Du Zhen,Xiang Zhen,Wei Siwei,et al.Clinical study of dexmedetomidine in enhancing perioperative comfort during daytime pediatric surgery[J].Journal of Clinical Pediatric Surgery,,19():622-626.[doi:10.3969/j.issn.1671-6353.2020.07.012]
Clinical study of dexmedetomidine in enhancing perioperative comfort during daytime pediatric surgery
- Keywords:
- Anesthesia and Analgesia; Dexmedetomidine; Comfort; Day Surgery; Child
- CLC:
- R614.1;R726.1
- Abstract:
- Objective To compare the efficacies of dexmedetomidine versus midazolam on perioperative comfort during daytime pediatric surgery.Methods Ninety 6-11-year-old children scheduled for elective hernia repair and classified as American Society of Anesthesiologists (ASA)Ⅰ-Ⅱ were randomly divided into midazolam group (M,n=45) and dexmedetomidine group (D,n=45).In group M,midazolam was pumped at a preoperative rate of 0.08 mg/kg and dexmedetomidine at 0.5 ug/kg in group D.Preoperative anxiety,intraoperative hemodynamic changes,stress reactions,postoperative agitations and pain scores were compared between two groups.Results No significant inter-group statistical difference existed in score of separation anxiety.Blood pressure (BP) and heart rate (HR) were significantly lower in group D than those in group M (P<0.01) and the concentrations of tumor necrosis factor (TNF),interleukin-6 (IL-6),cortisol and malondialdehyde (MDA) were also significantly lower in group D than those in group M (P<0.05).No inter-group statistical difference existed in duration of recovery room.Pain scores were significantly lower in group D than those in group M at 2 hours and 1 day postoperatively (P<0.01).However,no significant difference existed at 1 week postoperatively (P>0.05).The comfort scores of group D were higher than those of group M at 2 hours,1 day and 1 week postoperatively (P<0.05).Conclusion As compared with midazolam,dexmedetomidine can better alleviate stress reactions,postoperative agitations and postoperative pain and boost postoperative satisfaction during pediatric daytime surgery.
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Memo
收稿日期:2019-10-28。
基金项目:湖南省卫生计划生育委员会项目（编号：B2016042）
通讯作者:屈双权,Email:qushuangquan1974@163.com