Xing Xiaoyu,Chen Siping,Zhong Liang,et al.A preliminary study on the relationship between vitamin D and its receptor and ureteropelvic junction obstruction[J].Journal of Clinical Pediatric Surgery,,19():209-212.[doi:10.3969/j.issn.1671-6353.2020.03.004]
A preliminary study on the relationship between vitamin D and its receptor and ureteropelvic junction obstruction
- Keywords:
- Vitamin D; Ureteropelvic Junction Obstruction; Fibrosis
- CLC:
- R726.9;R692.7;R977.2+4
- Abstract:
- Objective To explore the correlation between UPJO and vitamin D and its receptor.Methods 10 cases of children who underwent UPJO disconnection pyeloplasty were divided into UPJO group.8 children who underwent renal and ureterectomy for renal tumors were enrolled in the control group.The preoperative contents of 25 hydroxyvitamin D2,25 hydroxyvitamin D3 and total 25 hydroxyvitamin D were detected.VDR,TGF-β and cadherin E content were detected by ELISA staining.The results of the test were used t test for statistical analysis,compare the differences between two groups,and analyze the correlation between vitamin D and its receptor and UPJO.Results there was no significant difference between the two groups in the detection of vitamin D three items before operation.The mean values of VDR,TGF-β and cadherin E in UPJO group were 771.6±70.57 ng/g,131.0±10.33 ng/g and 125.5±10.98 ng/g respectively.The corresponding mean values in tumor control group were 2128±251.8,82.3±6.834 and 386.6±78.71 ng/g respectively.The data of two groups were tested by t-test (P<0.05).The expression of VDR and cadherin E in UPJO group was significantly lower than that in control group.TGF-β was significantly higher than that of the control group.Conclusion The expression of VDR receptor in UPJO group was significantly lower than that in control group,suggesting that VDR may be related to UPJO.The initial mechanism may be the decrease in the expression of VDR at UPJ,causing a significant increase in the expression of TGF-β,which aggravates the tissue fibrosis at the UPJ,resulting in or aggravating UPJO.
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Memo
收稿日期:2018-05-22。
基金项目:国家自然科学基金（编号：81871149），国家自然科学基金（编号：81601267）
通讯作者:孙杰,Email:sunjie@scmc.com.cn