Yang Jigang,Wang Wei.Value of nuclear medicine renal imaging in the assessment of renal function in pediatric hydronephrosis[J].Journal of Clinical Pediatric Surgery,,20():307-311.[doi:10.12260/lcxewkzz.2021.04.002]
Value of nuclear medicine renal imaging in the assessment of renal function in pediatric hydronephrosis
- Keywords:
- Kidney/RI; Hydronephrosis/DI; Kidney Function Tests; Child
- CLC:
- R726.9;R692.2
- Abstract:
- In nuclear medicine, renal scan includes renal dynamic and static imaging.Diuretic renal dynamic imaging is recommended for pediatric hydronephrosis.It evaluates the nature of hydronephrosis while assessing differential renal function.Different radiotracers are utilized for renal dynamic scan of pediatric hydronephrosis.According to age, 99mTc-EC is recommended for children aged under 2 years and 99mTc-DTPA for those aged over 2 years.When analyzing renal function and renogram curve, clinicians should pay attention to various influencing factors.Glomerular filtration rate(GFR) based upon double plasma method is accurate.However, wider clinical applications are difficult.Based upon renal dynamic imaging, many influencing factors for GFR require comprehensive analyses.Renal static imaging is employed for evaluating the extent and severity of pyelonephritis and renal scar.Also renal function may be evaluated.There are fewer influencing factors of renal static imaging.With recent widespread applications of single photon emission computed tomography/computed tomography(SPECT/CT) in nuclear medicine, 99mTc-DMSA SPECT/CT tomography can more accurately assess the kidney function of pediatric hydronephrosis.This review discussed the uses of nuclear medicine renal imaging in evaluating renal function in pediatric hydronephrosis.
References:
1 Ismaili K,Hall M,Ham H,et al.Evolution of individual renal function in children with unilateral complex renal duplication[J].J Pediatr,2005,147(2):208-212.DOI:10.1016/j.jpeds.2005.03.048.
2 Gordon I,Piepsz A,Sixt R.Guidelines for standard and diuretic renogram in children[J].Eur J Nucl Med Mol Imaging,2011,38(6):1175-1188.DOI:10.1007/s00259-011-1811-3.
3 Tekgül S,Riedmiller H,Hoebeke P,et al.EAU guidelines on vesicoureteral reflux in children[J].Eur Urol,2012,62(3):534-542.DOI:10.1016/j.eururo.2012.05.059.
4 Ulman I,Jayanthi VR,Koff SA.The long-term followup of newborns with severe unilateral hydronephrosis initially treated nonoperatively[J].J Urol,2000,164(3 Pt 2):1101-1105.DOI:10.1097/00005392-200009020-00046.
5 Assmus MA,Kiddoo DA,Hung RW,et al.Initially asymmetrical function on MAG3 renography increases incidence of adverse outcomes[J].J Urol,2016,195(4 Pt 2):1196-1202.DOI:10.1016/j.juro.2015.11.011.
6 张君颀,耿红全.肾积水患儿的肾功能评估与结局预判[J].临床小儿外科杂志,2020,19(3):193-198.DOI:10.3969/j.issn.1671-6353.2020.03.001. Zhang JQ,Geng HQ.Recent advances in renal function evaluations and outcome predictions of pediatric hydronephrosis[J].J Clin Ped Sur,2020,19(3):193-198.DOI:10.3969/j.issn.1671-6353.2020.03.001.
7 Inanir S,Biyikli N,Noshari O,et al.Contradictory supranormal function in hydronephrotic kidneys:fact or artifact on pediatric MAG-3 renal scans?[J].Clin Nucl Med,2005,30(2):91-96.DOI:10.1097/00003072-200502000-00004.
8 Akta? GE,Sar?kaya A.Correction of differential renal function for asymmetric renal area ratio in unilateral hydronephrosis[J].Ann Nucl Med,2015,29(9):816-824.DOI:10.1007/s12149-015-1009-z.
9 Martín-Solé O,Soria-Gondek A,Pérez-Bertólez S,et al.Value of supranormal function on(99m) Tc-mercaptoacetyltriglycine renal scan in paediatric patients with obstructive hydronephrosis[J].BJU Int,2019,124(5):842-848.DOI:10.1111/bju.14781.
10 Piepsz A,Colarinha P,Gordon I,et al.Guidelines for glomerular filtration rate determination in children[J].Eur J Nucl Med,2001,28(3):BP31-36.
11 Caglar M,Gedik GK,Karabulut E.Differential renal function estimation by dynamic renal scintigraphy:influence of background definition and radiopharmaceutical[J].Nucl Med Commun,2008,29(11):1002-1005.DOI:10.1097/MNM.0b013e32830978af.
12 Elbaset MA,Ezzat O,Elgamal M,et al.Supranormal differential renal function in adults with ureteropelvic junction obstruction:Does it really exist?[J].Indian J Urol,2020,36(3):205-211.DOI:10.4103/iju.IJU_109_20.
