Jiang Hongfei,Lin Tao,Shi Qinlin.Research advances in the treatments of Wilms’ tumor[J].Journal of Clinical Pediatric Surgery,,19():916-920.[doi:10.3969/j.issn.1671-6353.2020.10.010]
Research advances in the treatments of Wilms’ tumor
- Keywords:
- Wilms Tumor; Therapy; Research
- CLC:
- R737.11;R730.5
- Abstract:
- Occurring mostly within 1-3 years of age,nephroblastoma is a common retroperitoneal tumor with an incidence of around 0.8/100,000.Most cases present with abdominal masses and few have hypertension,hematuria,urinary tract infection,fever and anorexia.Due to a lack of typical clinical symptoms,some cases develop severe pain due to tumor bleeding and rupture.Over the last three decades,with the in-depth mechanistic understandings and improved treatments,its 5-year overall survival has spiked from 25% to around 90% thanks to multidisciplinary interventions of chemotherapy,surgery and radiotherapy.However,its recurrent rate has hovered around 15%.Thus an early detection of tumor recurrence and metastasis is essential.This article offers a brief review of the latest treatments and researches of nephroblastoma.The objective is to optimize individual treatment protocols,strengthen their follow-ups and further improve their overall survival.
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Memo
收稿日期:2019-02-10。
基金项目:重庆市渝中区科研项目（编号：20180155）
通讯作者:林涛,Email:lintao272@aliyun.com