Huang Zihan,Zheng Shan.Research advances of gamma-glutamyltransferase in the diagnosis and prognosis of biliary atresia disease[J].Journal of Clinical Pediatric Surgery,,20():140-144,160.[doi:10.12260/lcxewkzz.2021.02.007]
Research advances of gamma-glutamyltransferase in the diagnosis and prognosis of biliary atresia disease
- CLC:
- R657.4+4 R726
- Abstract:
- As a common diseases in pediatric surgery,biliary atresia (BA) is difficult for an early diagnosis and has an unsatisfactory prognosis.Gamma-glutamyltransferase (GGT),as a key enzyme involved in glutathione metabolism,is widely found in various tissues of human body.It is located on the external surface of cellular membranes.GGT in liver is mainly located on the cytoplasm of hepatocyte and intrahepatic biliary epithelial cells.Blockage of bile duct system due to BA causes an accumulation of GGT in liver and secretion of excess GGT into circulation.And GGT had a close relationship with early diagnosis and prognosis of BA.Here the relevant researches on GGT in BA hve been reviewed for providing rationales for clinical guidance.
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Memo
收稿日期:2019-12-02。
基金项目:国家自然科学基金(编号:81974059)
通讯作者:郑珊,Email:szheng@shmu.edu.cn