13 Song SH,Park S,Chae SY,et al.Predictors of renal functional improvement after pyeloplasty in ureteropelvic junction obstruction:clinical value of visually assessed renal tissue tracer transit in(99m) Tc-mercaptoacetyltriglycine renography[J].Urology,2017,108:149-154.DOI:10.1016/j.urology.2017.05.044.
14 Majd M,Bar-Sever Z,Santos AI,et al.The SNMMI and EANM Procedural Guidelines for Diuresis Renography in Infants and Children[J].J Nucl Med,2018,59(10):1636-1640.DOI:10.2967/jnumed.118.215921.
15 中华医学会儿科学分会肾脏学组.泌尿道感染诊治循证指南(2016)[J].中华儿科杂志,2017,55(12):898-901.DOI:10.3760/cma.j.issn.0578-1310.2017.12.005. Group of Nephrology,Branch of Pediatrics,Chinese Medical Association:Evidence-based Guidelines for Diagnosing and Treating Urinary Tract Infections(2016)[J].Chinese Journal of Pediatric,2017,55(12):898-901.DOI:10.3760/cma.j.issn.0578-1310.2017.12.005.
16 Jang SJ,Choi BS,Choi SH.Evaluation of renal function in obstructed ureter model using(99m) Tc-DMSA[J].In Vivo,2020,34(5):2431-2435.DOI:10.21873/invivo.12057.
17 Mattoo TK,Skoog SJ,Gravens-Mueller L,et al.Interobserver variability for interpretation of DMSA scans in the RIVUR trial[J].J Pediatr Urol,2017,13(6):616.e1-e6.DOI:10.1016/j.jpurol.2017.03.040.
18 Yapar AF,Aydin M,Reyhan M,et al.The conditions for which the geometric mean method revealed a more accurate calculation of relative renal function in 99mTc-DMSA scintigraphy[J].Nucl Med Commun,2005,26(2):141-146.DOI:10.1097/00006231-200502000-00011.
19 Ritchie G,Wilkinson AG,Prescott RJ.Comparison of differential renal function using technetium-99m mercaptoacetyltriglycine(MAG3) and technetium-99m dimercaptosuccinic acid(DMSA) renography in a paediatric population[J].Pediatr Radiol,2008,38(8):857-862.DOI:10.1007/s00247-008-0908-8.
20 Cao X,Xu X,Grant FD,et al.Estimation of split renal function with(99m) Tc-DMSA SPECT:comparison between 3D volumetric assessment and 2D coronal projection imaging[J].AJR Am J Roentgenol,2016,207(6):1324-1328.DOI:10.2214/AJR.16.16307.
21 Sarikaya I,Alqallaf A,Sarikaya A.Renal cortical(68) Ga-PSMA PET and(99m) Tc-DMSA Images[J].J Nucl Med Technol,2021,49(1) 30-33.DOI:10.2967/jnmt.120.248922.
22 Akta? GE,Inanir S.Relative renal function with MAG-3 and DMSA in children with unilateral hydronephrosis[J].Ann Nucl Med,2010,24(9):691-695.DOI:10.1007/s12149-010-0397-3.
23 阚英,杨旭,杨吉刚,等.利尿肾动态显像联合超声检查对肾盂输尿管连接部狭窄患儿肾盂成形术手术时机选择和术后疗效评价的临床价值[J].临床和实验医学杂志,2020,19(15):1632-1635.DOI:10.3969/j.issn.1671-4695.2020.15.018. Kan Y,Yang X,Yang JG,et al.Predictive value and surgical timing of diuretic renal scintigraphy plus renal ultrasound for pyeloplasty in UPJO children[J].Journal of Clinical and Experimental Medicine,2020,19(15):1632-1635.DOI:10.3969/j.issn.1671-4695.2020.15.018.
24 阚英,杨旭,张抒欣,等.利尿肾动态显像对儿童肾盂输尿管连接处梗阻肾盂成形术疗效的预测价值[J].中华核医学与分子影像杂志,2020,40(7):389-393.DOI:10.3760/cma.j.cn321828-20200310-00096. Kan Y,Yang X,Zhang SX,et al.Predictive value of diuretic renal scintigraphy after pyeloplasty in children with ureteropelvic junction obstruction[J].Chinese Journal of Nuclear Medicine and Molecular Imaging,2020,40(7):389-393.DOI:10.3760/cma.j.cn321828-20200310-00096.
25 Kwatra N,Shalaby-Rana E,Majd M.Scintigraphic features of duplex kidneys on DMSA renal cortical scans[J].Pediatr Radiol,2013,43(9):1204-1212.DOI:10.1007/s00247-013-2619-z.
26 Sarikaya I,Sarikaya A.Current status of radionuclide renal cortical imaging in pyelonephritis[J].J Nucl Med Technol,2019,47(4):309-312.DOI:10.2967/jnmt.119.227942.
Memo
收稿日期:2021-01-18。
基金项目:国家自然科学基金(编号:81971642)
作者简介:杨吉刚,Email:yangjigang@ccmu.edu.cn