Wu Xiaojuan,Yi Bin,Wang Xiaolin,et al.Diagnosis and treatment strategies for thyroglossal duct cyst plus papillary thyroid carcinoma[J].Journal of Clinical Pediatric Surgery,,19():451-454.[doi:10.3969/j.issn.1671-6353.2020.05.015]
Diagnosis and treatment strategies for thyroglossal duct cyst plus papillary thyroid carcinoma
- Keywords:
- Thyroglossal Cyst; Carcinoma; Papillary; Thyroid Gland; Thyroidectomy; Child
- CLC:
- R726;R581;R730.261
- Abstract:
- Objective To analyze the clinical profiles of thyroglossal duct cyst with thyroid papillary carcinoma and explore the diagnostics and therapeutics of this rare disease.Methods Three girls were aged 27,53 and 9 years respectively.The major symptoms were cervical or submental cystic mass.One patient was diagnosed preoperatively as papillary thyroid cancer by fine needle puncture and bilateral total thyroidectomy was performed after a confirmation of intraoperative frozen section.Another two patients underwent mass resection alone initially.Postoperative pathological examination revealed malignant lesions and bilateral thyroidectomy and/or bilateral lymphadenectomy were performed.Postoperative treatment of iodine 131I was offered.Results All operations were completed successfully without blood transfusion.All children were discharged within 7 days post-operation.Children 1 and 2 survived asymptomatically for 5 and 4 years without recurrence.Thyroxine supplementation normalized the levels of thyroid hormone.Patient 3 had multiple pulmonary nodules in 2 months after operation.After a treatment of 131I,no obvious lesions were found within 3 months.Conclusion Bilateral total thyroidectomy is effective for children with thyroglossal duct cyst with thyroid papillary carcinoma.Postoperative 131I therapy reduces recurrence.Supplementation of exogenous thyroxine may maintain hormone levels and promote the growth and development.
References:
1 Rathod JK,Rathod SJ,Kadam V.Papillary carcinoma of thyroid in a thyroglossal cyst[J].J Oral Maxillofac Pathol,2018,22(4):98.DOI:10.4103/jomfp.JOMFP_173_16.
2 Choi YM,Kim TY,Song DE,et al.Papillary thyroid carcinoma arising from a thyroglossal duct cyst:a single institution experience[J].Endocr J,2013,60(5):665-670.DOI:10.1507/endocrj.EJ12-0366.
3 Thompson LD,Herrera HB,Lau SK.A Clinicopathologic Series of 685 Thyroglossal Duct Remnant Cysts[J].Head Neck Pathol,2016,10(4):465-474.DOI:10.1007/s12105-016-0724-7.
4 Rossi ED,Martini M,Straccia P,et al.Thyroglossal duct cyst cancer most likely arises from a thyroid gland remnant[J].Virchows Arch,2014,465(1):67-72.DOI:10.1007/s00428-014-1583-9.
5 Hassan MJ,Rana S,Khan S,et al.An Incidental Primary Papillary Carcinoma Arising in a Thyroglossal Duct Cyst:Report of a Rare Finding[J].J Lab Physicians,2016,8(1):62-64.DOI:10.4103/0974-2727.176236.
6 Thompson L,Herrera HB,Lau SK.Thyroglossal Duct Cyst Carcinomas in Pediatric Patients:Report of Two Cases with a Comprehensive Literature Review[J].Head Neck Pathol,2017,11(4):442-449.DOI:10.1007/s12105-017-0807-0.
7 Albayrak Y,Albayrak F,Kaya Z,et al.A case of papillary carcinoma in a thyroglossal cyst without a carcinoma in the thyroid gland[J].Diagn Cytopathol,2011,39(1):38-41.DOI:10.1002/dc.21356.
8 Dzodic R,Buta M,Markovic I,et al.Surgical management of well-differentiated thyroid carcinoma in children and adolescents:33 years of experience of a single institution in Serbia[J].Endocr J,2014,61(11):1079-1086.DOI:10.1507/endocrj.ej14-0226.
9 Palomino MB,Beristain HJ,Piscil SM,et al.Thyroglossal cyst as primary site of papillary thyroid carcinoma metastatic to jugular lymph node chain[J].Endocrinol Nutr,2014,61(3):e11-e12.DOI:10.1016/j.endonu.2013.10.005.
10 王勤学.儿童甲状舌管囊肿的诊断及治疗[J].山西医药杂志,2018,47(7):777-778.DOI:10.3969/j.issn.0253-9926.2018.07.016. Wang QX.Diagnosis and Treatment of Thyroglossal Tongue Cyst in Children[J].Shanxi Medical Journal,2018,47 (7):777-778.DOI:10.3969/j.issn.0253-9926.2018.07.016.
11 徐小方,于开涛,葛成,等.甲状舌管乳头状癌1例及文献复习[J].口腔颌面外科杂志,2014,24(6):475-478.DOI:10.3969/j.issn.1005-4979.2014.06.27. Xu XF,Yu KT,Ge C,et al.Thyroid Papillary Carcinoma Arising in Thyroglossal Duct Cyst:Case Report and Review of Literature[J].Journal of Oral and Maxillofacial Surgery,2014,24 (6):475-478.DOI:10.3969/j.issn.1005-4979.2014.06.27.
12 Chu YC,Han JY,Han HS,et al.Primary papillary carcinoma arising in a thyroglossal duct cyst[J].Yonsei Med J,1997,163(2):143.DOI:10.3349/ymj.2002.43.3.381.
13 Gaddikeri S,Chapman PR.Radiology quiz case 2:papillary carcinoma in a thyroglossal duct cyst (TGDC)[J].JAMA Otolaryngol Head Neck Surg,2013,139(1):95-96.DOI:10.1001/jamaoto.2013.1159a.
14 Yang YJ,Haghir S,Wanamaker JR,et al.Diagnosis of papillary carcinoma in a thyroglossal duct cyst by fine-needle aspiration biopsy[J].Arch Pathol Lab Med,2000,124(1):139-142.DOI:10.1043/0003-9985(2000)124<0139:DOPCIA>2.0.CO;2.
15 Diaconescu MR,Costea I,Glod M,et al.Thyroglossal Duct Cyst Carcinoma in Child and Adult.Two Case Reports[J].Chirurgia (Bucur),2015,110(6):550-553.
16 Pfeiffer MS,Kim GH,Krishnan M.Thyroglossal duct papillary carcinoma in a 15-year old female and review of pediatric cases of thyroglossal duct carcinoma[J].Int J Pediatr Otorhinolaryngol,2014,78(1):135-138.DOI:10.1016/j.ijporl.2013.10.013.
Memo
收稿日期:2018-11-08。
基金项目:国家自然科学青年基金（编号：81500395）
通讯作者:冯杰雄,Email:fengjiexiong@126.com