Lin Xiangshang,Deng Licai,Yao Jiaxing,et al.Clinical effects of interventional sclerotherapy for lymphatic malformation[J].Journal of Clinical Pediatric Surgery,,19():518-522.[doi:10.3969/j.issn.1671-6353.2020.06.011]
Clinical effects of interventional sclerotherapy for lymphatic malformation
- Keywords:
- Lymphatic Abnormalities; Ultrasonography; Interventional; Sclerothrapy
- CLC:
- R551.5;R725.5;R733.4
- Abstract:
- Objective To explore the clinical protocols and efficacies of lymphatic malformation and examine the efficacy and safety of interventional sclerotherapy for lymphatic malformation.Methods A total of 29 children with focal lymphatic malformations on head,neck,trunk and extremities were recruited.Age of treatment,choice of sclerosing agent and sclerotherapy were reviewed.The volume or size of cyst before and after treatment was evaluated and classified into the following four categories of excellent/volume reduction>90%,medium/volume reduction>50%,insignificant/volume reduction<50% and no response.The fine and medium responses were markedly effective.Results The clinical types were giant cysts (n=8),microcystic (n=8) and mixed (n=13).The average course of treatment was 1.62 times,including once (n=18),twice (n=4) and thrice or more (n=7).The average number of treatments for giant cysts was 1.375 and 6 cases were treated once; the average number of mixed was 1.46 and 9 cases were treated once; the average number of microcapsule was 2.13 and all treated>2 times.The follow-up time after treatment was 3 to 24 months.The excellent rate accounted for 58.7%(17/29),the medium rate 31%(9/29) and the insignificant rate 10.3%(3/29).Among them,giant cystic type had a significant effective rate of 100%(excellent 100%),mixed type 92.3%(excellent 53.8%,medium 38.5%) and microcystic type 75%(excellent 25%,medium 50%).No statistically significant difference in significant effectiveness existed among three types (χ2=2.336,P=0.431).However,the excellent rates of three different types of lymphatic malformations were compared and the difference was statistically significant (χ2=9.77,P=0.009).Further inter-group comparison showed that the excellent rate of giant cystic type was significantly higher than that of microcystic type (P=0.007) and no significant difference existed between mixed and macrocapsule types (P=0.046) or microcapsule type (P=0.367).There were postoperative complications of fever (n=2),intracapsular hemorrhage (n=3),localized hyperpigmentation (n=2) and infection (n=1).And there was no onset of anaphylactic shock or local tissue necrosis.Conclusion Interventional sclerotherapy has a significant effect on lymphatic malformation.The therapeutic efficacy of giant cystic lymphangioma is the best,followed by mixed and microcapsules.With a low incidence of complications,interventional sclerotherapy may used as a primary choice for focal lymphatic malformation.
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Memo
收稿日期:2019-08-08。
作者简介:林向上,Email:66887151@qq.com