:1298147216@qq.com;周玲,Email:zhouling781004@163.com