Zhao Hongmei,Zhan Meizheng,Li Yong,et al.Value of multidisciplinary cooperation in therapy refractory digestive tract polyps in children[J].Journal of Clinical Pediatric Surgery,,19():326-330.[doi:10.3969/j.issn.1671-6353.2020.04.009]
Value of multidisciplinary cooperation in therapy refractory digestive tract polyps in children
- Keywords:
- Intestinal Polyps; Laparoscopy; Multidisciplinary Cooperation; Child
- CLC:
- R726.1;R574
- Abstract:
- Objective To explore the clinical value and safety of multi-disciplinary cooperating laparoscopic assisted enteroscopic polypectomy for pediatric refractory digestive tract polyps. Methods Retrospective analysis was performed for clinical data of 21 children of pediatric refractory deep digestive tract polyps undergoing laparoscopically assisted enteroscopic polypectomy from 2008 to 2018. Results There were 14 boys and 7 girls with an average age of (7±2.1) years.The causes were Peutz-Jeghers syndrome (n=15),familial ademomatous polyposis (n=1) and intestinal polyps (n=5).And the pathological diagnoses were hamartoma (n=8),juvenile polyps (n=9),adenomatous polyps (n=1) and hyperplastic polyps (n=3).Clinical manifestations included recurrent intussusception (n=16) and incomplete intestinal obstruction (n=5).And all children underwent laparoscopic-assisted enteroscopic polypectomy,including duodenal horizontal segment polypectomy (n=2) and upper colon polypectomy (n=3).The remainder underwent small intestine polypectomy.A total of 143 polyps were removed and submitted for pathological examinations.The maximal diameter of polyp was 5×4.5 cm.One patient with broad-based giant polyp (5.5×5 cm) that could not be removed endoscopically was finally operated.Three cases of giant polyps were sutured with titanium clip while 5 cases of polyps were treated with titanium clip for hemostasis.Two cases finally underwent laparoscopic repair because of intestinal perforation intraoperatively. Conclusion Under the guidance of abdominal CT and ultrasound,laparoscopic assisted enteroscopic polypectomy has fewer complications and more safety so that more satisfactory clinical outcomes may be achieved.Only few cases require surgery.Therefore it is worthy of promoting multidisciplinary cooperation plus mini-invasive treatment.
References:
1 赵晓军,李娜,王昕,等.气囊辅助小肠镜治疗Peutz-Jeghers综合征的临床价值[J].胃肠病学和肝病学杂志,2015,24(5):525-526.DOI:10.3969 j.Issn.1006-5709.2015.05.010. Zhao XJ,Li N,Wang X,et al.Clinical value of balloon assisted enteroscopy for patients with Peutz-Jeghers syndrome[J].Chin J Gastroenterol Hepatol,2015,24(5):525-526.DOI:10.3969 j.Issn.1006-5709.2015.05.010.
2 Ngamruengphong S,Pohl H,Haito-Chavez Y,et al.Update on Difficult Polypectomy Techniques[J].Curr Gastroenterol Rep,2016,18(1):3.DOI:10.1007/s11894-015-0476-7.
3 Daniell J,Plazzer JP,Perera A,et al.An exploration of genotype-phenotype link between Peutz-Jeghers syndrome and STK11:a review[J].Fam Cancer,2018,17(3):421-427.DOI:10.1007/s10689-017-0037-3.
4 Lim SH,Levenick JM,Mathew A,et al.Endoscopic management of large (≥ 2 cm) non-pedunculated colorectal polyps:impact of polyp morphology on outcomes[J].Dig Dis Sci,2016,61(12):3572-3583.DOI:10.1007/s10620-016-4314-z.
5 Castro R,Pimentel-Nunes P,Dinis-Ribeiro M.Evaluation and management of Gastric epithelial polyps[J].Best Pract Res Clin Gastroenterol,2017,31(4):381-387.DOI:10.1016/j.bpg.2017.06.001.
6 颜禄斌,李斌德,李来元,等.黑斑息肉综合征及其并发症2例报告并文献复习[J].临床小儿外科杂志,2013,12(5):427-429.DOI:10.3969/j.issn.1671-6353.2013.05.025. Yan LB,Li BD,Li LY,et al.Peutz-Jeghers syndrome and its complications and literature review:a report of two cases[J].J Clin Pediatr Surg,2013,12(5):427-429.DOI:10.3969/j.issn.1671-6353.2013.05.025.
