Wang Min,Zhao Sijun,Xiao Zhirong,et al.Analysis of independent risk factors for congenital microtia[J].Journal of Clinical Pediatric Surgery,,19():534-537,543.[doi:10.3969/j.issn.1671-6353.2020.06.014]
Analysis of independent risk factors for congenital microtia
- Keywords:
- Ear/AB; Pregnant Woman; Risk Factors
- CLC:
- R764.7;R726.2
- Abstract:
- Objective To explore the independent risk factors of congenital microtia (CM) through an epidemiological survey.Methods With a case-control study design from June 2016 to June 2018,a total of 80 CM children were assigned into case group for auricular reconstruction.And another 80 children of exudative otitis media were selected as control group.Through parental interviews and questionnaire survey,social demographic profiles,peripartum living environment,diseases,drug use during pregnancy and living habits were recorded.Chi-square test and unconditional Logistic regression were employed for single and multiple factors analysis.Results Maternal education level (OR=2.440,95%CI:1.242-4.191),infection in early pregnancy (OR=4.933,95%CI:1.702-14.300),medical history in early pregnancy (OR=3.773,95%CI:1.433-9.937),indoor decoration or new furniture in peripartum living places (OR=4.267,95%CI:1.580-11.527),frequency of passive maternal smoking (OR=1.430,95%CI:1.115-1.835) and parental occupational exposure to harmful factors (OR=2.962,95%CI:1.469-5.976) were independent risk factors for congenital microtia.Conclusion The occurrence of congenital microtia is correlated with a variety of factors.And it is vital to boost the awareness of peripartum self-care.
References:
1 Ali K,Mohan K,Liu YC.Otologic and audiology concerns of microtia repair[J].Semin Plast Surg,2017,31(3):127-133.DOI:10.1055/s-0037-1603957.
2 Canfield MA,Langlois PH,Nguyen LM,et al.Epidemiologic features and clinical subgroups of anotia/microtia in Texas[J].Birth Defects Res A Clin Mol Teratol,2009,85(11):905-913.DOI:10.1002/bdra.20626.
3 Byun S,Hong P,Bezuhly M.Public perception of the burden of microtia[J].J Craniofac Surg,2016,27(7):1665-1669.DOI:10.1097/SCS.0000000000002900.
4 Anghinoni M,Bailleul C,Magri AS.Auricular reconstruction of congenital microtia:personal experience in 225 cases[J].Acta Otorhinolaryngol Ital,2015,35(3):191-197.
5 蒋海越,潘博,林琳.先天性小耳畸形的分型及治疗策略[J].中华耳科学杂志,2013,11(4):476-480.DOI:10.3969/j.issn.1672-2922.2013.04.001.Jiang HY,Pan B,Lin L.Classification system of congenital microtia and therapeutic strategies[J].Chinese Journal of Otology,2013,11(4):476-480.DOI:10.3969/j.issn.1672-2922.2013.04.001.
6 张天宇,陈颖.先天性外中耳畸形综合征的诊治原则[J].临床耳鼻咽喉头颈外科杂志,2018,32(12):883-885. DOI:10.13201/j.issn.1001-1781.2018.12.001.Zhang TY,Chen Y.Principles for diagnosis and clinical management of syndromic microtia[J].J Clin Otorhinolaryngol Head Neck Surg,2018,32(12):883-885.DOI:10.13201/j.issn.1001-1781.2018.12.001.
7 Sanjib T,Jue Z,Meng X.Risk factors of microtia:a systematic review and meta-analysis[J].Eur J Plast Sur,2016,39(5):335-344.DOI:10.1007/s00238-016-1196-4.
8 林晓倩,王景美,刘景丽,等.巨细胞病毒宫内感染与胎儿严重畸形的相关性[J].中华围产医学杂志,2015,18(11):818-822.DOI:10.3760/cma.j.issn.1007-9408.2015.11.005.Lin XQ,Wang JM,Liu JL,et al.Congenital cytomegalovirus infection in severe fetal malformations[J].Chin J Perinat Med,2015,18(11):818-822.DOI:10.3760/cma.j.issn.1007-9408.2015.11.005.
9 Ahn MR,Li L,Shon J.Teratogenic drugs and their drug interactions with hormonal contraceptives[J].Clin Pharmacol Ther,2016,100(3):217-219.DOI:10.1002/cpt.384.
10 Lagan BM,Dolk H,White B,et al.Assessing the availability of the teratogenic drug isotretinoin outside the pregnancy prevention programme:a survey of e-pharmacies[J].Pharmacoepidemiol Drug Saf,2014,23(4):411-418.
11 李丽萍,刘秀芳,虎明明,等.孕期及哺乳期经口邻苯二甲酸二(2-乙基己基)酯染毒对大鼠的生殖毒性[J].环境与健康杂志,2009,26(11):944-946. DOI:10.16241/j.cnki.1001-5914.2009.11.032.Li LP,Liu XF,Hu MM,et al.Reproductive toxicity of phthalate (2-ethylhexyi) ester by oral exposure during pregnancy and lactation in rats[J].J Environ Health,2009,26(11):944-946. DOI:10.16241/j.cnki.1001-5914.2009.11.032.
12 Rocha RS,Bezerra SC,Lima JW,et al.Consumption of medications,alcohol and smoking in pregnancy and assessment of teratogenic risks[J].Rev Gaucha Enferm,2013,34(2):37-45.DOI:10.1590/s1983-14472013000200005.
13 南奕,王立立,陈心悦,等.中国女性对吸烟和二手烟危害认知及二手烟暴露情况分析[J].中国慢性病预防与控制,2015,23(6):443-445.DOI:10.16386/j.cjpccd.issn.1004-6194.2015.06.011. Nan Y,Wang LL,Chen XY,et al.Knowledge of smoking and hazards of second-hand smoking and exposure status of second-hand smoking[J].Chinese Journal of Prevention and Control of Chronic Diseases,2015,23(6):443-445.DOI:10.16386/j.cjpccd.issn.1004-6194.2015.06.011.
14 陈威,李天雅,张如鸿,等.父母围孕期环境暴露与0~10岁儿童小耳畸形发病相关性的病例对照研究[J].环境与职业医学,2017,34(4):285-290.DOI:10.13213/j.cnki.jeom.2017.16700. Chen W,Li TY,Zhang RH,et al.Case-control study on associations between parental environmental exposure during peri-conceptional period and microtia in children 0-10 years of age[J].Journal of Environmental & Occupational Medicine,2017,34(4):285-290.DOI:10.13213/j.cnki.jeom.2017.16700.
Memo
收稿日期:2019-10-08。
基金项目:湖南省出生缺陷防治科技重大专项（编号：2019SK1010）；湖南省卫健委课题（编号：20200687）；湖南省儿童医院院级课题（编号：B24）
通讯作者:赵斯君,Emall:zhaosj3991@sohoo.com