Wu Xiaoxia,Ren Hongxia,Jin Yuanyuan,et al.Risk factors of native liver survival time under 2 years after Kasai operation for biliary atresia[J].Journal of Clinical Pediatric Surgery,,20():114-118.[doi:10.12260/lcxewkzz.2021.02.003]
Risk factors of native liver survival time under 2 years after Kasai operation for biliary atresia
- Keywords:
- Biliary Atresia/SU; Prognosis; Native Liver Survival; Risk Factors
- CLC:
- R657.4+4 R726.1
- Abstract:
- Objective To explore the risk factors of native liver survival (NLS) time under 2 years after Kasai operation for biliary atresia (BA).Methods Clinical and follow-up data were retrospectively analyzed for all children undergoing Kasai operation for BA from January 2009 to June 2017.According to whether or not NLS time was under 2 years,they were divided into survival and death groups.BA classification,gender,cytomegalovirus (CMV) infection,age at Kasai,postoperative antibiotic and hormone regimens,postoperative early cholangitis and jaundice clearance were independent variables.Kaplan-Meier survival analysis was employed for plotting the survival curves of two groups and log-rank test performed for assessing the inter-group difference.Cox proportional hazard models were constructed for assessing the risk factors of native liver survival time under 2 years.Within 3 months,the risk of NLS time under 2 years for non-clearing group was 5.65 folds of that for clearing group (95%CI:2.45-13.04).Results There were 46 cases in survival group and 78 in death group.And 2-year NLS rate was 37.1%.Univariate analysis showed that statistically significant difference existed in survival curve between two variables associated with postoperative early cholangitis and jaundice clearance (P<0.05).COX proportional risk model analysis indicated that failure of jaundice clearance within 3 months after Kasai operation was an independent risk factor for NLS time <2 years.Conclusion Failure of jaundice clearance within 3 months is a risk factor for NLS time under 2 years after Kasai operation for biliary atresia.
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Memo
收稿日期:2020-05-06。
基金项目:山西省重点研发计划项目（编号：201803D31181）；山西省儿童医院院内课题（编号：201928）；山西省儿童医院院内课题（编号：201943）
通讯作者:任红霞,Email:renhongxia100@sina.com