Du Xiaobin,Hu Bo,Dai Chunjuan,et al.Influencing factors of anorectal complications of sacrococcygeal teratoma in neonates[J].Journal of Clinical Pediatric Surgery,,20():39-43.[doi:10.12260/lcxewkzz.2021.01.008]
Influencing factors of anorectal complications of sacrococcygeal teratoma in neonates
- Keywords:
- Sacrococcygeal Region/AB; Teratoma/DI; Teratoma/SU; Treatment Outcome; Recovery of Function; Infant; Newborn
- CLC:
- R730.269;R726.1
- Abstract:
- Objective To explore the effects of risk factors on anorectal complications of sacrococcygeal teratoma (SCT).Methods From August 2013 to February 2018,a total of 97 SCT neonates were recruited.Their clinical characteristics and occurrences of anorectal complications were recorded.Results Clinical classification of sacrococcygeal teratoma and size of surgical residue were correlated with the recovery of postoperative anorectal functions.And other factors,including gender,serum level of alpha-fetoprotein (AFP),tumor size,tumor properties and pathological types were not significant risk factors of anorectal dysfunctions (P>0.05).In Altman types Ⅱ& Ⅲ,statistically significant difference in tumor size between those with anorectal dysfunctions and those without (P<0.05) whereas type Ⅰshowed no statistical difference (P>0.05).Conclusion The anorectal function is associated with a variety of factors,preoperative to Altman accurate classification,tumor size and location of tumor,which can effectively avoid tumors growth,tumors of pelvic floor,around the anus rectum tissue and nerve oppression and aggression,also can avoid intraoperative to important organs of tissue damage,and prevent end-organ damage,improve the long-term prognosis of patients.
References:
1 Yao W,Li K,Zheng S,et al.Analysis of recurrence risks for sacrococcygeal teratoma in children[J].J Pediatr Surg,2014,49(12):1839-1842.DOI:10.1016/j.jpedsurg.2014.09.036.
2 Hambraeus M,Al-Mashhadi A,Wester T,et al.Functional outcome and health-related quality of life in patients with sacrococcygeal teratoma-a Swedish multicenter study[J].J Pediatr Surg,2019,54(8):1638-1643.DOI:10.1016/j.jpedsurg.2018.10.044.
3 Altman RP,Randolph JG,Lilly JR.Sacrococcygeal teratoma:American Academy of Pediatrics Surgical Section Survey-1973[J].J Pediatr Surg,1974,9(3):389-398.DOI:10.1016/s0022-3468(74)80297-6.
4 Holschneider A,Hutson J,Pena A,et al.Preliminary report on the International Conference for the Development of Standards for the Treatment of Anorectal Malformations[J].J Pediatr Surg,2005,40(10):1521-1526.DOI:10.1016/j.jpedsurg.2005.08.002.
5 Huddart SN,Mann JR,Robinson K,et al.Sacrococcygeal teratomas:the UK Children’s Cancer Study Group’s experience.I.Neonatal[J].Pediatr Surg Int,2003,19(1-2):47-51.DOI:10.1007/s00383-002-0884-2.
6 Van Mieghem T,Al-Ibrahim A,Deprest J,et al.Minimally invasive therapy for fetal sacrococcygeal teratoma:case series and systematic review of the literature[J].Ultrasound Obstet Gynecol,2014,43(6):611-619.DOI:10.1002/uog.13315.
7 Frazier AL,Weldon C,Amatruda J.Fetal and neonatal germ cell tumors[J].Semin Fetal Neonatal Med,2012,17(4):222-230.DOI:10.1016/j.siny.2012.05.004.
8 Barreto MW,Silva LV,Barini R,et al.Alpha-fetoprotein following neonatal resection of sacrococcygeal teratoma[J].Pediatr Hematol Oncol,2006,23(4):287-291.DOI:10.1080/08880010600629056.
9 Berger M,Heinrich M,Lacher M,et al.Postoperative bladder and rectal function in children with sacrococcygeal teratoma[J].Pediatr Blood Cancer,2011,56(3):397-402.DOI:10.1002/pbc.22887.
10 Buyukpamukcu M,Varan A,Kupeli S,et al.Malignant sacrococcygeal germ cell tumors in children:a 30-year experience from a single institution[J].Tumori,2013,99(1):51-56.DOI:10.1700/1248.13788.
11 Sarbu I,Socolov D,Socolov R,et al.Hydrocephalus secondary to chemotherapy in a case of prenatally diagnosed giant immature grade 3 sacrococcygeal teratoma:A case report and literature review[J].Medicine (Baltimore),2016,95(43):e5244.DOI:10.1097/md.0000000000005244.
12 Derikx JP,Backer A,van de Schoot L,et al.Long-term functional sequelae of sacrococcygeal teratoma:a national study in the Netherlands[J].J Pediatr Surg,2007,42(6):1122-1126.DOI:10.1016/j.jpedsurg.2007.01.050.
13 Partridge EA,Canning D,Long C,et al.Urologic and anorectal complications of sacrococcygeal teratomas:prenatal and postnatal predictors[J].J Pediatr Surg,2014,49(1):139-143.DOI:10.1016/j.jpedsurg.2013.09.042.
14 Wang Y,Wu Y,Wang L,et al.Analysis of recurrent sacrococcygeal teratoma in children:Clinical features,relapse Risks,and anorectal functional sequelae[J].Med Sci Monit,2017,23:17-23.DOI:10.12659/msm.900400.
15 王乐纯,杨强,马成海.小儿骶尾部畸胎瘤的手术治疗[J].临床肿瘤学杂志,2009,14(3):242-244.DOI:10.3969/j.issn.1009-0460.2009.03.014.Wang LC,Yang Q,Ma CH.Experiences of surgical treatment of sacrococcygeal teratoma in children[J].Journal of clinical oncology,2009,14(3):242-244.DOI:10.3969/j.issn.1009-0460.2009.03.014.
16 Cost NG,Geller JI,Le LD,et al.Urologic co-morbidities associated with sacrococcygeal teratoma and a rational plan for urologic surveillance[J].Pediatr Blood Cancer,2013,60(10):1626-1629.DOI:10.1002/pbc.24627.
17 Le LD,Alam S,Lim FY,et al.Prenatal and postnatal urologic complications of sacrococcygeal teratomas[J].J Pediatr Surg,2011,46(6):1186-1190.DOI:10.1016/j.jpedsurg.2011.03.045.
18 Kremer ME,Derikx JP,van Baren R,et al.Patient-reported defecation and micturition problems among adults treated for sacrococcygeal teratoma during childhood-The need for new surveillance strategies[J].Pediatr Blood Cancer,2016,63(4):690-694.DOI:10.1002/pbc.25857.
Memo
收稿日期:2019-07-04。
通讯作者:胡博,Email:surgeyhubo@163.com