Wang Jinhu,Cai Jiabin,Li Minju,et al.Recent international and domestic advances in the diagnosis and treatment of Wilms tumor[J].Journal of Clinical Pediatric Surgery,,19():765-774.[doi:10.3969/j.issn.1671-6353.2020.09.002]
Recent international and domestic advances in the diagnosis and treatment of Wilms tumor
- Keywords:
- Surgery; Chemotherapy; Wilms tumor; Nephroblastoma; Diagnosis; Treatment
- CLC:
- R726.9;R737.11
- Abstract:
- Wilms tumor (WT) is the most common renal malignant tumor in children.This review was intended to present current standard processes of diagnosing and treating WT around the world.Two major international collaboration groups dedicated for the study of WT are Children’s Oncology Group (COG,USA) and International Society of Paediatric Oncology (SIOP,Europe).COG has recommended primary surgery before any adjuvant treatment while SIOP trials tend to focus upon preoperative chemotherapy.Here the diagnostics,genomics and related syndromes of WT were summarized.Also histological classifications,risk stratifications,clinical stages and therapeutics of WT in COG/SIOP were analyzed.Current Chinese diagnosis and treatment consensus was discussed.Despite overall favorable survival outcomes of most WT children,further efforts should be made for minimizing late effects and formulating strategies for more accurate risk-stratified application of chemoradiotherapy.Surgeons must be more cognizant of the latest treatment protocols to achieve the most optimal outcomes for WT children.
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Memo
收稿日期:2020-07-22。
基金项目:浙江省科技计划项目（编号：2017C33047）；浙江省教育厅科研项目（编号：N20140124）
通讯作者:李民驹,Email:minjuli@qq.com