Wei Yuanyuan,Fan Jinnan,Li Yarui.Meta-analysis of the relationship between single nucleotide polymorphism of rs17095355 and biliary atresia[J].Journal of Clinical Pediatric Surgery,,19():496-502.[doi:10.3969/j.issn.1671-6353.2020.06.007]
Meta-analysis of the relationship between single nucleotide polymorphism of rs17095355 and biliary atresia
- Keywords:
- Biliary Atresia/ET; Meta-Analysis; Genes
- CLC:
- R722;R575.7;R725.7
- Abstract:
- Objective To systematically evaluate the association between single nucleotide polymorphism of rs17095355 genetic susceptibility and biliary atresia (BA).Methods The literature retrieval was conducted by searching the English databases (PubMed,EMbase & Web of Science) and Chinese databases (CNKI,Wanfang,VIP & SinoMed) for the publications on the association between single nucleotide polymorphism of rs17095355 genetic susceptibility and BA by late July 2019.Meta-analysis was performed with software Stata 14.0.Results Seven reports and 8 independent studies were retrieved.Significant associations existed between higher risk of BA and single nucleotide polymorphism of rs17095355.The combined OR were 1.66(1.44-1.90) in allele,1.66(1.38-2.01) in dominant and 2.16(1.38-3.37) in recessive genetic model respectively (all P<0.05).The combined OR in allele genetic model was 1.72(1.48-1.99) in Asian populations (P<0.05).Sample size subgroup analysis showed lower heterogeneity.Conclusion There is significant association between BA and single nucleotide polymorphism of rs17095355,especially in Asian populations.T allele is a high-risk gene for BA.The results should be confirmed by larger high-quality samples from different ethnic groups.
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Memo
收稿日期:2019-07-26。
基金项目:山西医科大学省级博士基金项目（编号：SD1828）
通讯作者:李亚蕊,Email:zyl3212008@sina.com