7 Zhang M,Shin EJ.Successful endoscopic strategies for difficult polypectomy[J].Curr Opin Gastroenterol,2013,29(5):489-894.DOI:10.1097/MOG.0b013e3283646e89.
8 Shaco-Levy R,Jasperson KW,Martin K,et al.Morphologic characterization of hamartomatous gastrointestinal polyps in Cowden syndrome,Peutz-Jeghers syndrome,and juvenile polyposis syndrome[J].Hum Pathol,2016,49:39-48.DOI:10.1016/j.humpath.2015.10.002.
9 苗莉莉,刘小芳,张新村,等.高频超声对儿童Peutz-Jeghers综合征的诊断价值[J].中华超声影像学杂志,2016,25(5):445-447.DOI:10.3760/cma.j.issn.1004-4477.2016.05.022. Miao LL,Liu XF,Zhang XC,et al.Diagnostic value of high frequency ultrasound in children with Peutz-Jeghers syndrome[J].Chin J Ultrasonogr,2016,25(5):445-447.DOI:10.3760/cma.j.issn.1004-4477.2016.05.022
10 方金晶.超声诊断小儿肠息肉继发性肠套叠的临床价值[J].影像研究与医学应用,2019,3(7):197-198.DOI:10.3969/j.issn.2096-3807.2019.07.139. Fang JJ.Clinical value of ultrasound in the diagnosis of secondary intussusception in children with intestinal polyps[J].Journal of Imaging Research and Medical Applications,2019,3(7):197-198.DOI:10.3969/j.issn.2096-3807.2019.07.139.
11 陈燚,宋云龙,王萍,等.小肠充气螺旋CT三维重建技术对Peutz-Jeghers综合征诊断价值探讨[J].中国CT和MRI杂志,2018,16(2):31-34.DOI:10.3969/j.issn.1672-5131.2018.02.010. Chen Y,Song YL,Wang P,et al.Study on the value of small bowel inflation by transanal insufflation in the diagnosis of Peutz-Jeghers Syndrome[J].Chinese Journal of CT and MRI,2018,16(2):31-34.DOI:10.3969/j.issn.1672-5131.2018.02.010.
12 Li Z,Sun M,Song B,et al.Gastrointestinal hemorrhage caused by adult intussusception secondary to small intestinal tumors:Two case reports[J].Medicine (Baltimore),2018,97(34):e12053.DOI:10.1097/MD.0000000000012053.
13 Blanco-Velasco G,Hernández-Mondragón OV,Blancas-Valencia JM,et al.Safety and efficacy of small bowel polypectomy using a balloon-assisted enteroscope in pediatric patients with Peutz-Jeghers syndrome[J].Rev Gastroenterol Mex,2018,83(3):234-237.DOI:10.1016/j.rgmx.2017.07.003.
14 Tomas C,Soyer P,Dohan A,et al.Update on imaging of Peutz-Jeghers syndrome[J].World J Gastroenterol,2014,20(31):10864-10875.DOI:10.3748/wjg.v20.i31.10864.
15 Latchford A,Cohen S,Auth M,et al.Management of Peutz-Jeghers syndrome in children and adolescents:a position paper from the ESPGHAN Polyposis Working Group[J].J Pediatr Gastroenterol Nutr,2019,68(3):442-452.DOI:10.1097/MPG.0000000000002248.
16 Syngal S,Brand RE,Church JM,et al.ACG clinical guideline:Genetic testing and management of hereditary gastrointestinal cancer syndromes[J].Am J Gastroenterol,2015,110(2):223-263.DOI:10.1038/ajg.2014.435.
17 Jiang YL,Zhao ZY,Li BR,et al.Early screening the small bowel is key to protect Peutz-Jeghers syndrome patients from surgery:a novel mutation c.243delG in STK11 gene[J].BMC Gastroenterol,2019,19(1):70.DOI:10.1186/s12876-019-0987-z.
Memo
收稿日期:2019-06-16。
基金项目:湖南省自然科学基金面上项目(编号:2019JJ40155)
通讯作者:游洁玉,Email:yjy660111@sina.com